Search Results - "Guigas, Bruno"

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus by Foretz, Marc, Guigas, Bruno, Viollet, Benoit

“…Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the mechanisms underlying the plasma glucose level-lowering effects of…”
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Role of Mitochondria in the Mechanism(s) of Action of Metformin by Vial, Guillaume, Detaille, Dominique, Guigas, Bruno

“…Metformin is a drug from the biguanide family that is used for decades as the first-line therapeutic choice for the treatment of type 2 diabetes. Despite its…”
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Metformin: From Mechanisms of Action to Therapies by Foretz, Marc, Guigas, Bruno, Bertrand, Luc, Pollak, Michael, Viollet, Benoit

“…Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-lowering effect, there is interest in actions of the drug of…”
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Cellular and molecular mechanisms of metformin: an overview by Viollet, Benoit, Guigas, Bruno, Sanz Garcia, Nieves, Leclerc, Jocelyne, Foretz, Marc, Andreelli, Fabrizio

“…Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of metformin, a potent…”
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The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation by van der Zande, Hendrik J P, Nitsche, Dominik, Schlautmann, Laura, Guigas, Bruno, Burgdorf, Sven

“…The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands…”
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Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes by Vig, Saurabh, Lambooij, Joost M, Zaldumbide, Arnaud, Guigas, Bruno

“…Beta-cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. In response to inflammatory…”
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Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders by Viollet, Benoit, Foretz, Marc, Guigas, Bruno, Horman, Sandrine, Dentin, Renaud, Bertrand, Luc, Hue, Louis, Andreelli, Fabrizio

“…It is now becoming evident that the liver has an important role in the control of whole body metabolism of energy nutrients. In this review, we focus on recent…”
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Editorial: Immune Regulation of Metabolic Homeostasis by Guigas, Bruno, Jourdan, Tony, Stienstra, Rinke

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FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis by Liu, Cong, Schönke, Milena, Spoorenberg, Borah, Lambooij, Joost M, van der Zande, Hendrik J P, Zhou, Enchen, Tushuizen, Maarten E, Andreasson, Anne-Christine, Park, Andrew, Oldham, Stephanie, Uhrbom, Martin, Ahlstedt, Ingela, Ikeda, Yasuhiro, Wallenius, Kristina, Peng, Xiao-Rong, Guigas, Bruno, Boon, Mariëtte R, Wang, Yanan, Rensen, Patrick C N

“…Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH)…”
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A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice by Kuipers, Eline N, Held, Ntsiki M, In Het Panhuis, Wietse, Modder, Melanie, Ruppert, Philip M M, Kersten, Sander, Kooijman, Sander, Guigas, Bruno, Houtkooper, Riekelt H, Rensen, Patrick C N, Boon, Mariëtte R

“…Brown adipose tissue (BAT) catabolizes glucose and fatty acids to produce heat and thereby contributes to energy expenditure. Long-term high-fat diet (HFD)…”
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Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice by GEERLING, Janine J, BOON, Mariëtte R, VAN DER ZON, Gerard C, VAN DEN BERG, Sjoerd A. A, VAN DEN HOEK, Anita M, LOMBES, Marc, PRINCEN, Hans M. G, HAVEKES, Louis M, RENSEN, Patrick C. N, GUIGAS, Bruno

“…Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers…”
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The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice by Buitrago‐Molina, Laura Elisa, Marhenke, Silke, Longerich, Thomas, Sharma, Amar Deep, Boukouris, Aristeidis E., Geffers, Robert, Guigas, Bruno, Manns, Michael P., Vogel, Arndt

“…Hepatocellular carcinoma (HCC) frequently arises in the context of chronic injury that promotes DNA damage and chromosomal aberrations. The cyclin‐dependent…”
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Extracellular vesicles derived from stressed beta cells mediate monocyte activation and contribute to islet inflammation by Dekkers, Mette C, Lambooij, Joost M, Pu, Xudong, Fagundes, Raphael R, Enciso-Martinez, Agustin, Kats, Kim, Giepmans, Ben N G, Guigas, Bruno, Zaldumbide, Arnaud

