Search Results - "Guha, Ipsita"

RGS5–TGFβ–Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth by Dasgupta, Shayani, Ghosh, Tithi, Dhar, Jesmita, Bhuniya, Avishek, Nandi, Partha, Das, Arnab, Saha, Akata, Das, Juhina, Guha, Ipsita, Banerjee, Saptak, Chakravarti, Mohona, Dasgupta, Partha Sarathi, Alam, Neyaz, Chakrabarti, Jayanta, Majumdar, Subrata, Chakrabarti, Pinak, Storkus, Walter J., Baral, Rathindranath, Bose, Anamika

“…Regulator-of-G-protein-signaling-5 (RGS5), a pro-apoptotic/anti-proliferative protein, is a signature molecule of tumor-associated pericytes, highly expressed…”
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c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity by Dar, Asif A., Kim, Dale D., Gordon, Scott M., Klinzing, Kathleen, Rosen, Siera, Guha, Ipsita, Porter, Nadia, Ortega, Yohaniz, Forsyth, Katherine S., Roof, Jennifer, Fazelinia, Hossein, Spruce, Lynn A., Eisenlohr, Laurence C., Behrens, Edward M., Oliver, Paula M.

“…During infection, virus-specific CD8 + T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and…”
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The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study by Das, Juhina, Bera, Saurav, Ganguly, Nilanjan, Guha, Ipsita, Ghosh Halder, Tithi, Bhuniya, Avishek, Nandi, Partha, Chakravarti, Mohona, Dhar, Sukanya, Sarkar, Anirban, Das, Tapasi, Banerjee, Saptak, Ghose, Sandip, Bose, Anamika, Baral, Rathindranath

“…Murine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma…”
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Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB by Ganguly, Nilanjan, Das, Tapasi, Bhuniya, Avishek, Guha, Ipsita, Chakravarti, Mohona, Dhar, Sukanya, Sarkar, Anirban, Bera, Saurav, Dhar, Jesmita, Dasgupta, Shayani, Saha, Akata, Ghosh, Tithi, Das, Juhina, Sk, Ugir Hossain, Banerjee, Saptak, Laskar, Subrata, Bose, Anamika, Baral, Rathindranath

“…A water-soluble ingredient of mature leaves of the tropical mahogany 'Neem' (Azadirachta indica), was identified as glycoprotein, thus being named as 'Neem…”
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Neem leaf glycoprotein prevents post-surgical sarcoma recurrence in Swiss mice by differentially regulating cytotoxic T and myeloid-derived suppressor cells by Sarkar, Madhurima, Ghosh, Sarbari, Bhuniya, Avishek, Ghosh, Tithi, Guha, Ipsita, Barik, Subhasis, Biswas, Jaydip, Bose, Anamika, Baral, Rathindranath

“…Post-surgical tumor recurrence is a common problem in cancer treatment. In the present study, the role of neem leaf glycoprotein (NLGP), a novel…”
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Neem Leaf Glycoprotein Restrains VEGF Production by Direct Modulation of HIF1α-Linked Upstream and Downstream Cascades by Saha, Akata, Nandi, Partha, Dasgupta, Shayani, Bhuniya, Avishek, Ganguly, Nilanjan, Ghosh, Tithi, Guha, Ipsita, Banerjee, Saptak, Baral, Rathindranath, Bose, Anamika

“…Neem Leaf Glycoprotein (NLGP) is a natural immunomodulator, have shown sustained tumor growth restriction as well as angiogenic normalization chiefly by…”
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NLGP counterbalances the immunosuppressive effect of tumor-associated mesenchymal stem cells to restore effector T cell functions by Ghosh, Tithi, Nandi, Partha, Ganguly, Nilanjan, Guha, Ipsita, Bhuniya, Avishek, Ghosh, Sarbari, Sarkar, Anirban, Saha, Akata, Dasgupta, Shayani, Baral, Rathindranath, Bose, Anamika

