Effect of supposed radioprotectors on oxidation-reduction of vitamin E in the tissues of irradiated rats

In experiments with mature Wistar male rats under irradiation by dose of 5 Gy the effect of emoxypine, citomedine and echinacea purpurea on the content of liposoluble vitamin A, carotene, vitamin E and its metabolites (quinone and oxidized tocopherol) in blood plasma, spleen, liver and testes was st...

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Bibliographic Details
Published in:	Radiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 33; no. 5; p. 653
Main Authors:	Paranich, A V, Pocherniaeva, V F, Dubinskaia, G M, Mishchenko, V P, Mironova, N G, Gugalo, V P, Nazarets, V V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1993
Subjects:	Animals Benzoquinones - metabolism Carotenoids - metabolism Echinacea Liver - metabolism Liver - radiation effects Male Oxidation-Reduction Peptides - pharmacokinetics Peptides - pharmacology Picolines - pharmacokinetics Picolines - pharmacology Plant Extracts - pharmacokinetics Plant Extracts - pharmacology Plants, Medicinal Radiation Dosage Radiation Tolerance Radiation-Protective Agents - pharmacokinetics Radiation-Protective Agents - pharmacology Rats Rats, Wistar Spleen - metabolism Spleen - radiation effects Testis - metabolism Testis - radiation effects Vitamin A - metabolism Vitamin E - metabolism
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Summary:	In experiments with mature Wistar male rats under irradiation by dose of 5 Gy the effect of emoxypine, citomedine and echinacea purpurea on the content of liposoluble vitamin A, carotene, vitamin E and its metabolites (quinone and oxidized tocopherol) in blood plasma, spleen, liver and testes was studied. It was shown the drugs under study mobilized the internal reserves of these vitamins and promoted effective functioning of vitamin E redox system. Mechanisms of their action are different. The drugs might be used as radioprotectors, but they exhaust the reserves of the liposoluble vitamins. Therefore they should be used in a combination with vitamin preparations.
ISSN:	0869-8031