Search Results - "Guggisberg, Ann M"

Isoprenoid biosynthesis in Plasmodium falciparum by Guggisberg, Ann M, Amthor, Rachel E, Odom, Audrey R

“…Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies…”
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GAPDH mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites by Jezewski, Andrew J, Guggisberg, Ann M, Hodge, Dana M, Ghebremichael, Naomi, John, Gavin Nicholas, McLellan, Lisa K, Odom John, Audrey Ragan

“…Efforts to control the global malaria health crisis are undermined by antimalarial resistance. Identifying mechanisms of resistance will uncover the underlying…”
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Sweet Talk: Regulating Glucose Metabolism in Toxoplasma by Guggisberg, Ann M., Odom, Audrey R.

“…Toxoplasma gondii, the causative agent of toxoplasmosis, is an intracellular parasite that demonstrates a remarkable ability to adapt to nutrient availability…”
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Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites by Guggisberg, Ann M, Frasse, Philip M, Jezewski, Andrew J, Kafai, Natasha M, Gandhi, Aakash Y, Erlinger, Samuel J, Odom John, Audrey R

“…In the malaria parasite , synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits…”
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A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites by Guggisberg, Ann M., Park, Jooyoung, Edwards, Rachel L., Kelly, Megan L., Hodge, Dana M., Tolia, Niraj H., Odom, Audrey R.

“…Isoprenoid biosynthesis through the methylerythritol phosphate (MEP) pathway generates commercially important products and is a target for antimicrobial drug…”
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Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1 by Park, Jooyoung, Guggisberg, Ann M., Odom, Audrey R., Tolia, Niraj H.

“…Haloacid dehalogenases (HADs) are a large enzyme superfamily of more than 500 000 members with roles in numerous metabolic pathways. Plasmodium falciparum HAD1…”
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Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin by Guggisberg, Ann M., Sundararaman, Sesh A., Lanaspa, Miguel, Moraleda, Cinta, González, Raquel, Mayor, Alfredo, Cisteró, Pau, Hutchinson, David, Kremsner, Peter G., Hahn, Beatrice H., Bassat, Quique, Odom, Audrey R.

“…Novel antimalarial therapies are needed in the face of emerging resistance to artemisinin combination therapies. A previous study found a high cure rate in…”
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Regulation of the Dynamic Chromatin Architecture of the Epidermal Differentiation Complex Is Mediated by a c-Jun/AP-1-Modulated Enhancer by Oh, Inez Y., Albea, Danielle M., Goodwin, Zane A., Quiggle, Ashley M., Baker, Breeana P., Guggisberg, Ann M., Geahlen, Jessica H., Kroner, Grace M., de Guzman Strong, Cristina

“…The epidermal differentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant expression is a hallmark feature of…”
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Natural History of Plasmodium odocoilei Malaria Infection in Farmed White-Tailed Deer by Guggisberg, Ann M, Sayler, Katherine A, Wisely, Samantha M, Odom John, Audrey R

“…White-tailed deer ( ), an ecologically and economically important species, are the most widely distributed large animals in North America. A recent study…”
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Natural History of italic toggle="yes">Plasmodium odocoilei /italic> Malaria Infection in Farmed White-Tailed Deer by Ann M. Guggisberg, Katherine A. Sayler, Samantha M. Wisely, Audrey R. Odom John

“…ABSTRACT White-tailed deer (Odocoileus virginianus), an ecologically and economically important species, are the most widely distributed large animals in North…”
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Discovery and characterization of a novel class of metabolic regulators in the malaria parasite Plasmodium falciparum by Guggisberg, Ann M

“…The malaria parasite, Plasmodium falciparum, infects hundreds of millions of people per year and causes hundreds of thousands of deaths. Within the host red…”
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