“…A dynamic interaction between tumor cells and its surrounding stroma promotes the initiation, progression, metastasis, and chemoresistance of solid tumors…”
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Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling by Guha, Ipsita, Bhuniya, Avishek, Shukla, Divanshu, Patidar, Ashok, Nandi, Partha, Saha, Akata, Dasgupta, Shayani, Ganguly, Nilanjan, Ghosh, Sweta, Nair, Arathi, Majumdar, Subrata, Saha, Bhaskar, Storkus, Walter J, Baral, Rathindranath, Bose, Anamika

“…Tumor progression in the host leads to severe impairment of intrathymic T-cell differentiation/maturation, leading to the paralysis of cellular anti-tumor…”
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NLGP Attenuates Murine Melanoma and Carcinoma Metastasis by Modulating Cytotoxic CD8 + T Cells by Bhuniya, Avishek, Guha, Ipsita, Ganguly, Nilanjan, Saha, Akata, Dasgupta, Shayani, Nandi, Partha, Das, Arnab, Ghosh, Sarbari, Ghosh, Tithi, Haque, Enamul, Banerjee, Saptak, Bose, Anamika, Baral, Rathindranath

“…Neem leaf glycoprotein (NLGP), a natural immunomodulator, attenuates murine carcinoma and melanoma metastasis, independent of primary tumor growth and…”
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AKT1low Quiescent Cancer Cells Promote Solid Tumor Growth by Alves, Cleidson P., Dey-Guha, Ipsita, Kabraji, Sheheryar, Yeh, Albert C., Talele, Nilesh P., Solé, Xavier, Chowdhury, Joeeta, Mino-Kenudson, Mari, Loda, Massimo, Sgroi, Dennis, Borresen-Dale, Anne-Lise, Russnes, Hege G., Ross, Kenneth N., Ramaswamy, Sridhar

“…Abstract Human tumor growth depends on rapidly dividing cancer cells driving population expansion. Even advanced tumors, however, contain slowly proliferating…”
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Asymmetric cancer cell division regulated by AKT by Dey-Guha, Ipsita, Wolfer, Anita, Yeh, Albert C., Albeck, John G., Darp, Revati, Leon, Eduardo, Wulfkuhle, Julia, Petricoin, Emanuel F., Wittner, Ben S., Ramaswamy, Sridhar

“…Human tumors often contain slowly proliferating cancer cells that resist treatment, but we do not know precisely how these cells arise. We show that rapidly…”
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A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells by Lee, Sooncheol, Micalizzi, Douglas, Truesdell, Samuel S, Bukhari, Syed I A, Boukhali, Myriam, Lombardi-Story, Jennifer, Kato, Yasutaka, Choo, Min-Kyung, Dey-Guha, Ipsita, Ji, Fei, Nicholson, Benjamin T, Myers, David T, Lee, Dongjun, Mazzola, Maria A, Raheja, Radhika, Langenbucher, Adam, Haradhvala, Nicholas J, Lawrence, Michael S, Gandhi, Roopali, Tiedje, Christopher, Diaz-Muñoz, Manuel D, Sweetser, David A, Sadreyev, Ruslan, Sykes, David, Haas, Wilhelm, Haber, Daniel A, Maheswaran, Shyamala, Vasudevan, Shobha

“…Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse…”
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AKT Inhibition Promotes Nonautonomous Cancer Cell Survival by Salony, Solé, Xavier, Alves, Cleidson P, Dey-Guha, Ipsita, Ritsma, Laila, Boukhali, Myriam, Lee, Ju H, Chowdhury, Joeeta, Ross, Kenneth N, Haas, Wilhelm, Vasudevan, Shobha, Ramaswamy, Sridhar

