Search Results - "Guillén, Gerardo"

Nanopore Translocation Reveals Electrophoretic Force on Noncanonical RNA:DNA Double Helix by Bošković, Filip, Maffeo, Christopher, Patiño-Guillén, Gerardo, Tivony, Ran, Aksimentiev, Aleksei, Keyser, Ulrich F.

“…Electrophoretic transport plays a pivotal role in advancing sensing technologies. So far, systematic studies have focused on the translocation of canonical…”
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Single-molecule RNA sizing enables quantitative analysis of alternative transcription termination by Patiño-Guillén, Gerardo, Pešović, Jovan, Panić, Marko, Savić-Pavićević, Dušanka, Bošković, Filip, Keyser, Ulrich Felix

“…Transcription, a critical process in molecular biology, has found many applications in RNA synthesis, including mRNA vaccines and RNA therapeutics. However,…”
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Can Complementary Prime-Boost Immunization Strategies Be an Alternative and Promising Vaccine Approach Against Dengue Virus? by Valdés, Iris, Lazo, Laura, Hermida, Lisset, Guillén, Gerardo, Gil, Lázaro

“…Dengue is one of the most important diseases transmitted by mosquitoes. Dengvaxia®, a vaccine registered in several countries, cannot be administered to…”
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Type I interferon signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccines by Züst, Roland, Toh, Ying-Xiu, Valdés, Iris, Cerny, Daniela, Heinrich, Julia, Hermida, Lisset, Marcos, Ernesto, Guillén, Gerardo, Kalinke, Ulrich, Shi, Pei-Yong, Fink, Katja

“…Dengue virus (DENV) infects an estimated 400 million people every year, causing prolonged morbidity and sometimes mortality. Development of an effective…”
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A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice by Lazo, Laura, Bequet-Romero, Monica, Lemos, Gilda, Musacchio, Alexis, Cabrales, Ania, Bruno, Andy J., Ariel Espinosa, Luis, Saloheimo, Markku, Vitikainen, Marika, Hernández, Amalia, Emalfarb, Mark, Tchelet, Ronen, Suzarte, Edith, Guillén, Gerardo

“…Since the beginning of the COVID-19 pandemic, the development of effective vaccines against this pathogen has been a priority for the scientific community…”
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Recombinant protein based on domain III and capsid regions of zika virus induces humoral and cellular immune response in immunocompetent BALB/c mice by Valdes, Iris, Gil, Lázaro, Lazo, Laura, Cobas, Karem, Romero, Yaremis, Bruno, Andy, Suzarte, Edith, Pérez, Yusleidi, Cabrales, Ania, Ramos, Yassel, Hermida, Lisset, Guillén, Gerardo

“…Zika virus infection continues to be a global concern for human health due to the high-risk association of the disease with neurological disorders and…”
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Aiming at the heart: the capsid protein of dengue virus as a vaccine candidate by Laura Lazo, Iris Valdes, Gerardo Guillén, Lisset Hermida, Lázaro Gil

“…Introduction: Dengue fever remains as a health problem worldwide. Although Dengvaxia®, was registered in several countries, the results after the immunization…”
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Addition of nucleotide adjuvants enhances the immunogenicity of a recombinant subunit vaccine against the Zika virus in BALB/c mice by Valdes, Iris, Suzarte, Edith, Lazo, Laura, Cobas, Karem, Cabrales, Ania, Pérez, Yusleidi, Garateix, Rocío, Silva, José A., Aguilar, Julio C., Guzman, Carlos A., Guillén, Gerardo

“…Zika virus (ZIKV) infection remains a global public health problem. After the “Public Health Emergencies of International Concern” declared in February 2016,…”
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Broad humoral immunity generated in mice by a formulation composed of two antigens from the Delta variant of SARS-CoV-2 by Lobaina, Yadira, Chen, Rong, Suzarte, Edith, Ai, Panchao, Huerta, Vivian, Tan, Changyuan, Alvarez-Lajonchere, Liz, Liling, Yang, Musacchio, Alexis, Silva, Ricardo, Guillén, Gerardo, Zaixue, Jiang, Yang, Ke, Perera, Yasser, Hermida, Lisset

“…Due to the rapid development of new variants of SARS-CoV-2 as well as the real threat of new coronavirus zoonosis events, the development of a preventive…”
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Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review by Berlanga-Acosta, Jorge, Guillén-Nieto, Gerardo, Rodríguez-Rodríguez, Nadia, Bringas-Vega, Maria Luisa, García-Del-Barco-Herrera, Diana, Berlanga-Saez, Jorge O, García-Ojalvo, Ariana, Valdés-Sosa, Mitchell Joseph, Valdés-Sosa, Pedro A

“…Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus countering apoptosis, beta-amyloid toxicity, and oxidative…”
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Domain III of the envelope protein as a dengue vaccine target by Guzman, Maria G, Hermida, Lisset, Bernardo, Lidice, Ramirez, Rosa, Guillén, Gerardo

“…A dengue vaccine should induce long-lasting, simultaneous protection to the four dengue viruses while avoiding the immune enhancement of viral infection…”
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The Nucleocapsid Protein of SARS-CoV-2, Combined with ODN-39M, Is a Potential Component for an Intranasal Bivalent Vaccine with Broader Functionality by Lobaina, Yadira, Chen, Rong, Suzarte, Edith, Ai, Panchao, Huerta, Vivian, Musacchio, Alexis, Silva, Ricardo, Tan, Changyuan, Martín, Alejandro, Lazo, Laura, Guillén-Nieto, Gerardo, Yang, Ke, Perera, Yasser, Hermida, Lisset

