Search Results - "Guillaume, Jean‐Luc"

Understanding melatonin receptor pharmacology: Latest insights from mouse models, and their relevance to human disease by Tosini, Gianluca, Owino, Sharon, Guillaume, Jean-Luc, Jockers, Ralf

“…Melatonin, the neuro‐hormone synthesized during the night, has recently seen an unexpected extension of its functional implications toward type 2 diabetes…”
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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes by Bonnefond, Amélie, Clément, Nathalie, Fawcett, Katherine, Yengo, Loïc, Vaillant, Emmanuel, Guillaume, Jean-Luc, Dechaume, Aurélie, Payne, Felicity, Roussel, Ronan, Czernichow, Sébastien, Hercberg, Serge, Hadjadj, Samy, Balkau, Beverley, Marre, Michel, Lantieri, Olivier, Langenberg, Claudia, Bouatia-Naji, Nabila, Charpentier, Guillaume, Vaxillaire, Martine, Rocheleau, Ghislain, Wareham, Nicholas J, Sladek, Robert, McCarthy, Mark I, Dina, Christian, Barroso, Inês, Jockers, Ralf, Froguel, Philippe

“…Philippe Froguel, Ralf Jockers and colleagues report the functional characterization of 40 rare protein-coding variants of the MTNR1B gene (encoding melatonin…”
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The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization by Levoye, Angélique, Dam, Julie, Ayoub, Mohammed A, Guillaume, Jean-Luc, Couturier, Cyril, Delagrange, Philippe, Jockers, Ralf

“…One‐third of the ∼400 nonodorant G protein‐coupled receptors (GPCRs) are still orphans. Although a considerable number of these receptors are likely to…”
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Importance of the second extracellular loop for melatonin MT 1 receptor function and absence of melatonin binding in GPR50 by Clement, Nathalie, Renault, Nicolas, Guillaume, Jean-Luc, Cecon, Erika, Journé, Anne-Sophie, Laurent, Xavier, Tadagaki, Kenjiro, Cogé, Francis, Gohier, Arnaud, Delagrange, Philippe, Chavatte, Philippe, Jockers, Ralf

“…Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand binding and gating and…”
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GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors by Ahmad, Raise, Lahuna, Olivier, Sidibe, Anissa, Daulat, Avais, Zhang, Qiang, Luka, Marine, Guillaume, Jean-Luc, Gallet, Sarah, Guillonneau, François, Hamroune, Juliette, Polo, Sophie, Prévot, Vincent, Delagrange, Philippe, Dam, Julie, Jockers, Ralf

“…Transmission of extracellular signals by G protein-coupled receptors typically relies on a cascade of intracellular events initiated by the activation of…”
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Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers by Kamal, Maud, Gbahou, Florence, Guillaume, Jean-Luc, Daulat, Avais M., Benleulmi-Chaachoua, Abla, Luka, Marine, Chen, Patty, Kalbasi Anaraki, Dina, Baroncini, Marc, Mannoury la Cour, Clotilde, Millan, Mark J., Prevot, Vincent, Delagrange, Philippe, Jockers, Ralf

“…Inasmuch as the neurohormone melatonin is synthetically derived from serotonin (5-HT), a close interrelationship between both has long been suspected. The…”
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Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C‐terminal domain by Cecon, Erika, Ivanova, Anna, Luka, Marine, Gbahou, Florence, Friederich, Anne, Guillaume, Jean‐Luc, Keller, Patrick, Knoch, Klaus, Ahmad, Raise, Delagrange, Philippe, Solimena, Michele, Jockers, Ralf

“…Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type…”
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Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50 by Clement, Nathalie, Renault, Nicolas, Guillaume, Jean‐Luc, Cecon, Erika, Journé, Anne‐Sophie, Laurent, Xavier, Tadagaki, Kenjiro, Cogé, Francis, Gohier, Arnaud, Delagrange, Philippe, Chavatte, Philippe, Jockers, Ralf

“…Background and Purpose Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand…”
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The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development by Wojciech, Stefanie, Ahmad, Raise, Belaid-Choucair, Zakia, Journé, Anne-Sophie, Gallet, Sarah, Dam, Julie, Daulat, Avais, Ndiaye-Lobry, Delphine, Lahuna, Olivier, Karamitri, Angeliki, Guillaume, Jean-Luc, Do Cruzeiro, Marcio, Guillonneau, François, Saade, Anastasia, Clément, Nathalie, Courivaud, Thomas, Kaabi, Nawel, Tadagaki, Kenjiro, Delagrange, Philippe, Prévot, Vincent, Hermine, Olivier, Prunier, Céline, Jockers, Ralf

“…Transforming growth factor-β (TGFβ) signaling is initiated by the type I, II TGFβ receptor (TβRI/TβRII) complex. Here we report the formation of an alternative…”
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Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers by Levoye, Angélique, Dam, Julie, Ayoub, Mohammed A, Guillaume, Jean-Luc, Jockers, Ralf

