Search Results - "Guido T. Bommer"

MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells by Ji, Qing, Hao, Xinbao, Zhang, Min, Tang, Wenhua, Yang, Meng, Li, Ling, Xiang, Debing, Desano, Jeffrey T, Bommer, Guido T, Fan, Daiming, Fearon, Eric R, Lawrence, Theodore S, Xu, Liang

“…MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell…”
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Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation by Gerin, Isabelle, Clerbaux, Laure-Alix, Haumont, Olivier, Lanthier, Nicolas, Das, Arun K., Burant, Charles F., Leclercq, Isabelle A., MacDougald, Ormond A., Bommer, Guido T.

“…The regulation of synthesis, degradation, and distribution of lipids is crucial for homeostasis of organisms and cells. The sterol regulatory element-binding…”
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Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus by Bommer, Guido T., MacDougald, Ormond A.

“…The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved…”
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Roles for miRNA-378/378 in adipocyte gene expression and lipogenesis by Gerin, Isabelle, Bommer, Guido T, McCoin, Colin S, Sousa, Kyle M, Krishnan, Venkatesh, MacDougald, Ormond A

“…In this study, we explored the roles of microRNAs in adipocyte differentiation and metabolism. We first knocked down Argonaute2 (Ago2), a key enzyme in the…”
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Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19 by Dewulf, Joseph P., Martin, Manon, Marie, Sandrine, Oguz, Fabie, Belkhir, Leila, De Greef, Julien, Yombi, Jean Cyr, Wittebole, Xavier, Laterre, Pierre-François, Jadoul, Michel, Gatto, Laurent, Bommer, Guido T., Morelle, Johann

“…SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for…”
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ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan by Gerin, Isabelle, Ury, Benoît, Breloy, Isabelle, Bouchet-Seraphin, Céline, Bolsée, Jennifer, Halbout, Mathias, Graff, Julie, Vertommen, Didier, Muccioli, Giulio G., Seta, Nathalie, Cuisset, Jean-Marie, Dabaj, Ivana, Quijano-Roy, Susana, Grahn, Ammi, Van Schaftingen, Emile, Bommer, Guido T.

“…Mutations in genes required for the glycosylation of α-dystroglycan lead to muscle and brain diseases known as dystroglycanopathies. However, the precise…”
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The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi by Ury, Benoît, Potelle, Sven, Caligiore, Francesco, Whorton, Matthew R., Bommer, Guido T.

“…The glycoprotein α-dystroglycan helps to link the intracellular cytoskeleton to the extracellular matrix. A unique glycan structure attached to this protein is…”
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p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes by Bommer, Guido T., Gerin, Isabelle, Feng, Ying, Kaczorowski, Andrew J., Kuick, Rork, Love, Robert E., Zhai, Yali, Giordano, Thomas J., Qin, Zhaohui S., Moore, Bethany B., MacDougald, Ormond A., Cho, Kathleen R., Fearon, Eric R.

“…In response to varied cell stress signals, the p53 tumor-suppressor protein activates a multitude of genes encoding proteins with functions in cell-cycle…”
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The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases by Kentache, Takfarinas, Thabault, Léopold, Peracchi, Alessio, Frédérick, Raphaël, Bommer, Guido T, Van Schaftingen, Emile

“…Homologues of the putative dehydrogenase YjhC are found in operons involved in the metabolism of N-acetylneuraminate (Neu5Ac) or related compounds. We observed…”
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Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase by Gerin, Isabelle, Noël, Gaëtane, Bolsée, Jennifer, Haumont, Olivier, Van Schaftingen, Emile, Bommer, Guido T

“…The p53-induced protein TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is considered to be a F26BPase…”
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Sox9 Induction, Ectopic Paneth Cells, and Mitotic Spindle Axis Defects in Mouse Colon Adenomatous Epithelium Arising From Conditional Biallelic Apc Inactivation by Feng, Ying, Sentani, Kazuhiro, Wiese, Alexandra, Sands, Evan, Green, Maranne, Bommer, Guido T, Cho, Kathleen R, Fearon, Eric R