“…Despite the rapid development of vaccines against COVID-19, they have important limitations, such as safety issues, the scope of their efficacy, and the…”
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Preparing for the Next Pandemic: Increased Expression of Interferon-Stimulated Genes After Local Administration of Nasalferon or HeberNasvac by Aguiar Santiago, Jorge Agustín, Marrero Miragaya, Maria Acelia, Figueroa Oliva, Dariel Adrian, Aguilar Juanes, Andres, Idavoy Corona, Arletis, Martínez Fernández, Seknia, Morán Bertot, Ivis, Rodríguez Hernández, Meilyn, Canales López, Eduardo, Hernández Esteves, Ingrid, Silva Girado, José Angel, Estrada Vázquez, Regla Caridad, Gell Cuesta, Omar, Mendoza-Marí, Yssel, Valdés Prado, Iris, Rodríguez Ibarra, Chabeli, Palenzuela Gardon, Daniel Octavio, Pentón Arias, Eduardo, Guillén Nieto, Gerardo, Aguilar Rubido, Julio Cesar

“…HeberNasvac, a therapeutic vaccine for chronic hepatitis B, is able to safely stimulate multiple Toll-like receptors, increasing antigen presentation and in a…”
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Intralesional Infiltrations of Arteriosclerotic Tissue Cells-Free Filtrate Reproduce Vascular Pathology in Healthy Recipient Rats by Berlanga-Acosta, Jorge, Fernández-Mayola, Maday, Mendoza-Marí, Yssel, García-Ojalvo, Ariana, Martinez-Jimenez, Indira, Rodriguez-Rodriguez, Nadia, Playford, Raymond J, Reyes-Acosta, Osvaldo, Lopez-Marín, Laura, Guillén-Nieto, Gerardo

“…Lower-extremity arterial disease is a major health problem with increasing prevalence, often leading to non-traumatic amputation, disability and mortality. The…”
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A Tetravalent Formulation Based on Recombinant Nucleocapsid-like Particles from Dengue Viruses Induces a Functional Immune Response in Mice and Monkeys by Gil, Lázaro, Cobas, Karem, Lazo, Laura, Marcos, Ernesto, Hernández, Laura, Suzarte, Edith, Izquierdo, Alienys, Valdés, Iris, Blanco, Aracelys, Puentes, Pedro, Romero, Yaremis, Pérez, Yusleidi, Guzmán, María G, Guillén, Gerardo, Hermida, Lisset

“…Despite the considerable effort that has been invested in elucidating the mechanisms of protection and immunopathogenesis associated with dengue virus…”
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Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis by Marín-Prida, Javier, Pavón-Fuentes, Nancy, Lagumersindez-Denis, Nielsen, Camacho-Rodríguez, Hanlet, García-Soca, Ana Margarita, Sarduy-Chávez, Rocío de la Caridad, Vieira, Érica Leandro Marciano, Carvalho-Tavares, Juliana, Falcón-Cama, Viviana, Fernández-Massó, Julio Raúl, Hernández-González, Ignacio, Martínez-Donato, Gillian, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Cytokines, demyelination and neuroaxonal degeneration in the central nervous system are pivotal elements implicated in the pathogenesis of multiple sclerosis…”
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The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome by Marín-Prida, Javier, Rodríguez-Ulloa, Arielis, Besada, Vladimir, Llopiz-Arzuaga, Alexey, Batista, Nathália Vieira, Hernández-González, Ignacio, Pavón-Fuentes, Nancy, Marciano Vieira, Érica Leandro, Falcón-Cama, Viviana, Acosta, Emilio F., Martínez-Donato, Gillian, Cervantes-Llanos, Majel, Lingfeng, Dai, González, Luis J., Fernández-Massó, Julio Raúl, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Amaral, Flávio Almeida, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Introduction The antinociceptive and pharmacological activities of C-Phycocyanin (C-PC) and Phycocyanobilin (PCB) in the context of inflammatory arthritis…”
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Cuban Abdala vaccine: Effectiveness in preventing severe disease and death from COVID-19 in Havana, Cuba; A cohort study by Más-Bermejo, Pedro I., Dickinson-Meneses, Félix O., Almenares-Rodríguez, Kenia, Sánchez-Valdés, Lizet, Guinovart-Díaz, Raúl, Vidal-Ledo, María, Galbán-García, Enrique, Olivera-Nodarse, Yadira, Morgado-Vega, Isabel, Dueñas-Carrera, Santiago, Pujol, Merardo, Hernández-Bernal, Francisco, Limonta-Fernández, Miladys, Guillén-Nieto, Gerardo, Muzio-González, Verena L., Ayala-Ávila, Marta

“…COVID-19 vaccines have proven safe and efficacious in reducing severe illness and death. Cuban protein subunit vaccine Abdala has shown safety, tolerability…”
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Capsid protein: Evidences about the partial protective role of neutralizing antibody-independent immunity against dengue in monkeys by Gil, Lázaro, Izquierdo, Alienys, Lazo, Laura, Valdés, Iris, Ambala, Peris, Ochola, Lucy, Marcos, Ernesto, Suzarte, Edith, Kariuki, Thomas, Guzmán, Guadalupe, Guillén, Gerardo, Hermida, Lisset

“…Abstract The role of cellular immune response in dengue virus infection is not yet fully understood. Only few studies in murine models propose that CD8+…”
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A dose-response study in mice of a tetravalent vaccine candidate composed of domain III-capsid proteins from dengue viruses by Valdés, Iris, Marcos, Ernesto, Suzarte, Edith, Pérez, Yusleidi, Brown, Enma, Lazo, Laura, Cobas, Karem, Yaugel, Melyssa, Rodríguez, Yadira, Gil, Lázaro, Guillén, Gerardo, Hermida, Lisset

“…Tetra DIIIC is a subunit vaccine candidate based on domain III of the envelope protein and the capsid protein of the four serotypes of dengue virus. This…”
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