“…Beta cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. In recent years, the role played by…”
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S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration by Patente, Thiago A, Gasan, Thomas A, Scheenstra, Maaike, Ozir-Fazalalikhan, Arifa, Obieglo, Katja, Schetters, Sjoerd, Verwaerde, Stijn, Vergote, Karl, Otto, Frank, Wilbers, Ruud H P, van Bloois, Eline, Wijck, Yolanda van, Taube, Christian, Hammad, Hamida, Schots, Arjen, Everts, Bart, Yazdanbakhsh, Maria, Guigas, Bruno, Hokke, Cornelis H, Smits, Hermelijn H

“…Chronic infection with Schistosoma mansoni parasites is associated with reduced allergic sensitization in humans, while schistosome eggs protects against…”
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Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity, and glucose homeostasis in obese mice by van der Zande, Hendrik J. P., Lambooij, Joost M., Chavanelle, Vivien, Zawistowska-Deniziak, Anna, Otero, Yolanda, Otto, Frank, Lantier, Louise, McGuinness, Owen P., Le Joubioux, Florian, Giera, Martin, Maugard, Thierry, Peltier, Sébastien L., Sirvent, Pascal, Guigas, Bruno

“…Background/objectives The worldwide prevalence of obesity, metabolic syndrome and type 2 diabetes (T2D) is reaching epidemic proportions that urge the…”
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Infection with Soil-Transmitted Helminths Is Associated with Increased Insulin Sensitivity by Wiria, Aprilianto E, Hamid, Firdaus, Wammes, Linda J, Prasetyani, Margaretta A, Dekkers, Olaf M, May, Linda, Kaisar, Maria M M, Verweij, Jaco J, Guigas, Bruno, Partono, Felix, Sartono, Erliyani, Supali, Taniawati, Yazdanbakhsh, Maria, Smit, Johannes W A

“…Given that helminth infections have been shown to improve insulin sensitivity in animal studies, which may be explained by beneficial effects on energy balance…”
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Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation by Zhou, Enchen, Ge, Xiaoke, Nakashima, Hiroyuki, Li, Rumei, van der Zande, Hendrik J P, Liu, Cong, Li, Zhuang, Müller, Christoph, Bracher, Franz, Mohammed, Yassene, de Boer, Jan Freark, Kuipers, Folkert, Guigas, Bruno, Glass, Christopher K, Rensen, Patrick C N, Giera, Martin, Wang, Yanan

“…Liver X receptor (LXR) agonism has theoretical potential for treating NAFLD/NASH, but synthetic agonists induce hyperlipidemia in preclinical models…”
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Dietary yeast-derived mannan oligosaccharides have immune-modulatory properties but do not improve high fat diet-induced obesity and glucose intolerance by Hoving, Lisa R, van der Zande, Hendrik J P, Pronk, Amanda, Guigas, Bruno, Willems van Dijk, Ko, van Harmelen, Vanessa

“…The indigestible mannan oligosaccharides (MOS) derived from the outer cell wall of yeast Saccharomyces cerevisiae have shown potential to reduce inflammation…”
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Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation by Octave, Marie, Pirotton, Laurence, Ginion, Audrey, Robaux, Valentine, Lepropre, Sophie, Ambroise, Jérôme, Bouzin, Caroline, Guigas, Bruno, Giera, Martin, Foretz, Marc, Bertrand, Luc, Beauloye, Christophe, Horman, Sandrine

“…Acetyl-CoA carboxylase (ACC) is the first enzyme regulating de novo lipid synthesis via the carboxylation of acetyl-CoA into malonyl-CoA. The inhibition of its…”
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Totum-070, a Polyphenol-Rich Plant Extract, Prevents Hypercholesterolemia in High-Fat Diet-Fed Hamsters by Inhibiting Intestinal Cholesterol Absorption by Langhi, Cédric, Vallier, Marie, Otero, Yolanda F, Maura, Maheva, Le Joubioux, Florian, Groult, Hugo, Achour, Oussama, Pebriana, Ratna Budhi, Giera, Martin, Guigas, Bruno, Maugard, Thierry, Chassaing, Benoit, Peltier, Sébastien, Bard, Jean-Marie, Sirvent, Pascal

“…Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide, and hypercholesterolemia is a central risk factor for atherosclerosis. This…”
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