Search Results - "Guha, Chandan"

Hepatic Radiation Toxicity: Avoidance and Amelioration by Guha, Chandan, MD, PhD, Kavanagh, Brian D., MD, MPH

“…The refinement of radiation therapy and radioembolization techniques has led to a resurgent interest in radiation-induced liver disease (RILD). The awareness…”
Get full text

Tumor Cells Surviving Exposure to Proton or Photon Radiation Share a Common Immunogenic Modulation Signature, Rendering Them More Sensitive to T Cell–Mediated Killing by Gameiro, Sofia R., PhD, Malamas, Anthony S., PhD, Bernstein, Michael B., MD, Tsang, Kwong Y., PhD, Vassantachart, April, BS, Sahoo, Narayan, PhD, Tailor, Ramesh, PhD, Pidikiti, Rajesh, PhD, Guha, Chandan P., MBBS, BS, PhD, Hahn, Stephen M., MD, Krishnan, Sunil, MD, Hodge, James W., PhD, MBA

“…Purpose To provide the foundation for combining immunotherapy to induce tumor antigen–specific T cells with proton radiation therapy to exploit the activity of…”
Get full text

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury by Saha, Subhrajit, Aranda, Evelyn, Hayakawa, Yoku, Bhanja, Payel, Atay, Safinur, Brodin, N Patrik, Li, Jiufeng, Asfaha, Samuel, Liu, Laibin, Tailor, Yagnesh, Zhang, Jinghang, Godwin, Andrew K., Tome, Wolfgang A., Wang, Timothy C., Guha, Chandan, Pollard, Jeffrey W.

“…WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and…”
Get full text

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Demaria, Sandra, Guha, Chandan, Schoenfeld, Jonathan, Morris, Zachary, Monjazeb, Arta, Sikora, Andrew, Crittenden, Marka, Shiao, Stephen, Khleif, Samir, Gupta, Seema, Formenti, Silvia Chiara, Vikram, Bhadrasain, Coleman, C Norman, Ahmed, Mansoor M

“…Recent evidence indicates that ionizing radiation can enhance immune responses to tumors. Advances in radiation delivery techniques allow hypofractionated…”
Get full text

Enhancing Immunogenicity in Metastatic Melanoma: Adjuvant Therapies to Promote the Anti-Tumor Immune Response by Pelka, Sandra, Guha, Chandan

“…Advanced melanoma is an aggressive form of skin cancer characterized by low survival rates. Less than 50% of advanced melanoma patients respond to current…”
Get full text

The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies by Kumar, Vivek, Vashishta, Mohit, Kong, Lin, Wu, Xiaodong, Lu, Jiade J, Guha, Chandan, Dwarakanath, B S

“…Resistance to therapy is the major hurdle in the current cancer management. Cancer cells often rewire their cellular process to alternate mechanisms to resist…”
Get full text

Radiation Therapy Noncompliance and Clinical Outcomes in an Urban Academic Cancer Center by Ohri, Nitin, MD, Rapkin, Bruce D., PhD, Guha, Chandan, MD, PhD, Kalnicki, Shalom, MD, Garg, Madhur, MD

“…Purpose To examine associations between radiation therapy (RT) noncompliance and clinical outcomes. Methods and Materials We reviewed all patients who…”
Get full text

An in situ autologous tumor vaccination with combined radiation therapy and TLR9 agonist therapy by Zhang, Huagang, Liu, Laibin, Yu, Dong, Kandimalla, Ekambar R, Sun, Hui Bin, Agrawal, Sudhir, Guha, Chandan

“…Recent studies have shown that a new generation of synthetic agonist of Toll-like receptor (TLR) 9 consisting a 3'-3'-attached structure and a dCp7-deaza-dG…”
Get full text

In vitro evaluation of antioxidant and antibacterial properties of supercritical CO2 extracted essential oil from clove bud (Syzygium aromaticum) by Das, Misti, Roy, Sutapa, Guha, Chandan, Saha, Asit Kumar, Singh, Mukesh

“…The antioxidant and antimicrobial activity of the essential oil extracted from Syzygium aromaticum was investigated. Extraction of oil was carried out…”
Get full text

In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma by Singh, Mohit Pratap, Sethuraman, Sri Nandhini, Ritchey, Jerry, Fiering, Steven, Guha, Chandan, Malayer, Jerry, Ranjan, Ashish

“…The success of melanoma immunotherapy is dependent on the presence of activated and functional T-cells in tumors. The objective of this study was to…”
Get full text

MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa by Tadesse, Selamawit, Corner, Georgia, Dhima, Elena, Houston, Michele, Guha, Chandan, Augenlicht, Leonard, Velcich, Anna

“…The mucus layer in the intestine affects several aspects of intestinal biology, encompassing physical, chemical protection, immunomodulation and growth, thus…”
Get full text

Mitigation of total body irradiation-induced mortality and hematopoietic injury of mice by a thrombopoietin mimetic (JNJ-26366821) by Kumar, Vidya P., Holmes-Hampton, Gregory P., Biswas, Shukla, Stone, Sasha, Sharma, Neel Kamal, Hritzo, Bernadette, Guilfoyle, Mary, Eichenbaum, Gary, Guha, Chandan, Ghosh, Sanchita P.

