Search Results - "Guggilapu, Sravanthi Devi"
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Synthesis and apoptosis inducing studies of triazole linked 3-benzylidene isatin derivatives
Published in European journal of medicinal chemistry (29-11-2016)“…In our venture towards the development of effective cytotoxic agents, a panel of triazole linked 3-benzylidene isatin hybrids were synthesized and…”
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Synthesis and biological evaluation of oxindole linked indolyl-pyrimidine derivatives as potential cytotoxic agents
Published in Bioorganic & medicinal chemistry letters (01-07-2016)“…[Display omitted] In our endeavor towards the development of effective cytotoxic agents, a series of oxindole linked indolyl-pyrimidine derivatives were…”
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3
New (3-(1 H -benzo[ d ]imidazol-2-yl))/(3-(3 H -imidazo[4,5- b ]pyridin-2-yl))-(1 H -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors
Published in MedChemComm (01-02-2018)“…A series of new (3-(1 -benzo[ ]imidazol-2-yl))/(3-(3 -imidazo[4,5- ]pyridin-2-yl))-(1 -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates were synthesized…”
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4
An efficient one-pot oxidative esterification of aldehydes to carboxylic esters using B(C6F5)3–TBHP
Published in Tetrahedron letters (11-02-2015)“…[Display omitted] A simple and efficient protocol for oxidative esterification of diverse aldehydes with alcohols was accomplished with tert-butyl…”
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5
Synthesis of thiazole linked indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors
Published in European journal of medicinal chemistry (29-09-2017)“…A series of thiazole linked indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against DU145 (prostate),…”
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Novel chromenyl-based 2-iminothiazolidin-4-one derivatives as tubulin polymerization inhibitors: Design, synthesis, biological evaluation and molecular modelling studies
Published in Journal of molecular structure (05-02-2021)“…Here-in, we present molecular design, chemical synthesis and evaluation of novel chromenyl-based 2-iminothiazolidin-4-one derivatives as tubulin polymerization…”
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Telomerase Inhibition and Human Telomeric G‑Quadruplex DNA Stabilization by a β‑Carboline–Benzimidazole Derivative at Low Concentrations
Published in Biochemistry (Easton) (22-08-2017)“…Guanine rich regions in DNA, which can form highly stable secondary structures, namely, G-quadruplex or G4 DNA structures, affect DNA replication and…”
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Aldehyde-Promoted One-Pot Regiospecific Synthesis of Acrylamides Using an in Situ Generated Molybdenum Tetracarbonyl Amine [Mo(CO)4(amine)2] Complex
Published in Organic letters (18-09-2015)“…A novel complex system generated in situ from Mo(CO)6 and an amine is described for the regiospecific aminocarbonylation of various terminal alkynes. The…”
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9
B(C6F5)3 as versatile catalyst: an efficient and mild protocol for the one-pot synthesis of functionalized piperidines and 2-substituted benzimidazole derivatives
Published in Tetrahedron letters (02-12-2015)“…[Display omitted] An efficient, mild and environmentally benign protocol has been developed for the diastereoselective one-pot synthesis of functionalized…”
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10
Discovery of certain benzyl/phenethyl thiazolidinone-indole hybrids as potential anti-proliferative agents: Synthesis, molecular modeling and tubulin polymerization inhibition study
Published in Bioorganic chemistry (01-11-2019)“…[Display omitted] •The new benzyl/phenethyl thiazolidinone-indole hybrids were synthesized.•Synthesized compounds displayed prominent antiproliferative…”
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11
Design and synthesis of 1,2,3-triazole–etodolac hybrids as potent anticancer molecules
Published in RSC advances (01-01-2017)“…A series of novel 1,2,3-triazole–etodolac hybrids ( 6a–l ) were designed and synthesized as potent anti-cancer molecules. The synthesis strongly relied on…”
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12
An efficient one-pot oxidative esterification of aldehydes to carboxylic esters using B(C sub(6)F sub(5)) sub(3)-TBHP
Published in Tetrahedron letters (11-02-2015)“…A simple and efficient protocol for oxidative esterification of diverse aldehydes with alcohols was accomplished with tert-butyl hydroperoxide and 1 mol % of…”
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13
Synthesis of C 5 -tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors
Published in European journal of medicinal chemistry (10-03-2017)“…A series of C -tethered Indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against DU145 (prostate), PC-3…”
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14
Synthesis of C5-tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors
Published in European journal of medicinal chemistry (10-03-2017)“…A series of C5-tethered Indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against DU145 (prostate), PC-3…”
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15
New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7md00450h
Published 21-02-2018“…A series of new (3-(1 H -benzo[ d ]imidazol-2-yl))/(3-(3 H -imidazo[4,5- b ]pyridin-2-yl))-(1 H -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates…”
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16
New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00450h
Published in MedChemComm (12-12-2017)“…A series of new benzimidazole-indole linked phenstatin conjugates 4–6(a–i) were synthesized and evaluated for their anticancer activity. A series of new (3-(1…”
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17
Design and Synthesis of New Etodolac‐Pyridazinones as Potent Anticancer Agents Using Pb(OAc)4 to Assist N‐N Bond Formation
Published in ChemistrySelect (Weinheim) (15-05-2018)“…Pb(OAc)4 to assist N−N bond formation via dehydrogenative cyclization of hydrazide‐hydrazones to generate the pyridazinones as bioactive molecules have been…”
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Design and synthesis of 1,2,3-triazole-etodolac hybrids as potent anticancer moleculesElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ra28525b
Published 02-05-2017“…A series of novel 1,2,3-triazole-etodolac hybrids ( 6a-l ) were designed and synthesized as potent anti-cancer molecules. The synthesis strongly relied on…”
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