Relative safety of 4 weeks of blood flow-restricted resistance exercise in young, healthy adults

This study evaluated the effect of 4 weeks of low‐load resistance exercise with blood flow restriction (BFRE) on increasing strength in comparison with high‐load resistance exercise (HLE), and assessed changes in blood, vascular and neural function. Healthy adults performed leg extension BFRE or HLE...

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Bibliographic Details
Published in:	Scandinavian journal of medicine & science in sports Vol. 21; no. 5; pp. 653 - 662
Main Authors:	Clark, B. C., Manini, T. M., Hoffman, R. L., Williams, P. S., Guiler, M. K., Knutson, M. J., McGLynn, M. L., Kushnick, M. R.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-10-2011
Subjects:	Adaptation, Physiological Adolescent Adult Ankle Brachial Index Blood Flow Velocity C-Reactive Protein - metabolism Exercise Exercise - physiology Female Fibrin Fibrinogen Degradation Products - metabolism Fibrinogen - metabolism Humans KAATSU Leg - blood supply Leg - physiology Male muscle Muscle Strength Muscle, Skeletal - blood supply Muscle, Skeletal - physiology Neural Conduction Prothrombin Time Regional Blood Flow - physiology Resistance Training Safety Tissue Plasminogen Activator - blood vascular occlusion Young Adult Young adults
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Summary:	This study evaluated the effect of 4 weeks of low‐load resistance exercise with blood flow restriction (BFRE) on increasing strength in comparison with high‐load resistance exercise (HLE), and assessed changes in blood, vascular and neural function. Healthy adults performed leg extension BFRE or HLE 3 days/week at 30% and 80% of strength, respectively. During BFRE, a cuff on the upper leg was inflated to 30% above systolic blood pressure. Strength, pulse‐wave velocity (PWV), ankle‐brachial index (ABI), prothrombin time (PT) and nerve conduction (NC) were measured before and after training. Markers of coagulation (fibrinogen and D‐dimer), fibrinolysis [tissue plasminogen activator (tPA)] and inflammation [high sensitivity C‐reactive protein (hsCRP)] were measured in response to the first and last exercise bouts. Strength increased 8% with BFRE and 13% with HLE (P<0.01). No changes in PWV, ABI, PT or NC were observed following training for either group (P>0.05). tPA antigen increased 30–40% immediately following acute bouts of BFRE and HLE (P=0.01). No changes were observed in fibrinogen, D‐dimer or hsCRP (P>0.05). These findings indicate that both protocols increase the strength without altering nerve or vascular function, and that a single bout of both protocols increases fibrinolytic activity without altering selected markers of coagulation or inflammation in healthy individuals.
Bibliography:	istex:D220FB97409672D055A9663AE762C112864B2DCF ark:/67375/WNG-NF52R90L-8 ArticleID:SMS1100 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0905-7188 1600-0838
DOI:	10.1111/j.1600-0838.2010.01100.x