Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon

To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October...

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Published in:	Revista panamericana de salud pública Vol. 44; no. 116; pp. e116 - 5
Main Authors:	de Oliveira, Consuelo S, de Matos, Haroldo José, Ramos, Francisco Luzio de Paula, Pinto, Ana Yece das N, Graim, Priscila Nathyelly Dos S, Guimarães, Vivianne de Paula R, Gomes, Luna Thaís S, Serra, Emilene M F, Cruz, Ana Cecília, Leal, Alessandra, Henriques, Daniele F, Lima, Juliana A, Anjos, Maura V, Pinto, Eliana V, de Souza, Alana W, Vasconcelos, Pedro Fernando da C
Format:	Journal Article
Language:	English
Published:	United States Organización Panamericana de la Salud 2020 Pan American Health Organization
Subjects:	brazil infectious microcephaly Original Research pregnancy complications zika virus infection microcephaly Brazil infectious pregnancy complications Zika virus infection
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Summary:	To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October 2015 to December 2017. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1020-4989 1680-5348
DOI:	10.26633/RPSP.2020.116