Search Results - "Guido, Carpino"
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Anatomical, histomorphological and molecular classification of cholangiocarcinoma
Published in Liver international (01-05-2019)“…Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at any point of the biliary tree. Cholangiocarcinoma is classified into…”
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2
The hepatic, biliary, and pancreatic network of stem/progenitor cell niches in humans: A new reference frame for disease and regeneration
Published in Hepatology (Baltimore, Md.) (01-07-2016)“…Stem/progenitors for liver, biliary tree, and pancreas exist at early stages of development in the definitive ventral endoderm forming the foregut. In humans,…”
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3
Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD
Published in Hepatology (Baltimore, Md.) (01-08-2020)“…Background and Aims Lipopolysaccharides (LPS) is increased in nonalcoholic fatty liver disease (NAFLD), but its relationship with liver inflammation is not…”
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4
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Published in Nature reviews. Gastroenterology & hepatology (01-09-2020)“…Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence…”
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Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Published in Nature reviews. Gastroenterology & hepatology (01-05-2016)“…Cholangiocarcinomas are a heterogeneous group of bile duct cancers and the second most common primary liver tumour worldwide. In this Consensus statement, the…”
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Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases
Published in Oxidative medicine and cellular longevity (01-01-2017)“…GSK-3 is a ubiquitously expressed serine/threonine kinase existing as GSK-3α and GSK-3β isoforms, both active under basal conditions and inactivated upon…”
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7
The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications
Published in Mediators of inflammation (2017)“…The obese phenotype is characterized by a state of chronic low-grade systemic inflammation that contributes to the development of comorbidities, including…”
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8
Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease
Published in PloS one (04-02-2014)“…Nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of liver-related morbidity and mortality in children. Recently, we have reported…”
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9
Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease
Published in Hepatology (Baltimore, Md.) (01-12-2012)“…Hepatic progenitor cells (HPCs) play a major role in liver repair and regeneration. We evaluated HPC involvement in pediatric nonalcoholic fatty liver disease…”
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10
Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis
Published in The American journal of pathology (01-03-2018)“…Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are human primary cholangiopathies characterized by the damage of mature…”
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Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial
Published in PloS one (15-12-2016)“…There are no licensed treatments for non alcoholic fatty liver disease (NAFLD) in adults or children. In NAFLD, several studies have shown a benefit of omega-3…”
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12
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
Published in Journal of hepatology (01-11-2015)“…Background & Aims Primary sclerosing cholangitis (PSC) is characterised by fibro-stenosing strictures involving extrahepatic and/or large intrahepatic bile…”
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13
The biliary tree—a reservoir of multipotent stem cells
Published in Nature reviews. Gastroenterology & hepatology (01-04-2012)“…This Perspectives describes the characteristics of stem and progenitor cells in the liver, biliary tree and pancreas. A hypothetical model of maturational cell…”
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14
Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis
Published in Cells (Basel, Switzerland) (02-03-2020)“…Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by lipid accumulation in hepatocytes in the absence of excessive alcohol…”
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15
Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis
Published in Hepatology (Baltimore, Md.) (01-03-2020)“…Background and Aims Mechanisms underlying the repair of extrahepatic biliary tree (EHBT) after injury have been scarcely explored. The aims of this study were…”
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16
Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets
Published in Hepatology (Baltimore, Md.) (01-12-2011)“…Multipotent stem/progenitors are present in peribiliary glands of extrahepatic biliary trees from humans of all ages and in high numbers in hepato‐pancreatic…”
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17
Metformin exerts anti-cancerogenic effects and reverses epithelial-to-mesenchymal transition trait in primary human intrahepatic cholangiocarcinoma cells
Published in Scientific reports (28-01-2021)“…Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with marked resistance to chemotherapeutics without therapies. The tumour microenvironment…”
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18
Effect of Calcium-Sulphate-Bicarbonate Water in a Murine Model of Non-Alcoholic Fatty Liver Disease: A Histopathology Study
Published in International journal of molecular sciences (01-09-2022)“…The progression of nonalcoholic fatty liver disease (NAFLD) is associated with alterations of the gut–liver axis. The activation of toll-like receptor 4 (TLR4)…”
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Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks
Published in International journal of molecular sciences (09-10-2013)“…Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of diseases ranging from simple fatty liver to nonalcoholic steatohepatitis, (NASH) which may…”
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Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages
Published in Journal of anatomy (01-02-2012)“…Stem/progenitors have been identified intrahepatically in the canals of Hering and extrahepatically in glands of the biliary tree. Glands of the biliary tree…”
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