Search Results - "Guicciardi, Maria E"

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis by Kakisaka, Keisuke, Cazanave, Sophie C, Fingas, Christian D, Guicciardi, Maria E, Bronk, Steven F, Werneburg, Nathan W, Mott, Justin L, Gores, Gregory J

“…Isolated hepatocytes undergo lipoapoptosis, a feature of hepatic lipotoxicity, on treatment with saturated free fatty acids (FFA) such as palmitate (PA)…”
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NOTCH3 expression is linked to breast cancer seeding and distant metastasis by Leontovich, Alexey A, Jalalirad, Mohammad, Salisbury, Jeffrey L, Mills, Lisa, Haddox, Candace, Schroeder, Mark, Tuma, Ann, Guicciardi, Maria E, Zammataro, Luca, Gambino, Mario W, Amato, Angela, Di Leonardo, Aldo, McCubrey, James, Lange, Carol A, Liu, Minetta, Haddad, Tufia, Goetz, Matthew, Boughey, Judy, Sarkaria, Jann, Wang, Liewei, Ingle, James N, Galanis, Evanthia, D'Assoro, Antonino B

“…Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of…”
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Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice by Feldstein, Ariel E, Canbay, Ali, Guicciardi, Maria E, Higuchi, Hajime, Bronk, Steven F, Gores, Gregory J

“…Background/Aims: Hepatic steatosis sensitizes the liver to injury and inflammation by unclear mechanisms. Because Fas has been linked to liver injury and…”
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A smac mimetic reduces TNF Related Apoptosis Inducing Ligand (TRAIL)‐induced invasion and metastasis of cholangiocarcinoma cells by Fingas, Christian D., Blechacz, Boris R. A., Smoot, Rory L., Guicciardi, Maria E., Mott, Justin, Bronk, Steve F., Werneburg, Nathan W., Sirica, Alphonse E., Gores, Gregory J.

“…Cholangiocarcinoma (CCA) cells paradoxically express tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL), a death ligand that, failing to kill CCA…”
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Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells by Kurita, Satoshi, Mott, Justin L, Cazanave, Sophie C, Fingas, Christian D, Guicciardi, Maria E, Bronk, Steve F, Roberts, Lewis R, Fernandez-Zapico, Martin E, Gores, Gregory J

“…TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor…”
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Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4−/− Mouse by Krishnan, Anuradha, Katsumi, Tomohiro, Guicciardi, Maria E., Azad, Adiba I., Ozturk, Nazli B., Trussoni, Christy E., Gores, Gregory J.

“…The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL; TNFSF10) receptor (TR) is a pro-apoptotic receptor whose contribution to chronic…”
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Myofibroblast‐derived PDGF‐BB promotes hedgehog survival signaling in cholangiocarcinoma cells by Fingas, Christian D., Bronk, Steven F., Werneburg, Nathan W., Mott, Justin L., Guicciardi, Maria E., Cazanave, Sophie C., Mertens, Joachim C., Sirica, Alphonse E., Gores, Gregory J.

“…Cholangiocarcinoma (CCA) cells paradoxically express the death ligand, tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL) and, therefore, are…”
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A Klothoβ Variant Mediates Protein Stability and Associates With Colon Transit in Irritable Bowel Syndrome With Diarrhea by Wong, Banny S, Camilleri, Michael, Carlson, Paula J, Guicciardi, Maria E, Burton, Duane, McKinzie, Sanna, Rao, Archana S, Zinsmeister, Alan R, Gores, Gregory J

“…Background & Aims Bile acid (BA) malabsorption of moderate severity is reported in 32% of patients with chronic unexplained diarrhea, including…”
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IL-17 signaling in primary sclerosing cholangitis patient-derived organoids by Garcia Moreno, Ana S, Guicciardi, Maria E, Wixom, Alexander Q, Jessen, Erik, Yang, Jingchun, Ilyas, Sumera I, Bianchi, Jackie K, Pinto E Vairo, Filippo, Lazaridis, Konstantinos N, Gores, Gregory J

“…The pathogenesis of primary sclerosing cholangitis (PSC) is unclear, although studies implicate IL-17A as an inflammatory mediator in this disease. However, a…”
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Caveolin-1 Can Regulate Vascular Smooth Muscle Cell Fate by Switching Platelet-Derived Growth Factor Signaling From a Proliferative to an Apoptotic Pathway by Peterson, Timothy E, Guicciardi, Maria E, Gulati, Rajiv, Kleppe, Laurel S, Mueske, Cheryl S, Mookadam, Martina, Sowa, Grzegorz, Gores, Gregory J, Sessa, William C, Simari, Robert D

“…BACKGROUND—Caveolin-1 is a regulator of signaling events originating from plasma membrane microdomains termed caveolae. This study was performed to determine…”
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Overexpression of Mcl-1 Attenuates Liver Injury and Fibrosis in the Bile Duct-Ligated Mouse by Kahraman, Alisan, Mott, Justin L, Bronk, Steven F, Werneburg, Nathan W, Barreyro, Fernando J, Guicciardi, Maria E, Akazawa, Yuko, Braley, Karen, Craig, Ruth W, Gores, Gregory J

“…Hepatocyte apoptosis contributes to liver injury and fibrosis after cholestatic injury. Our aim was to ascertain if the anti-apoptotic protein Mcl-1 alters…”
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Abstract 4105: Hedgehog inhibition promotes type I TRAIL cytotoxicity in human cholangiocarcinoma cells by Kurita, Satoshi, Mott, Justin L., Fernandez-Zapico, Martin E., Bronk, Steve F., Guicciardi, Maria E., Roberts, Lewis R., Hibi, Toshifumi, Gores, Gregory J.

“…Abstract [Background and Aim] TRAIL is a promising therapeutic agent for human malignancies that can activate apoptosis via mitochondria-independent (Type I)…”
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Cathepsin B inactivation attenuates hepatic apoptosis and fibrosis during cholestasis by Canbay, Ali, Higuchi, Hajime, Guicciardi, Maria E., Bronk, Steven F., Feldstein, Ariel, Taniai, Makiko, Rydzewski, Robert M., Gores, Gregory J.

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