Search Results - "Guimaraes, Vanessa R"
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MicroRNA-23b and microRNA-27b plus flutamide treatment enhances apoptosis rate and decreases CCNG1 expression in a castration-resistant prostate cancer cell line
Published in Tumor biology (01-11-2018)“…The acquisition of a castration-resistant prostate cancer phenotype by prostate cancer cells is the alteration that has the worst prognosis for patients. The…”
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The Effect of Gene Editing by CRISPR-Cas9 of miR-21 and the Indirect Target MMP9 in Metastatic Prostate Cancer
Published in International journal of molecular sciences (01-10-2023)“…Prostate cancer (PCa) has a high prevalence and represents an important health problem, with an increased risk of metastasis. With the advance of CRISPR-Cas9…”
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Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer
Published in International journal of molecular sciences (01-06-2023)“…MicroRNAs (miRNAs) have gained a prominent role as biomarkers in prostate cancer (PCa). Our study aimed to evaluate the potential suppressive effect of miR-137…”
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Upregulation of shelterin and CST genes and longer telomeres are associated with unfavorable prognostic characteristics in prostate cancer
Published in Cancer genetics (01-06-2024)“…•Comprehensive analysis of prostate cancer samples and cell lines to explore telomeres and associated genes as prognostic biomarkers.•Despite few genetic…”
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Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology
Published in Cancer genetics (01-04-2022)“…•First pan-cancer analysis of the telomeric CTC1-STN1-TEN1 complex.•Somatic landscape and gene expression pattern of CTC1, STN1, and TEN1 in over 10,000…”
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Cholesterol Triggers Nuclear Co-Association of Androgen Receptor, p160 Steroid Coactivators, and p300/CBP-Associated Factor Leading to Androgenic Axis Transactivation in Castration-Resistant Prostate Cancer
Published in Cellular physiology and biochemistry (02-12-2022)“…BACKGROUND/AIMS: Cholesterol modulates intratumoral androgenic signaling in prostate cancer; however, the molecular mechanisms underlying these changes in…”
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Overexpression of miR-17-5p may negatively impact p300/CBP factor-associated inflammation in a hypercholesterolemic advanced prostate cancer model
Published in Molecular biology reports (01-09-2023)“…Background Previously, we demonstrated that cholesterol triggers the increase in p300/CBP-associated factor (PCAF), targeted by miR-17-5p. The p300, IL-6,…”
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Shorter leukocyte telomere length is associated with severity of COVID-19 infection
Published in Biochemistry and biophysics reports (01-09-2021)“…The infection by COVID-19 is a serious global public health problem. An efficient way to improve this disease's clinical management would be to characterize…”
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MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19
Published in Molecular biology research communications (01-09-2021)“…COVID-19 represents a public health emergency, whose mechanism of which is not fully understood. It is speculated that microRNAs may play a crucial role in…”
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MicroRNA-29b attenuates fibrosis in a rat model of Peyronie's disease
Published in Andrology (Oxford) (24-06-2024)“…Peyronie's disease is characterized by the formation of fibrotic plaques in the penile tunica albuginea. Effective treatments are limited, warranting the…”
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Can increased expression of miR-Let-7c reduce the transition potential of high-grade urothelial carcinoma?
Published in Molecular biology reports (01-12-2021)“…Background Bladder cancer is the leading transitional cell carcinoma affecting men and women with high morbidity and mortality rates, justifying the need to…”
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Combined spinal and general anesthesia attenuate tumor promoting effects of surgery. An experimental animal study
Published in Annals of medicine and surgery (01-03-2022)“…Radical prostatectomy, a standard management approach for localized Prostate Cancer (PC), may cause a stress response associated with immune modulating…”
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Robotically assisted laparoscopic radical prostatectomy induces lower tissue trauma than radical retropubic prostatectomy
Published in Journal of robotic surgery (01-02-2021)“…To compare tissue trauma between Retropubic Radical Prostatectomy and Robotically Assisted Laparoscopic Radical Prostatectomy by inflammatory mediators. Serum…”
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Can we use Ki67 expression to predict prostate cancer aggressiveness?
Published in Revista do Colégio Brasileiro de Cirurgiões (2022)“…ABSTRACT Introduction: specialists have an urge for biomarkers that can discriminate indolent prostate cancer from aggressive tumors. Ki67 is a proliferation…”
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Phospholipase A2 expression in prostate cancer as a biomarker of good prognosis: A comprehensive study in patients with long follow-up
Published in Urologia (01-11-2024)“…Background: Phospholipase A2 (PLA2) is a large family of enzymes involved in the inflammatory process that catalyzes the hydrolysis of membrane phospholipids,…”
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Podemos usar a expressão de Ki67 para prever a agressividade do câncer de próstata?
Published in Revista do Colégio Brasileiro de Cirurgiões (2022)“…RESUMO Introdução: especialistas precisam biomarcadores que podem discriminar o câncer de próstata indolente de tumores agressivos. Ki67 é um marcador de…”
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