Search Results - "Guijarro, Maria V."

TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background by Guijarro, Maria V., Nawab, Akbar, Dib, Peter, Burkett, Sandra, Luo, Xiaoping, Feely, Michael, Nasri, Elham, Seifert, Robert P., Kaye, Frederic J., Zajac-Kaye, Maria

“…We previously showed that elevated TYMS exhibits oncogenic properties and promotes tumorigenesis after a long latency, suggesting cooperation with sequential…”
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Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence by Acosta, Juan C., O'Loghlen, Ana, Banito, Ana, Guijarro, Maria V., Augert, Arnaud, Raguz, Selina, Fumagalli, Marzia, Da Costa, Marco, Brown, Celia, Popov, Nikolay, Takatsu, Yoshihiro, Melamed, Jonathan, d'Adda di Fagagna, Fabrizio, Bernard, David, Hernando, Eva, Gil, Jesús

“…Cells enter senescence, a state of stable proliferative arrest, in response to a variety of cellular stresses, including telomere erosion, DNA damage, and…”
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MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma by Danielson, Laura S, Guijarro, Maria V, Menendez, Silvia, Higgins, Brett, Sun, Qiang, Mittal, Khushbakhat, Popiolek, Dorota A, Overholtzer, Michael, Palmer, Glyn D, Hernando, Eva

“…Leiomyosarcoma (LMS) is an aggressive, often poorly differentiated cancer of the smooth muscle (SM) lineage for which the molecular drivers of transformation…”
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Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy by Haritha, Nair Hariprasad, Nawab, Akbar, Vijayakurup, Vinod, Anto, Nikhil Ponnoor, Liju, Vijayasteltar B, Alex, Vijai V, Amrutha, Areekkara Nisthul, Aiswarya, Sreekumar U, Swetha, Mundanattu, Vinod, Balachandran S, Sundaram, Sankar, Guijarro, Maria V, Herlevich, Thomas, Krishna, Archana, Nestory, Nesteena K, Bava, Smitha V, Sadasivan, Chittalakkottu, Zajac-Kaye, Maria, Anto, Ruby John

“…The ongoing treatment modalities for breast cancer (BC) primarily rely on the expression status of ER, PR and HER-2 receptors in BC tissues. Our strategy of…”
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A Differentiation-Based MicroRNA Signature Identifies Leiomyosarcoma as a Mesenchymal Stem Cell-Related Malignancy by Danielson, Laura S, Menendez, Silvia, Attolini, Camille Stephan-Otto, Guijarro, Maria V, Bisogna, Maria, Wei, Jianjun, Socci, Nicholas D, Levine, Douglas A, Michor, Franziska, Hernando, Eva

“…Smooth muscle (SM) is a spontaneously contractile tissue that provides physical support and function to organs such as the uterus. Uterine smooth…”
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Corrigendum: Targeting thymidylate synthase enhances the chemosensitivity of triple-negative breast cancer towards 5-FU-based combinatorial therapy by Haritha, Nair Hariprasad, Nawab, Akbar, Vijayakurup, Vinod, Anto, Nikhil Ponnoor, Liju, Vijayasteltar B, Alex, Vijai V, Amrutha, Areekkara Nisthul, Aiswarya, Sreekumar U, Swetha, Mundanattu, Vinod, Balachandran S, Sundaram, Sankar, Guijarro, Maria V, Herlevich, Thomas, Krishna, Archana, Nestory, Nesteena K, Bava, Smitha V, Sadasivan, Chittalakkottu, Zajac-Kaye, Maria, Anto, Ruby John

“…[This corrects the article DOI: 10.3389/fonc.2021.656804.]…”
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Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival by Vijayakurup, Vinod, Maeng, Kyungah, Lee, Hye Seung, Meyer, Benjamin, Burkett, Sandra, Nawab, Akbar, Dougherty, Michael W., Jobin, Christian, Mahmud, Iqbal, Garrett, Timothy J., Feely, Michael, Lee, Kyoung Bun, Kaye, Frederic J., Guijarro, Maria V., Zajac-Kaye, Maria

“…Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome. We…”
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Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells by Guijarro, Maria V, Danielson, Laura S, Cañamero, Marta, Nawab, Akbar, Abrahan, Carolina, Hernando, Eva, Palmer, Glyn D

“…TSC1 is a tumor suppressor that inhibits cell growth via negative regulation of the mammalian target of rapamycin complex (mTORC1). mutations are associated…”
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First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival by Guijarro, Maria V, Kellish, Patrick C, Dib, Peter E, Paciaroni, Nicholas G, Nawab, Akbar, Andring, Jacob, Kulemina, Lidia, Borrero, Nicholas V, Modenutti, Carlos, Feely, Michael, Nasri, Elham, Seifert, Robert P, Luo, Xiaoping, Bennett, Richard L, Shabashvili, Daniil, Licht, Jonathan D, McKenna, Robert, Roitberg, Adrian, Huigens, 3rd, Robert W, Kaye, Frederic J, Zajac-Kaye, Maria

“…Although thymidylate synthase (TYMS) inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS…”
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Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models by Thomas, Ryan M, Gharaibeh, Raad Z, Gauthier, Josee, Beveridge, Mark, Pope, Jillian L, Guijarro, Maria V, Yu, Qin, He, Zhen, Ohland, Christina, Newsome, Rachel, Trevino, Jose, Hughes, Steven J, Reinhard, Mary, Winglee, Kathryn, Fodor, Anthony A, Zajac-Kaye, Maria, Jobin, Christian