“…G-protein-coupled receptors (GPCRs) are important drug targets and are involved in virtually every biological process. However, there are still more than 140…”
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Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders by Chaste, Pauline, Clement, Nathalie, Botros, Hany Goubran, Guillaume, Jean-Luc, Konyukh, Marina, Pagan, Cécile, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Rastam, Maria, Ståhlberg, Ola, Gillberg, I. Carina, Melke, Jonas, Delorme, Richard, Leblond, Claire, Toro, Roberto, Huguet, Guillaume, Fauchereau, Fabien, Durand, Christelle, Boudarene, Lydia, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Leboyer, Marion, Jockers, Ralf, Gillberg, Christopher, Bourgeron, Thomas

“…:  Melatonin is a powerful antioxidant and a synchronizer of many physiological processes. Alteration in melatonin signaling has been reported in a broad range…”
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GPCR-interacting proteins, major players of GPCR function by Maurice, Pascal, Guillaume, Jean-Luc, Benleulmi-Chaachoua, Abla, Daulat, Avais M, Kamal, Maud, Jockers, Ralf

“…G protein-coupled receptors (GPCRs) are, with approximately 800 members, among the most abundant membrane proteins in humans. They are responding to a plethora…”
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The PDZ Protein Mupp1 Promotes Gi Coupling and Signaling of the Mt1 Melatonin Receptor by Guillaume, Jean-Luc, Daulat, Avais M., Maurice, Pascal, Levoye, Angélique, Migaud, Martine, Brydon, Lena, Malpaux, Benoît, Borg-Capra, Catherine, Jockers, Ralf

“…Intracellular signaling events are often organized around PDZ (PSD-95/Drosophila Disc large/ZO-1 homology) domain-containing scaffolding proteins. The…”
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Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population by Chaste, Pauline, Clement, Nathalie, Mercati, Oriane, Guillaume, Jean-Luc, Delorme, Richard, Botros, Hany Goubran, Pagan, Cécile, Périvier, Samuel, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Rastam, Maria, Ståhlberg, Ola, Gillberg, Carina, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Mouren-Simeoni, Marie Christine, Leboyer, Marion, Gillberg, Christopher, Jockers, Ralf, Bourgeron, Thomas

“…Melatonin is a powerful antioxidant and a synchronizer of many physiological processes. Alteration of the melatonin pathway has been reported in circadian…”
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Purification and Identification of G Protein-coupled Receptor Protein Complexes under Native Conditions by Daulat, Avais M., Maurice, Pascal, Froment, Carine, Guillaume, Jean-Luc, Broussard, Cédric, Monsarrat, Bernard, Delagrange, Philippe, Jockers, Ralf

“…G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors and are of major therapeutic importance. The identification of…”
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A Generic Approach for the Purification of Signaling Complexes That Specifically Interact with the Carboxyl-terminal Domain of G Protein-coupled Receptors by Maurice, Pascal, Daulat, Avais M., Broussard, Cédric, Mozo, Julien, Clary, Guilhem, Hotellier, Françoise, Chafey, Philippe, Guillaume, Jean-Luc, Ferry, Gilles, Boutin, Jean A., Delagrange, Philippe, Camoin, Luc, Jockers, Ralf

“…G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors and are major drug targets. Recent progress has shown that GPCRs are…”
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Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function by Baba, Kenkichi, Benleulmi-Chaachoua, Abla, Journé, Anne-Sophie, Kamal, Maud, Guillaume, Jean-Luc, Dussaud, Sébastien, Gbahou, Florence, Yettou, Katia, Liu, Cuimei, Contreras-Alcantara, Susana, Jockers, Ralf, Tosini, Gianluca

“…The formation of G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR) heteromers enables signaling diversification and holds…”
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Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2 Receptor Variants with Type 2 Diabetes by Karamitri, Angeliki, Renault, Nicolas, Clement, Nathalie, Guillaume, Jean-Luc, Jockers, Ralf

“…The existence of interindividual variations in G protein-coupled receptor sequences has been recognized early on. Recent advances in large-scale exon…”
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Are G protein-coupled receptor heterodimers of physiological relevance?--Focus on melatonin receptors by Levoye, Angélique, Jockers, Ralf, Ayoub, Mohammed A, Delagrange, Philippe, Savaskan, Egemen, Guillaume, Jean-Luc

“…In mammals, the circadian hormone melatonin targets two seven-transmembrane-spanning receptors, MT1 and MT2, of the G protein-coupled receptor (GPCR)…”
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Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling by Maurice, Pascal, Daulat, Avais M, Turecek, Rostislav, Ivankova-Susankova, Klara, Zamponi, Francesco, Kamal, Maud, Clement, Nathalie, Guillaume, Jean-Luc, Bettler, Bernhard, Galès, Céline, Delagrange, Philippe, Jockers, Ralf

“…Functional asymmetry of G‐protein‐coupled receptor (GPCR) dimers has been reported for an increasing number of cases, but the molecular architecture of…”
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