Search Results - "Guillermo Labadié"

1,2,3-Triazoles in Biomolecular Crystallography: A Geometrical Data-Mining Approach by Carlucci, Renzo, Lisa, María-Natalia, Labadie, Guillermo R.

“…The 1,2,3-triazole scaffold has become very attractive to identify new chemical entities in drug discovery projects. Despite the widespread use of click…”
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Editorial: Combatting tropical diseases: a multi-level approach by Sasidharan, Santanu, Labadie, Guillermo R

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Understanding the Fate of the Banert Cascade of Propargylic Azides: Sigmatropic versus Prototropic Pathway by Villarreal-Parra, Miguel, Di Gresia, Gabriel E., Labadie, Guillermo R., Vallejos, Margarita M.

“…The Banert cascade is an efficient synthetic strategy for obtaining 4,5-disubstituted 1,2,3-triazoles. The reaction can proceed via a sigmatropic or…”
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Identification of a Bifunctional Maize C- and O-Glucosyltransferase by Falcone Ferreyra, María Lorena, Rodriguez, Eduardo, Casas, María Isabel, Labadie, Guillermo, Grotewold, Erich, Casati, Paula

“…Flavonoids accumulate in plant vacuoles usually as O-glycosylated derivatives, but several species can also synthesize flavonoid C-glycosides. Recently, we…”
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Insight into the factors controlling the equilibrium of allylic azides by Vallejos, Margarita M, Labadie, Guillermo R

“…Several allylic azides with different double bond substitutions were studied to understand the factors, governing their equilibrium using density functional…”
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New one-pot synthesis of anti-tuberculosis compounds inspired on isoniazid by Ghiano, Diego G., Recio-Balsells, Alejandro, Bortolotti, Ana, Defelipe, Lucas A., Turjanski, Adrián, Morbidoni, Héctor R., Labadie, Guillermo R.

“…A library of thirty N-substituted tosyl N’-acryl-hydrazones was prepared with p-toluenesulfonyl hydrazide, methyl propiolate and different aldehydes in a…”
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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids by Benítez, Diego, Medeiros, Andrea, Fiestas, Lucía, Panozzo-Zenere, Esteban A, Maiwald, Franziska, Prousis, Kyriakos C, Roussaki, Marina, Calogeropoulou, Theodora, Detsi, Anastasia, Jaeger, Timo, Šarlauskas, Jonas, Peterlin Mašič, Lucíja, Kunick, Conrad, Labadie, Guillermo R, Flohé, Leopold, Comini, Marcelo A

“…The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as…”
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Systematic study of 1,2,3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases by Porta, Exequiel O.J., Ballari, María Sol, Carlucci, Renzo, Wilkinson, Shane, Ma, Guoyi, Tekwani, Babu L., Labadie, Guillermo R.

“…A series of thirty 1,2,3-triazolylsterols, inspired by azasterols with proven antiparasitic activity, were prepared by a stereocontrolled synthesis. Ten of…”
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Expanding the scope of novel 1,2,3-triazole derivatives as new antiparasitic drug candidates by Carlucci, Renzo, Di Gresia, Gabriel, Mediavilla, María Gabriela, Cricco, Julia A, Tekwani, Babu L, Khan, Shabana I, Labadie, Guillermo R

“…We have previously shown that prenyl and aliphatic triazoles are interesting motifs to prepare new chemical entities for antiparasitic and antituberculosis…”
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Computational approaches for drug discovery against trypanosomatid-caused diseases by Pereira, Claudio A, Sayé, Melisa, Reigada, Chantal, Silber, Ariel M, Labadie, Guillermo R, Miranda, Mariana R, Valera-Vera, Edward

“…During three decades, only about 20 new drugs have been developed for malaria, tuberculosis and all neglected tropical diseases (NTDs). This critical situation…”
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Lipophilic modification of salirasib modulates the antiproliferative and antimigratory activity by Ballari, María Sol, O. J. Porta, Exequiel, Zalazar, Evelyn Arel, Etichetti, Carla M. Borini, Padrón, José M., Girardini, Javier E., Labadie, Guillermo R.