“…We generated transgenic mice in which human CDX2 gene elements control expression of a tamoxifen-regulated Cre protein ( CDX2P-CreER T2 ) to allow for…”
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Prebiotic approach alleviates hepatic steatosis: Implication of fatty acid oxidative and cholesterol synthesis pathways by Pachikian, Barbara D., Essaghir, Ahmed, Demoulin, Jean-Baptiste, Catry, Emilie, Neyrinck, Audrey M., Dewulf, Evelyne M., Sohet, Florence M., Portois, Laurence, Clerbaux, Laure-Alix, Carpentier, Yvon A., Possemiers, Sam, Bommer, Guido T., Cani, Patrice D., Delzenne, Nathalie M.

“…Scope Recent data suggest that gut microbiota contributes to the regulation of host lipid metabolism. We report how fermentable dietary fructo‐oligosaccharides…”
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Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs by Rowe, R. Grant, Li, Xiao-Yan, Hu, Yuexian, Saunders, Thomas L, Virtanen, Ismo, de Herreros, Antonio Garcia, Becker, Karl-Friedrich, Ingvarsen, Signe, Engelholm, Lars H, Bommer, Guido T, Fearon, Eric R, Weiss, Stephen J

“…Epithelial-mesenchymal transition (EMT) is required for mesodermal differentiation during development. The zinc-finger transcription factor, Snail1, can…”
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Ethylmalonyl-CoA Decarboxylase, a New Enzyme Involved in Metabolite Proofreading by Linster, Carole L., Noël, Gaëtane, Stroobant, Vincent, Vertommen, Didier, Vincent, Marie-Françoise, Bommer, Guido T., Veiga-da-Cunha, Maria, Van Schaftingen, Emile

“…A limited number of enzymes are known that play a role analogous to DNA proofreading by eliminating non-classical metabolites formed by side activities of…”
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Loss of Estrogen Receptor 1 Enhances Cervical Cancer Invasion by Zhai, Yali, Bommer, Guido T, Feng, Ying, Wiese, Alexandra B, Fearon, Eric R, Cho, Kathleen R

“…If left untreated, some cervical high-grade squamous intraepithelial lesions will progress to invasive squamous cell carcinoma (SCC), but the molecular events…”
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On the Role of FOX Transcription Factors in Adipocyte Differentiation and Insulin-stimulated Glucose Uptake by Gerin, Isabelle, Bommer, Guido T., Lidell, Martin E., Cederberg, Anna, Enerback, Sven, MacDougald, Ormond A.

“…In this study, we explore the effects of several FOX and mutant FOX transcription factors on adipocyte determination, differentiation, and metabolism. In…”
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Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis by Bommer, Guido T., Van Schaftingen, Emile, Veiga-da-Cunha, Maria

“…Hundreds of metabolic enzymes work together smoothly in a cell. These enzymes are highly specific. Nevertheless, under physiological conditions, many perform…”
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Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer by Lenhard, Konstanze, Bommer, Guido T, Asutay, Silke, Schauer, Rolf, Brabletz, Thomas, Göke, Burkhard, Lamerz, Rolf, Kolligs, Frank T

“…Detection of tumor-derived DNA alterations in stool is an intriguing new approach with high potential for the noninvasive detection of colorectal cancer (CRC)…”
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Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite by Heremans, Isaac P, Caligiore, Francesco, Gerin, Isabelle, Bury, Marina, Lutz, Marilena, Graff, Julie, Stroobant, Vincent, Vertommen, Didier, Teleman, Aurelio A, Van Schaftingen, Emile, Bommer, Guido T

“…Cells are continuously exposed to potentially dangerous compounds. Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases…”
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Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency by Veiga-da-Cunha, Maria, Chevalier, Nathalie, Stephenne, Xavier, Defour, Jean-Philippe, Paczia, Nicole, Ferster, Alina, Achouri, Younes, Dewulf, Joseph P., Linster, Carole L., Bommer, Guido T., Van Schaftingen, Emile

“…Neutropenia represents an important problem in patients with genetic deficiency in either the glucose-6-phosphate transporter of the endoplasmic reticulum…”
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