Search Results - "Guiley, Keelan Z."

Structural mechanisms of DREAM complex assembly and regulation by Guiley, Keelan Z, Liban, Tyler J, Felthousen, Jessica G, Ramanan, Parameshwaran, Litovchick, Larisa, Rubin, Seth M

“…The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130…”
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The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes by Asthana, Anushweta, Ramanan, Parameshwaran, Hirschi, Alexander, Guiley, Keelan Z., Wijeratne, Tilini U., Shelansky, Robert, Doody, Michael J., Narasimhan, Haritha, Boeger, Hinrich, Tripathi, Sarvind, Müller, Gerd A., Rubin, Seth M.

“…The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncertain how most transcription factors (TFs) impact nucleosome…”
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Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S) by Zhang, Ziyang, Guiley, Keelan Z., Shokat, Kevan M.

“…Drugs that directly impede the function of driver oncogenes offer exceptional efficacy and a therapeutic window. The recently approved mutant selective…”
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A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability by Guiley, Keelan Z, Shokat, Kevan M

“…The transcription factor and tumor suppressor protein p53 is the most frequently mutated and inactivated gene in cancer. Mutations in p53 result in deregulated…”
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Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D by Zheng, Qinheng, Zhang, Ziyang, Guiley, Keelan Z., Shokat, Kevan M.

“…K-Ras is the most commonly mutated oncogene in human cancer. The recently approved non-small cell lung cancer drugs sotorasib and adagrasib covalently capture…”
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Chemoselective Covalent Modification of K‑Ras(G12R) with a Small Molecule Electrophile by Zhang, Ziyang, Morstein, Johannes, Ecker, Andrew K., Guiley, Keelan Z., Shokat, Kevan M.

“…KRAS mutations are one of the most common oncogenic drivers in human cancer. While small molecule inhibitors for the G12C mutant have been successfully…”
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A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes by Vorster, Paul J, Goetsch, Paul, Wijeratne, Tilini U, Guiley, Keelan Z, Andrejka, Laura, Tripathi, Sarvind, Larson, Braden J, Rubin, Seth M, Strome, Susan, Lipsick, Joseph S

“…The five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB-family tumor suppressor proteins and E2F-DP…”
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p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition by Guiley, Keelan Z, Stevenson, Jack W, Lou, Kevin, Barkovich, Krister J, Kumarasamy, Vishnu, Wijeratne, Tilini U, Bunch, Katharine L, Tripathi, Sarvind, Knudsen, Erik S, Witkiewicz, Agnieszka K, Shokat, Kevan M, Rubin, Seth M

“…The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). Under some…”
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The molecular architecture of human Dicer by Lau, Pick-Wei, Guiley, Keelan Z, De, Nabanita, Potter, Clinton S, Carragher, Bridget, MacRae, Ian J

“…Current understanding of the structure of Dicer is restricted to simple forms of the enzyme from lower eukaryotes or isolated domains from higher eukaryotic…”
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The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb by Iness, Audra N., Felthousen, Jessica, Ananthapadmanabhan, Varsha, Sesay, Fatmata, Saini, Siddharth, Guiley, Keelan Z., Rubin, Seth M., Dozmorov, Mikhail, Litovchick, Larisa

“…Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the…”
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Cyclin-dependent kinase-mediated phosphorylation and the negative regulatory domain of transcription factor B-Myb modulate its DNA binding by Wijeratne, Tilini U., Guiley, Keelan Z., Lee, Hsiau-Wei, Müller, Gerd A., Rubin, Seth M.

“…B-Myb is a highly conserved member of the vertebrate Myb family of transcription factors that plays a critical role in cell-cycle progression and…”
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Structural mechanism of Myb–MuvB assembly by Guiley, Keelan Z., Iness, Audra N., Saini, Siddharth, Tripathi, Sarvind, Lipsick, Joseph S., Litovchick, Larisa, Rubin, Seth M.

“…The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2…”
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Single-pot enzymatic synthesis of Dicer-substrate siRNAs by Guiley, Keelan Z., Pratt, Ashley J., MacRae, Ian J.

“…We describe an inexpensive and efficient method for generating functional pools of Dicer-substrate small interfering RNAs (siRNAs) in a single reaction tube…”
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A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes by Vorster, Paul J, Goetsch, Paul, Wijeratne, Tilini U, Guiley, Keelan Z, Andrejka, Laura, Tripathi, Sarvind, Larson, Braden J, Rubin, Seth M, Strome, Susan, Lipsick, Joseph S

“…The five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB family tumor suppressor proteins and E2F-DP…”
Get full text