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States yet data are scant regarding host factors…”
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MAP17 overexpression is a common characteristic of carcinomas by Guijarro, Maria V., Leal, Juan F.M., Fominaya, Jesus, Blanco-Aparicio, Carmen, Alonso, Soledad, Lleonart, Matilde, Castellvi, Josep, Ruiz, Lidia, Ramon y Cajal, Santiago, Carnero, Amancio

“…We undertook a large-scale genetic screen to identify genes able to alter the cellular response to physiological signals and provide selective advantage once…”
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BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy by SEGURA, Miguel F, FONTANALS-CIRERA, Bárbara, DARVISHIAN, Farbod, OHLMEYER, Michael, OSMAN, Iman, ZHOU, Ming-Ming, HERNANDO, Eva, GAZIEL-SOVRAN, Avital, GUIJARRO, María V, HANNIFORD, Doug, GUANGTAO ZHANG, GONZALEZ-GOMEZ, Pilar, MORANTE, Marta, JUBIERRE, Luz, WEIJIA ZHANG

“…Metastatic melanoma remains a mostly incurable disease. Although newly approved targeted therapies are efficacious in a subset of patients, resistance and…”
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Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival by Kellish, Patrick, Shabashvili, Daniil, Rahman, Masmudur M, Nawab, Akbar, Guijarro, Maria V, Zhang, Min, Cao, Chunxia, Moussatche, Nissin, Boyle, Theresa, Antonia, Scott, Reinhard, Mary, Hartzell, Connor, Jantz, Michael, Mehta, Hiren J, McFadden, Grant, Kaye, Frederic J, Zajac-Kaye, Maria

“…Oncolytic virotherapy has been proposed as an ablative and immunostimulatory treatment strategy for solid tumors that are resistant to immunotherapy alone;…”
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Genome-Wide miRNA Screening for Genes Bypassing Oncogene-Induced Senescence by Guijarro, Maria V, Carnero, Amancio

“…MicroRNAs are small noncoding RNAs that regulate gene expression by binding to sequences within the 3'-UTR of mRNAs. Genome-wide screens have proven powerful…”
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Cardiovascular dysregulation of miR‐17‐92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis by Danielson, Laura S., Park, David S., Rotllan, Noemi, Chamorro‐Jorganes, Aranzazu, Guijarro, Maria V., Fernandez‐Hernando, Carlos, Fishman, Glenn I., Phoon, Colin K. L., Hernando, Eva

“…MicroRNA cluster miR‐17‐92 has been implicated in cardiovascular development and function, yet its precise mechanisms of action in these contexts are…”
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Animal models in osteosarcoma by Guijarro, Maria V, Ghivizzani, Steven C, Gibbs, C Parker

“…Osteosarcoma (OS) is the most common non-hematologic primary tumor of bone in children and adults. High-dose cytotoxic chemotherapy and surgical resection have…”
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Abstract 1188: Forced induction of differentiation in osteosarcoma tumor initiating cells by White, Margaret E., Hyddmark, Emma Viktoria Marie, Zarezadeh, Ali, Nasri, Elham, Guijarro, Maria V., Levings, Padraic P., Palmer, Glyn, Ghivizzani, Steven C., Gibbs, C. Parker

“…Abstract Osteosarcoma (OS) is a highly malignant bone cancer that is defined histologically by the secretion of immature osteoid. The chemotherapeutic regimen…”
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Dual Pten/Tp53 Suppression Promotes Sarcoma Progression by Activating Notch Signaling by Guijarro, Maria V, Dahiya, Sonika, Danielson, Laura S, Segura, Miguel F, Vales-Lara, Frances M, Menendez, Silvia, Popiolek, Dorota, Mittal, Khushbakhat, Wei, Jian Jun, Zavadil, Jiri, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo, Hernando, Eva

“…Soft tissue sarcomas are a heterogeneous group of tumors associated with poor clinical outcome. Although a subset of soft tissue sarcomas is characterized by…”
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Inactivation of Patched1 in Mice Leads to Development of Gastrointestinal Stromal-Like Tumors That Express Pdgfrα but Not Kit by Pelczar, Penelope, Zibat, Arne, van Dop, Willemijn A, Heijmans, Jarom, Bleckmann, Annalen, Gruber, Wolfgang, Nitzki, Frauke, Uhmann, Anja, Guijarro, Maria V, Hernando, Eva, Dittmann, Kai, Wienands, Jürgen, Dressel, Ralf, Wojnowski, Leszek, Binder, Claudia, Taguchi, Takahiro, Beissbarth, Tim, Hogendoorn, Pancras C.W, Antonescu, Cristina R, Rubin, Brian P, Schulz–Schaeffer, Walter, Aberger, Fritz, van den Brink, Gijs R, Hahn, Heidi

“…Background & Aims A fraction of gastrointestinal stromal tumor (GIST) cells overexpress the platelet-derived growth factor receptor (PDGFR)A, although most…”
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FBH1 protects melanocytes from transformation and is deregulated in melanomas by Jeong, Yeon-Tae, Cermak, Lukas, Guijarro, Maria, Hernando, Eva, Pagano, Michele

“…FBH1 is a member of the UvrD family of DNA helicases and plays a crucial role in the response to DNA replication stress. In particular, upon DNA replication…”
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