“…[Display omitted] Salirasib, or farnesylthiosalicylic acid (FTS), is a salicylic acid derivative with demonstrated antineoplastic activity. While designed as a…”
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Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase by Sabatini, Martin, Comba, Santiago, Altabe, Silvia, Recio‐Balsells, Alejandro I., Labadie, Guillermo R., Takano, Eriko, Gramajo, Hugo, Arabolaza, Ana

“…Iterative type I polyketide synthases (PKS) are megaenzymes essential to the biosynthesis of an enormously diverse array of bioactive natural products. Each…”
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Antifungal activity and cytotoxicity of extracts and triterpenoid saponins obtained from the aerial parts of Anagallis arvensis L by Soberón, José R., Sgariglia, Melina A., Pastoriza, Ana C., Soruco, Estela M., Jäger, Sebastián N., Labadie, Guillermo R., Sampietro, Diego A., Vattuone, Marta A.

“…Anagallis arvensis L. (Primulaceae) is used in argentinean northwestern traditional medicine to treat fungal infections. We are reporting the isolation and…”
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Expanding the scope of synthetic 1,2,4-trioxanes towards Trypanosoma cruzi and Leishmania donovani by Medrán, Noelia S., Sayé, Melisa, Pereira, Claudio A., Tekwani, Babu L., La-Venia, Agustina, Labadie, Guillermo R.

“…[Display omitted] A series of synthetic 1,2,4-trioxanes related to artemisinin was tested against L. donovani and T. cruzi parasites. This screening identified…”
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Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves by Galles, Celina, Prez, Gastón M., Penkov, Sider, Boland, Sebastian, Porta, Exequiel O. J., Altabe, Silvia G., Labadie, Guillermo R., Schmidt, Ulrike, Knölker, Hans-Joachim, Kurzchalia, Teymuras V., de Mendoza, Diego

“…Proper cholesterol transport is crucial for the functionality of cells. In C . elegans , certain cholesterol derivatives called dafachronic acids (DAs) govern…”
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Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives by Ghiano, Diego G., de la Iglesia, Agustina, Liu, Nina, Tonge, Peter J., Morbidoni, Héctor R., Labadie, Guillermo R.

“…A collection of 1,2,3-triazoles unsaturated fatty acid mimics were efficiently synthesized by click chemistry. The 1,4-disubstituted analogs prepared covered…”
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Repurposing antiparasitic N,N′‐aliphatic diamine derivatives as promising antimycobacterial agents by Recio‐Balsells, Alejandro I., Carlucci, Renzo, Giovannuzzi, Simone, Carta, Fabrizio, Supuran, Claudiu T., Tekwani, Babu L., Morbidoni, Héctor R., Labadie, Guillermo R.

“…In previous studies, we demonstrated the potent activity of a library of 25 N,N′‐disubstituted diamines (NNDDA) toward Trypanosomatid and Apicomplexa…”
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Evaluation of proline analogs as trypanocidal agents through the inhibition of a Trypanosoma cruzi proline transporter by Sayé, Melisa, Fargnoli, Lucía, Reigada, Chantal, Labadie, Guillermo R., Pereira, Claudio A.

“…Trypanosoma cruzi, the etiological agent of Chagas disease, uses proline as its main carbon source, essential for parasite growth and stage differentiation in…”
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Synthesis and interaction of terminal unsaturated chemical probes with Mycobacterium tuberculosis CYP124A1 by Díaz-Storani, Luz, Clary, Anaelle A., Moreno, Diego M., Ballari, María Sol, Porta, Exequiel O.J., Bracca, Andrea B.J., Johnston, Jonathan B., Labadie, Guillermo R.

“…[Display omitted] A series of C15–C20 isoprenyl derivatives bearing terminal alkenyl and alkynyl groups were synthesized as possible substrates of the…”
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Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents by Fernández de Luco, Julia, Recio-Balsells, Alejandro I, Ghiano, Diego G, Bortolotti, Ana, Belardinelli, Juán Manuel, Liu, Nina, Hoffmann, Pascal, Lherbet, Christian, Tonge, Peter J, Tekwani, Babu, Morbidoni, Héctor R, Labadie, Guillermo R

“…Triclosan and isoniazid are known antitubercular compounds that have proven to be also active against Leishmania parasites. On these grounds, a collection of…”
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