“…Small molecule inhibitors of AKT (v-akt murine thymoma viral oncogene homolog) signaling are being evaluated in patients with various cancer types, but have so…”
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Integrin β1 activation induces an anti-melanoma host response by Ritsma, Laila, Dey-Guha, Ipsita, Talele, Nilesh, Sole, Xavier, Salony, Chowdhury, Joeeta, Ross, Kenneth N, Ramaswamy, Sridhar

“…TGF-β is a cytokine thought to function as a tumor promoter in advanced malignancies. In this setting, TGF-β increases cancer cell proliferation, survival, and…”
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Tyrosine phosphorylation controls nuclear localization and transcriptional activity of Ssdp1 in mammalian cells by Dey-Guha, Ipsita, Malik, Nasir, Lesourne, Renaud, Love, Paul E., Westphal, Heiner

“…The LIM‐HD proteins interact with different cofactors, including Ssdp1 to regulate development in a diverse range of species. The single stranded DNA binding…”
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Role of ldb1 in adult intestinal homeostasis by Dey-Guha, Ipsita, Mukhopadhyay, Mahua, Phillips, Matthew, Westphal, Heiner

“…Ldb1 is an essential co-regulator of transcription in embryonic development. It acts in conjunction with nuclear LIM-homeodomain and LIM-only proteins to…”
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The role of Cul5 in Group 2 innate lymphoid cells (ILC2s) by Guha, Ipsita, Dar, Asif Amin, Kumar, Binod, Porter, Nadia, Oliver, Paula M

“…Abstract Over the past few years we have witnessed a change in the study of allergic inflammation from a view that holds T helper type 2 cells at the centre of…”
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Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers by Parikh, Aparna R., Leshchiner, Ignaty, Elagina, Liudmila, Goyal, Lipika, Levovitz, Chaya, Siravegna, Giulia, Livitz, Dimitri, Rhrissorrakrai, Kahn, Martin, Elizabeth E., Van Seventer, Emily E., Hanna, Megan, Slowik, Kara, Utro, Filippo, Pinto, Christopher J., Wong, Alicia, Danysh, Brian P., de la Cruz, Ferran Fece, Fetter, Isobel J., Nadres, Brandon, Shahzade, Heather A., Allen, Jill N., Blaszkowsky, Lawrence S., Clark, Jeffrey W., Giantonio, Bruce, Murphy, Janet E., Nipp, Ryan D., Roeland, Eric, Ryan, David P., Weekes, Colin D., Kwak, Eunice L., Faris, Jason E., Wo, Jennifer Y., Aguet, François, Dey-Guha, Ipsita, Hazar-Rethinam, Mehlika, Dias-Santagata, Dora, Ting, David T., Zhu, Andrew X., Hong, Theodore S., Golub, Todd R., Iafrate, A. John, Adalsteinsson, Viktor A., Bardelli, Alberto, Parida, Laxmi, Juric, Dejan, Getz, Gad, Corcoran, Ryan B.

“…During cancer therapy, tumor heterogeneity can drive the evolution of multiple tumor subclones harboring unique resistance mechanisms in an individual patient…”
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The E3 Ubiquitin ligase Cul4b is required for CD8+ T cell-mediated antiviral immunity by Dar, Asif Amin, Gordon, Scott, Klinzing, Kathleen, Dale, Kim, Porter, Nadia, Guha, Ipsita, Behrens, Edward M, Oliver, Paula M

“…Abstract CD8+ T cells play crucial roles in cellular immune mechanisms that clear invading viruses and prevent reinfection. Virus specific CD8+ T cells expand…”
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CRL4b Inhibition Ameliorates Experimental Autoimmune Encephalomyelitis Progression by Dar, Asif A, Ortega, Yohaniz, Aktas, Sera, Wu, Kenneth, Guha, Ipsita, Porter, Nadia, Rosen, Siera, DeVita, Robert J, Pan, Zhen-Qiang, Oliver, Paula M

“…Multiple sclerosis, and its murine model experimental autoimmune encephalomyelitis (EAE), is a neurodegenerative autoimmune disease of the CNS characterized by…”
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