“…The threat of a nuclear attack has increased in recent years highlighting the benefit of developing additional therapies for the treatment of victims suffering…”
Get full text

Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice by Saha, Subhrajit, Bhanja, Payel, Kabarriti, Rafi, Liu, Laibin, Alfieri, Alan A, Guha, Chandan

“…Nuclear accidents and terrorism presents a serious threat for mass casualty. While bone-marrow transplantation might mitigate hematopoietic syndrome, currently…”
Get full text

Using CT-guided stereotactic prostate radiation therapy (CT-SPRT) to assess sustained murine prostate ablation by Zahalka, Ali H., Brodin, N. Patrik, Maryanovich, Maria, Wang, Xizhe, Watts, Kara L., Pinho, Sandra, Guha, Chandan, Frenette, Paul S.

“…The prostate is a hormone-responsive organ where testicular androgens drive the proliferation and survival of prostatic cells, ensuring the development and…”
Get full text

Intestinal Microbiota-Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury by Ó Broin, Pilib, PhD, Vaitheesvaran, Bhavapriya, PhD, Saha, Subhrajit, PhD, Hartil, Kirsten, PhD, Chen, Emily I., PhD, Goldman, Devorah, PhD, Fleming, William Harv, MD, PhD, Kurland, Irwin J., MD, PhD, Guha, Chandan, MBBS, PhD, Golden, Aaron, PhD

“…Purpose Assessing whole-body radiation injury and absorbed dose is essential for remediation efforts following accidental or deliberate exposure in medical,…”
Get full text

Identification of adult hepatic progenitor cells capable of repopulating injured rat liver by Yovchev, Mladen I., Grozdanov, Petar N., Zhou, Hongchao, Racherla, Harini, Guha, Chandan, Dabeva, Mariana D.

“…Oval cells appear and expand in the liver when hepatocyte proliferation is compromised. Many different markers have been attributed to these cells, but their…”
Get full text

Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury by Acharya, Sanket S, Fendler, Wojciech, Watson, Jacqueline, Hamilton, Abigail, Pan, Yunfeng, Gaudiano, Emily, Moskwa, Patryk, Bhanja, Payel, Saha, Subhrajit, Guha, Chandan, Parmar, Kalindi, Chowdhury, Dipanjan

“…Accidental radiation exposure is a threat to human health that necessitates effective clinical planning and diagnosis. Minimally invasive biomarkers that can…”
Get more information

Host conditioning and rejection monitoring in hepatocyte transplantation in humans by Soltys, Kyle A, Setoyama, Kentaro, Tafaleng, Edgar N, Soto Gutiérrez, Alejandro, Fong, Jason, Fukumitsu, Ken, Nishikawa, Taichiro, Nagaya, Masaki, Sada, Rachel, Haberman, Kimberly, Gramignoli, Roberto, Dorko, Kenneth, Tahan, Veysel, Dreyzin, Alexandra, Baskin, Kevin, Crowley, John J, Quader, Mubina A, Deutsch, Melvin, Ashokkumar, Chethan, Shneider, Benjamin L, Squires, Robert H, Ranganathan, Sarangarajan, Reyes-Mugica, Miguel, Dobrowolski, Steven F, Mazariegos, George, Elango, Rajavel, Stolz, Donna B, Strom, Stephen C, Vockley, Gerard, Roy-Chowdhury, Jayanta, Cascalho, Marilia, Guha, Chandan, Sindhi, Rakesh, Platt, Jeffrey L, Fox, Ira J

“…Graphical abstract…”
Get full text

Continuous Activity Monitoring during Concurrent Chemoradiotherapy by Ohri, Nitin, M.D, Kabarriti, Rafi, M.D, Bodner, William R., M.D, Mehta, Keyur J., M.D, Shankar, Viswanathan, Dr.P.H, Halmos, Balazs, M.D, Haigentz, Missak, M.D, Rapkin, Bruce, Ph.D, Guha, Chandan, M.B.B.S., Ph.D, Kalnicki, Shalom, M.D, Garg, Madhur, M.D

“…Abstract Background Wearable activity monitors are widely available and marketed as fitness trackers. We performed a prospective trial testing the feasibility…”
Get full text

PEGylated thrombopoietin mimetic, JNJ‑26366821 a novel prophylactic radiation countermeasure for acute radiation injury by Holmes-Hampton, Gregory P., Kumar, Vidya P., Biswas, Shukla, Stone, Sasha, Sharma, Neel K., Legesse, Betre, Vercellino, Justin, Guha, Chandan, Eichenbaum, Gary, Ghosh, Sanchita P.

“…Thrombopoietin (TPO) is the primary regulator of platelet generation and a stimulator of multilineage hematopoietic recovery following exposure to total body…”
Get full text