Search Results - "Guicciardi, M. Eugenia"

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Activates a Lysosomal Pathway of Apoptosis That Is Regulated by Bcl-2 Proteins by Werneburg, Nathan W., Guicciardi, M. Eugenia, Bronk, Steve F., Kaufmann, Scott H., Gores, Gregory J.

“…The present studies were performed to determine whether lysosomal permeabilization contributes to tumor necrosis factor-related apoptosis-inducing ligand…”
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Ursodeoxycholic acid cytoprotection: Dancing with death receptors and survival pathways by Guicciardi, M.Eugenia, Gores, Gregory J.

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Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent by Werneburg, Nathan W, Guicciardi, M Eugenia, Bronk, Steven F, Gores, Gregory J

“…Cathepsin B (Cat B) is released from lysososomes during tumor necrosis factor-alpha (TNF-alpha) cytotoxic signaling in hepatocytes and contributes to cell…”
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Targeted use of siRNA in animal models of hepatic damage: an innovative therapy for acute liver failure by Eugenia Guicciardi, M, Gores, Gregory J

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TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent by Werneburg, Nate, Guicciardi, M Eugenia, Yin, Xiao-Ming, Gores, Gregory J

“…TNF-alpha cytotoxic signaling involves lysosomal permeabilization with release of the lysosomal protease cathepsin B (ctsb) into the cytosol. However, the…”
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Bid Is Upstream of Lysosome-Mediated Caspase 2 Activation in Tumor Necrosis Factor α–Induced Hepatocyte Apoptosis by Guicciardi, M. Eugenia, Bronk, Steven F., Werneburg, Nathan W., Yin, Xiao-Ming, Gores, Gregory J.

“…Background & Aims: During tumor necrosis factor α–mediated hepatocyte cytotoxicity, cathepsin B is released from lysosomes and contributes to apoptosis by…”
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Cell stress gives a red light to the mitochondrial cell death pathway by Guicciardi, M Eugenia, Gores, Gregory J

“…Although the ultimate outcome of prolonged exposure of cells to stress is often death, the early response appears to be the activation of survival pathways…”
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AIP1: a new player in TNF signaling by Guicciardi, M Eugenia, Gores, Gregory J

“…Apoptosis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows that the ASK1-interacting…”
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Cheating death in the liver by Guicciardi, M Eugenia, Gores, Gregory J

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NF-{{kappa}}B Is Activated in Cholestasis and Functions to Reduce Liver Injury by Miyoshi, Hideyuki, Rust, Christian, Guicciardi, M. Eugenia, Gores, Gregory J

“…Selected bile acids activate a nuclear factor-kappa B (NF-kappaB)-dependent survival signaling cascade in cultured hepatocytes. These data suggest that in…”
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Dying in Fas traffic by Guicciardi, M. Eugenia, Gores, Gregory J.

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Is ursodeoxycholate an antiapoptotic drug? by Guicciardi, M. Eugenia, Gores, Gregory J.

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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c by Guicciardi, M E, Deussing, J, Miyoshi, H, Bronk, S F, Svingen, P A, Peters, C, Kaufmann, S H, Gores, G J

“…TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine protease, has recently been…”
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Short-term effects of simvastatin on bile acid synthesis and bile lipid secretion in human subjects by Loria, P, Bertolotti, M, Cassinadri, M T, Dilengite, M A, Bozzoli, M, Carubbi, F, Concari, M, Guicciardi, M E, Carulli, N

“…To test whether de novo synthesis of cholesterol is a limiting factor for bile acid synthesis, we studied the acute effect of simvastatin, an inhibitor of…”
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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas by Faubion, W A, Guicciardi, M E, Miyoshi, H, Bronk, S F, Roberts, P J, Svingen, P A, Kaufmann, S H, Gores, G J

“…Cholestatic liver injury appears to result from the induction of hepatocyte apoptosis by toxic bile salts such as glycochenodeoxycholate (GCDC). Previous…”
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NF-κB Is Activated in Cholestasis and Functions to Reduce Liver Injury by Miyoshi, Hideyuki, Rust, Christian, Guicciardi, M. Eugenia, Gores, Gregory J.

“…Selected bile acids activate a nuclear factor-kappa B (NF-κB)-dependent survival signaling cascade in cultured hepatocytes. These data suggest that in…”
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5 Rab7 Dependent DR5 Trafficking to Lysosomes Is Required for the Lysosomal Pathway of TRAIL Mediated Apoptosis by Akazawa, Yuko, Mott, Justin L, Bronk, Steven F, Werneburg, Nathan W, Guicciardi, M. Eugenia, Meng, Xue, McNiven, Mark A, Gores, Gregory J

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Calpains Can Do It Alone: Implications for Cancer Therapy by guicciardi, maria eugenia, Gores, Gregory

“…Commentary to: Mu-Calpain Activation in Beta-Lapachone-Mediated Apoptosis Colleen Tagliarino, John J. Pink, Kathryn Reinicke, Sara M. Simmers and David A…”
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Effects of Different Phenotypes of Hyperlipoproteinemia and of Treatment With Fibric Acid Derivatives on the Rates of Cholesterol 7 alpha-Hydroxylation in Humans by Bertolotti, Marco, Concari, Mauro, Loria, Paola, Abate, Nicola, Pinetti, Adriano, Guicciardi, M. Eugenia, Carulli, Nicola

“…Little is known about the relationships between hyperlipidemia and bile acid metabolism. However, hypolipidemic treatment with fibric acid derivatives has been…”
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