Search Results - "Guha, Somraj"

Metal‐Free Halogen(I) Catalysts for the Oxidation of Aryl(heteroaryl)methanes to Ketones or Esters: Selectivity Control by Halogen Bonding by Guha, Somraj, Sekar, Govindasamy

“…Metal‐free halogen(I) catalysts were used for the selective oxidation of aryl(heteroaryl)methanes [C(sp3)−H] to ketones [C(sp2)=O] or esters [C(sp3)−O]. The…”
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Role of Lewis‐Base‐Coordinated Halogen(I) Intermediates in Organic Synthesis: The Journey from Unstable Intermediates to Versatile Reagents by Guha, Somraj, Kazi, Imran, Nandy, Anuradha, Sekar, Govindasamy

“…The widespread use of halogen‐based reagents in organic synthesis is well known. Hypervalent halogens (oxidation states III and V) have been explored to a…”
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Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria by Junk, Lukas, Schmiedel, Volker M., Guha, Somraj, Fischel, Katharina, Greb, Peter, Vill, Kristin, Krisilia, Violetta, van Geelen, Lasse, Rumpel, Klaus, Kaur, Parvinder, Krishnamurthy, Ramya V., Narayanan, Shridhar, Shandil, Radha Krishan, Singh, Mayas, Kofink, Christiane, Mantoulidis, Andreas, Biber, Philipp, Gmaschitz, Gerhard, Kazmaier, Uli, Meinhart, Anton, Leodolter, Julia, Hoi, David, Junker, Sabryna, Morreale, Francesca Ester, Clausen, Tim, Kalscheuer, Rainer, Weinstabl, Harald, Boehmelt, Guido

“…Antimicrobial resistance is a global health threat that requires the development of new treatment concepts. These should not only overcome existing resistance…”
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CBr4 as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones by Kazi, Imran, Guha, Somraj, Sekar, Govindasamy

“…CBr4 has been employed as a halogen bond donor catalyst for the selective activation of aldehyde, to achieve an efficient solvent- and metal-free CC bond…”
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Visible-Light-Driven Halogen-Bond-Assisted Direct Synthesis of Heteroaryl Thioethers Using Transition-Metal-Free One-Pot C–I Bond Formation/C–S Cross-Coupling Reaction by Nandy, Anuradha, Kazi, Imran, Guha, Somraj, Sekar, Govindasamy

“…An efficient protocol for the synthesis of thioether directly from heteroarenes has been developed in the presence of visible light in a one-pot manner at room…”
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Proton-Coupled Electron Transfer: Transition-Metal-Free Selective Reduction of Chalcones and Alkynes Using Xanthate/Formic Acid by Prasanna, Ramanathan, Guha, Somraj, Sekar, Govindasamy

“…Highly chemoselective reduction of α,β-unsaturated ketones to saturated ketones and stereoselective reduction of alkynes to (E)-alkenes has been developed…”
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Halogen Bond-Assisted Electron-Catalyzed Atom Economic Iodination of Heteroarenes at Room Temperature by Kazi, Imran, Guha, Somraj, Sekar, Govindasamy

“…A halogen bond-assisted electron-catalyzed iodination of heteroarenes has been developed for the first time under atom economic condition at room temperature…”
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Iodonium IonCatalyzed Domino Synthesis of Z‑Selective α,β-Diphenylthio Enones from Easily Accessible Secondary Alcohols by Sundaravelu, Nallappan, Guha, Somraj, Sekar, Govindasamy

“…The application of stabilized iodonium ions in organic synthesis remains largely unexplored. Herein, a metal-free domino synthesis of Z-selective…”
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A Versatile and One-Pot Strategy to Synthesize α‑Amino Ketones from Benzylic Secondary Alcohols Using N‑Bromosuccinimide by Guha, Somraj, Rajeshkumar, Venkatachalam, Kotha, Surya Srinivas, Sekar, Govindasamy

“…A metal-free one-pot strategy has been developed for the first time to synthesize pharmaceutically important α-amino ketones from readily available benzylic…”
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Iodine-Promoted Controlled and Selective Oxidation of (Aryl)(Heteroaryl)Methanes by Guha, Somraj, Kazi, Imran, Sathish, Dhamodharan, Sekar, Govindasamy

“…The development of direct and controlled oxidation of C(sp3)–H bonds is of great importance. Herein, an iodine-catalyzed controlled oxidation of…”
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BacPROTACs mediate targeted protein degradation in bacteria by Morreale, Francesca E., Kleine, Stefan, Leodolter, Julia, Junker, Sabryna, Hoi, David M., Ovchinnikov, Stepan, Okun, Anastasia, Kley, Juliane, Kurzbauer, Robert, Junk, Lukas, Guha, Somraj, Podlesainski, David, Kazmaier, Uli, Boehmelt, Guido, Weinstabl, Harald, Rumpel, Klaus, Schmiedel, Volker M., Hartl, Markus, Haselbach, David, Meinhart, Anton, Kaiser, Markus, Clausen, Tim

“…Hijacking the cellular protein degradation system offers unique opportunities for drug discovery, as exemplified by proteolysis-targeting chimeras. Despite…”
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CBr 4 as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones by Kazi, Imran, Guha, Somraj, Sekar, Govindasamy

“…CBr has been employed as a halogen bond donor catalyst for the selective activation of aldehyde, to achieve an efficient solvent- and metal-free C═C bond…”
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Aldosterone Glucuronide, an Important Biomarker: Synthesis and Structure Elucidation of Novel Isomers by Guha, Somraj, Senthilkumar, Soundararasu, Voß, Edgar, Tietze, Lutz F.

“…Aldosterone 1 is a mineralocorticoid, it has great influence on the blood pressure and its glucuronide is an important marker for the detection of several…”
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Metal-free Halogen(I) Catalysts for Oxidation of (Aryl)(heteroaryl)-methanes to Ketones or Esters : Selectivity Control by Halogen Bond by Guha, Somraj, Sekar, Govindasamy

“…Use of metal-free halogen(I) catalysts has been described for the selective oxidation of (aryl)(heteroaryl)methanes (C(sp3)-H) to ketones (C(sp2)=O) or esters…”
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival by Hoi, David M., Junker, Sabryna, Junk, Lukas, Schwechel, Kristin, Fischel, Katharina, Podlesainski, David, Hawkins, Paige M.E., van Geelen, Lasse, Kaschani, Farnusch, Leodolter, Julia, Morreale, Francesca Ester, Kleine, Stefan, Guha, Somraj, Rumpel, Klaus, Schmiedel, Volker M., Weinstabl, Harald, Meinhart, Anton, Payne, Richard J., Kaiser, Markus, Hartl, Markus, Boehmelt, Guido, Kazmaier, Uli, Kalscheuer, Rainer, Clausen, Tim

“…The ClpC1:ClpP1P2 protease is a core component of the proteostasis system in mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp…”
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Cover Feature: Role of Lewis‐Base‐Coordinated Halogen(I) Intermediates in Organic Synthesis: The Journey from Unstable Intermediates to Versatile Reagents (Eur. J. Org. Chem. 37/2017) by Guha, Somraj, Kazi, Imran, Nandy, Anuradha, Sekar, Govindasamy

“…The Cover Feature shows rays of the rising sun illuminating sea water, a natural source of halogen, and the evolution of halogen(I) species in organic…”
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