Search Results - "Guimaraes, Francisco S."

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety‐related and substance abuse disorders by Lee, Jonathan L C, Bertoglio, Leandro J, Guimarães, Francisco S, Stevenson, Carl W

“…Learning to associate cues or contexts with potential threats or rewards is adaptive and enhances survival. Both aversive and appetitive memories are therefore…”
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The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling by Fogaça, Manoela V., Campos, Alline C., Coelho, Ludmila D., Duman, Ronald S., Guimarães, Francisco S.

“…Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, attenuate the anxiogenic effects induced…”
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Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age by Crippa, José A, Guimarães, Francisco S, Campos, Alline C, Zuardi, Antonio W

“…Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. The aim…”
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Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test by Linares, Ila M, Zuardi, Antonio W, Pereira, Luis C, Queiroz, Regina H, Mechoulam, Raphael, Guimarães, Francisco S, Crippa, José A

“…Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped…”
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The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system by Campos, Alline C., Ortega, Zaira, Palazuelos, Javier, Fogaça, Manoela V., Aguiar, Daniele C., Díaz-Alonso, Javier, Ortega-Gutiérrez, Silvia, Vázquez-Villa, Henar, Moreira, Fabricio A., Guzmán, Manuel, Galve-Roperh, Ismael, Guimarães, Francisco S.

“…Cannabidiol (CBD), the main non-psychotomimetic component of the plant Cannabis sativa, exerts therapeutically promising effects on human mental health such as…”
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On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment by STERN, Cristina Aj, GAZARINI, Lucas, TAKAHASHI, Reinaldo N, GUIMARAES, Francisco S, BERTOGLIO, Leandro J

“…The search for reconsolidation blockers may uncover clinically relevant drugs for disrupting memories of significant stressful life experiences, such as those…”
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Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex by Sales, Amanda J., Fogaça, Manoela V., Sartim, Ariandra G., Pereira, Vitor S., Wegener, Gregers, Guimarães, Francisco S., Joca, Sâmia R. L.

“…Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that…”
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Animal models of anxiety disorders and stress by Campos, Alline C, Fogaça, Manoela V, Aguiar, Daniele C, Guimarães, Francisco S

“…Anxiety and stress-related disorders are severe psychiatric conditions that affect performance in daily tasks and represent a high cost to public health. The…”
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Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors by Sales, Amanda J, Biojone, Caroline, Terceti, Mateus S, Guimarães, Francisco S, Gomes, Marcus VM, Joca, Sâmia RL

“…BACKGROUND AND PURPOSE Epigenetic modifications are thought to play an important role in the neurobiology of depression. Antidepressant treatment induces…”
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Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders by Campos, Alline C, Fogaça, Manoela V, Scarante, Franciele F, Joca, Sâmia R L, Sales, Amanda J, Gomes, Felipe V, Sonego, Andreza B, Rodrigues, Naielly S, Galve-Roperh, Ismael, Guimarães, Francisco S

“…Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The…”
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Cannabidiol prevents haloperidol-induced vacuos chewing movements and inflammatory changes in mice via PPARγ receptors by Sonego, Andreza B., Prado, Douglas S., Vale, Gabriel T., Sepulveda-Diaz, Julia E., Cunha, Thiago M., Tirapelli, Carlos R., Del Bel, Elaine A., Raisman-Vozari, Rita, Guimarães, Francisco S.

“…•CBD prevented haloperidol-induced orofacial dyskinesia and inflammatory changes.•CBD reduced microglial activation and oxidative stress stimulated by LPS in…”
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"NO" Time in Fear Response: Possible Implication of Nitric-Oxide-Related Mechanisms in PTSD by Fronza, Mariana G, Ferreira, Bruna F, Pavan-Silva, Isabela, Guimarães, Francisco S, Lisboa, Sabrina F

“…Post-traumatic stress disorder (PTSD) is a psychiatric condition characterized by persistent fear responses and altered neurotransmitter functioning due to…”
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Cannabidiol disrupts the consolidation of specific and generalized fear memories via dorsal hippocampus CB1 and CB2 receptors by Stern, Cristina A.J., da Silva, Thiago R., Raymundi, Ana M., de Souza, Camila P., Hiroaki-Sato, Vinicius A., Kato, Luiza, Guimarães, Francisco S., Andreatini, Roberto, Takahashi, Reinaldo N., Bertoglio, Leandro J.

“…Pharmacological interventions able to modulate a fear memory while it is consolidated could have therapeutic value in tempering those maladaptively…”
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Serious adverse effects of cannabidiol (CBD): a review of randomized controlled trials by Dos Santos, Rafael G, Guimarães, Francisco S, Crippa, José Alexandre S, Hallak, Jaime E C, Rossi, Giordano Novak, Rocha, Juliana Mendes, Zuardi, Antônio W

“…Recent trials using cannabidiol (CBD) have shown that most acute and prolonged adverse effects of CBD are mild to moderate, with rare serious adverse effects…”
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A time‐dependent contribution of hippocampal CB1, CB2 and PPARγ receptors to cannabidiol‐induced disruption of fear memory consolidation by Raymundi, Ana Maria, Silva, Thiago R., Zampronio, Aleksander R., Guimarães, Francisco S., Bertoglio, Leandro J., Stern, Cristina A.J.

“…Background and Purpose In preclinical studies, cannabidiol (CBD) mitigates fear memories by facilitating their extinction or interfering with their…”
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Chronic cannabidiol exposure promotes functional impairment in sexual behavior and fertility of male mice by Carvalho, Renata K., Souza, Maingredy R., Santos, Monaliza L., Guimarães, Francisco S., Pobbe, Roger Luís H., Andersen, Monica L., Mazaro-Costa, Renata

“…•CBD has biphasic effects on male copulation.•CBD negatively affected the fertilization rate and the number of litters.•The antifertility properties indicate…”
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Cannabidiol attenuates prepulse inhibition disruption by facilitating TRPV1 and 5-HT1A receptor-mediated neurotransmission by Pedrazzi, João F.C., Silva-Amaral, Danyelle, Issy, Ana C., Gomes, Felipe V., Crippa, José A., Guimarães, Francisco S., Del Bel, Elaine

“…Individuals with schizophrenia (SCZ) often present sensorimotor gating impairments that can be investigated by the prepulse inhibition test (PPI). PPI…”
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Hemopressin as a breakthrough for the cannabinoid field by Heimann, Andrea S., Dale, Camila S., Guimarães, Francisco S., Reis, Ricardo A.M., Navon, Ami, Shmuelov, Michal A., Rioli, Vanessa, Gomes, Ivone, Devi, Lakshmi L., Ferro, Emer S.

“…Hemopressin (PVNFKFLSH in rats, and PVNFKLLSH in humans and mice), a fragment derived from the α-chain of hemoglobin, was the first peptide described to have…”
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Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders by Jurkus, Regimantas, Day, Harriet L L, Guimarães, Francisco S, Lee, Jonathan L C, Bertoglio, Leandro J, Stevenson, Carl W

“…Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are…”
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Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice by Gomes, Felipe V., Del Bel, Elaine A., Guimarães, Francisco S.

“…Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa plant that produces antipsychotic effects in rodents and humans. It also reverses…”
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