Search Results - "Guicciardi, M."

Apoptosis: a mechanism of acute and chronic liver injury by Guicciardi, M E, Gores, G J

“…19 Apoptosis of liver cells has now been linked to liver fibrosis in several studies. [...]the physiological concept that liver cell apoptosis is "innocuous"…”
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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c by Guicciardi, M E, Deussing, J, Miyoshi, H, Bronk, S F, Svingen, P A, Peters, C, Kaufmann, S H, Gores, G J

“…TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine protease, has recently been…”
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Tumor Necrosis Factor-related Apoptosis-inducing Ligand Activates a Lysosomal Pathway of Apoptosis That Is Regulated by Bcl-2 Proteins by Werneburg, Nathan W., Guicciardi, M. Eugenia, Bronk, Steve F., Kaufmann, Scott H., Gores, Gregory J.

“…The present studies were performed to determine whether lysosomal permeabilization contributes to tumor necrosis factor-related apoptosis-inducing ligand…”
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Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent by Werneburg, Nathan W, Guicciardi, M Eugenia, Bronk, Steven F, Gores, Gregory J

“…Cathepsin B (Cat B) is released from lysososomes during tumor necrosis factor-alpha (TNF-alpha) cytotoxic signaling in hepatocytes and contributes to cell…”
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TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent by Werneburg, Nate, Guicciardi, M Eugenia, Yin, Xiao-Ming, Gores, Gregory J

“…TNF-alpha cytotoxic signaling involves lysosomal permeabilization with release of the lysosomal protease cathepsin B (ctsb) into the cytosol. However, the…”
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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas by Faubion, W A, Guicciardi, M E, Miyoshi, H, Bronk, S F, Roberts, P J, Svingen, P A, Kaufmann, S H, Gores, G J

“…Cholestatic liver injury appears to result from the induction of hepatocyte apoptosis by toxic bile salts such as glycochenodeoxycholate (GCDC). Previous…”
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Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury by Baskin-Bey, E S, Canbay, A, Bronk, S F, Werneburg, N, Guicciardi, M E, Nyberg, S L, Gores, G J

“…Hepatic steatosis predisposes the liver to cold ischemia-warm reperfusion (CI/WR) injury by unclear mechanisms. Because hepatic steatosis has recently been…”
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Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications by Guicciardi, M E, Miyoshi, H, Bronk, S F, Gores, G J

“…Tumor necrosis factor-alpha (TNF-alpha) contributes to liver injury by inducing hepatocyte apoptosis. Recent evidence suggests that cathepsin B (cat B)…”
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Bid Is Upstream of Lysosome-Mediated Caspase 2 Activation in Tumor Necrosis Factor α–Induced Hepatocyte Apoptosis by Guicciardi, M. Eugenia, Bronk, Steven F., Werneburg, Nathan W., Yin, Xiao-Ming, Gores, Gregory J.

“…Background & Aims: During tumor necrosis factor α–mediated hepatocyte cytotoxicity, cathepsin B is released from lysosomes and contributes to apoptosis by…”
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P.05.1 ENDOSCOPIC REMOVAL OF A LARGE SYMPTOMATIC IMPACTED BONE IN THE COLON by Limido, E, Bassino, C, Tettamanzi, D, Sala, D, Golia, M, Azzola, Guicciardi M, Gerosa, P

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P.11.10 ISCHEMIC COLITIS INDUCED BY COLONOSCOPY PREPARATION. REPORT OF A CASE by Limido, E, Golia, M, Azzola Guicciardi, M, De Marco, A, Misitano, P, Sala, D

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Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease by Guicciardi, M.E., Gores, G.J.

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Cell stress gives a red light to the mitochondrial cell death pathway by Guicciardi, M Eugenia, Gores, Gregory J

“…Although the ultimate outcome of prolonged exposure of cells to stress is often death, the early response appears to be the activation of survival pathways…”
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AIP1: a new player in TNF signaling by Guicciardi, M Eugenia, Gores, Gregory J

“…Apoptosis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows that the ASK1-interacting…”
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Ursodeoxycholic acid cytoprotection: Dancing with death receptors and survival pathways by Guicciardi, M.Eugenia, Gores, Gregory J.

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Cheating death in the liver by Guicciardi, M Eugenia, Gores, Gregory J

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Targeted use of siRNA in animal models of hepatic damage: an innovative therapy for acute liver failure by Eugenia Guicciardi, M, Gores, Gregory J

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NF-κB Is Activated in Cholestasis and Functions to Reduce Liver Injury by Miyoshi, Hideyuki, Rust, Christian, Guicciardi, M. Eugenia, Gores, Gregory J.

“…Selected bile acids activate a nuclear factor-kappa B (NF-κB)-dependent survival signaling cascade in cultured hepatocytes. These data suggest that in…”
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Is ursodeoxycholate an antiapoptotic drug? by Guicciardi, M. Eugenia, Gores, Gregory J.

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114 Cathepsin B activates caspase-2 to promote hepatocyte apoptosis upon the TNF-alpha treatment by Guicciardi, M., Bronk, S.F., Gores, G.J.

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