Search Results - "Guga, P"

Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells by Benimetskaya, L, Miller, P, Benimetsky, S, Maciaszek, A, Guga, P, Beaucage, S L, Wilk, A, Grajkowski, A, Halperin, A L, Stein, C A

“…Isis 3521 and G3139 are 20- and 18-mer phosphorothioate oligonucleotides, respectively, targeted to the protein kinase C (PKC)-alpha and bcl-2 mRNAs. Treatment…”
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Effect of P-Chirality of Internucleotide Bonds on B−Z Conversion of Stereodefined Self-Complementary Phosphorothioate Oligonucleotides of the [PS]-d(CG)4 and [PS]-d(GC)4 Series by Boczkowska, Małgorzata, Guga, Piotr, Karwowski, Bolesław, Maciaszek, Anna

“…Diastereomerically pure, partially modified (in selected positions) or fully modified phosphorothioate oligomers of the [PS]-d(CG)4 and [PS]-d(GC)4 series were…”
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Comparison of the cleavage profiles of oligonucleotide duplexes with or without phosphorothioate linkages by using a chemical nuclease probe by Chworos, A, Arnaud, P, Zakrzewska, K, Guga, P, Pratviel, G, Stec, W, Meunier, B

“…A manganese porphyrin complex, Mn-TMPyP, associated with KHSO(5) is a chemical nuclease able to selectively recognize the minor groove of three consecutive AT…”
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The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro by Tchorzewski, H, Zeman, K, Kantorski, J, Paleolog, E, Kahan, M, Feldmann, M, Kwinkowski, M, Guga, P, Szymanska, B, Parniewski, P, Wilk, A, Jarosz, J

“…TUMOUR necrosis factor-ex (TNF-α) has been implicated as an important inflammatory mediator. In vitro, TNF-α is reported to activate human polymorphonuclear…”
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The immunoregulatory granulocyte factor (GF). III. Characteristics of target cells for GF by Majewska, E, Baj, Z, Guga, P, Zeman, K, Tchórzewski, H

“…Granulocyte factor (GF) is a substance secreted selectively from the specific granules of granulocytes in the first minutes of adherence or phagocytosis. GF…”
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Stereodefined Phosphorothioate Analogues of DNA:  Relative Thermodynamic Stability of the Model PS-DNA/DNA and PS-DNA/RNA Complexes by Boczkowska, Małgorzata, Guga, Piotr, Stec, Wojciech J

“…Thermodynamic data regarding the influence of P-chirality on stability of duplexes formed between phosphorothioate DNA oligonucleotides (of either…”
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Restoration of catalytic functions in Cre recombinase mutants by electrostatic compensation between active site and DNA substrate by Kachroo, Aashiq H, Ma, Chien-Hui, Rowley, Paul A, Maciaszek, Anna D, Guga, Piotr, Jayaram, Makkuni

“…Two conserved catalytic arginines, Arg-173 and Arg-292, of the tyrosine site-specific recombinase Cre are essential for the transesterification steps of strand…”
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Oxathiaphospholane Approach to the Synthesis of Oligodeoxyribonucleotides Containing Stereodefined Internucleotide Phosphoroselenoate Function by Guga, Piotr, Maciaszek, Anna, Stec, Wojciech J

“…5‘-O-DMT-deoxyribonucleoside-3‘-O-(2-selena-4,4-pentamethylene-1,3,2-oxathiaphospholane) monomers, derivatives of dA, dC, dG, and T, can be resolved into pure…”
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Synthesis and expression in E. coli of the gene for human tumor necrosis factor (h alpha TNF) by Kłysik, J, Konarzewska-Zglińska, A, Gałazka, G, Uznański, B, Okruszek, A, Guga, P, Wilk, A, Koziołkiewicz, M, Tchórzewski, H, Zembala, M

“…A gene coding for human tumor necrosis factor (h alpha TNF) has been assembled by ligating short oligodeoxyribonucleotides and cloning into plasmid vectors…”
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Deoxyribonucleoside 3‘-O-(2-Thio- and 2-Oxo-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane)s:  Monomers for Stereocontrolled Synthesis of Oligo(deoxyribonucleoside phosphorothioate)s and Chimeric PS/PO Oligonucleotides by Stec, Wojciech J, Karwowski, Bolesław, Boczkowska, Małgorzata, Guga, Piotr, Koziołkiewicz, Maria, Sochacki, Marek, Wieczorek, Michał W, Błaszczyk, Jarosław

“…New monomers, 5‘-O-DMT-deoxyribonucleoside 3‘-O-(2-thio-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane)s, were prepared and used for the stereocontrolled…”
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Effect of Phosphorothioate Chirality on i-Motif Structure and Stability by Kanaori, Kenji, Sakamoto, Shunji, Yoshida, Hiroyuki, Guga, Pitor, Stec, Wojtech, Tajima, Kunihiko, Makino, Keisuke

“…The P-chiral stereo-defined phosphorothioate groups have been introduced into all of the four internucleotide positions of d(TPS1CPS2CPS3CPS4C) (PSn =…”
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Diastereomers of thymidine 3'-O-(methanephosphonothioate): synthesis, absolute configuration and reaction with 3'-methoxyacetylthymidine under conditions of triester approach to oligonucleotide synthesis by Niewiarowski, W, Leśnikowski, Z J, Wilk, A, Guga, P, Okruszek, A, Uznański, B, Stec, W

“…Diastereomers of the title compound were obtained and absolute configuration was assigned by means of stereochemical correlation. Their reaction with…”
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Diastereomers of Nucleoside 3'-O-(2-Thio-1,3,2-oxathia(selena)phospholanes): Building Blocks for Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s by Stec, Wojciech J, Grajkowski, Andrzej, Kobylanska, Anna, Karwowski, Boleslaw, Koziolkiewicz, Maria, Misiura, Konrad, Okruszek, Andrzej, Wilk, Andrzej, Guga, Piotr, Boczkowska, Malgorzata

“…Diastereomerically pure 5'-O-DMT-nucleoside 3'-O-(2-thio-1,3,2-oxathiaphospholanes) and their oxathiaphospholane ring-substituted analogues were used for the…”
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Assembling gold nanoparticles in solution using phosphorothioate DNA as structural interconnects by Kumar, Ashavani, Phadtare, Sumant, Pasricha, Renu, Guga, Piotr, Ganesh, Krishna N., Sastry, Murali

“…The ordered arrangement of nanoparticles in one, two and three-dimensional structures is a problem of current interest. While assembly of nanoparticles from…”
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Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope by Guga, Piotr, Domański, Krzysztof, Stec, Wojciech J.

“…Diastereomerically pure and isotopically labeled 5′‐O‐DMT‐nucleoside‐3′‐O‐(2‐thio‐ and ‐oxo‐4,4‐“spiro”‐pentamethylene‐1,3,2‐[18O]oxathiaphospholane)s were…”
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Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model by Inagawa, Takubumi, Nakashima, Hideki, Karwowski, Boleslaw, Guga, Piotr, Stec, Wojciech J., Takeuchi, Hiroaki, Takaku, Hiroshi

“…Oligo(nucleoside phosphorothioate)s (S-ODNs), if prepared by conventional methods, consist of a mixture of diastereomers by virtue of the asymmetry of the…”
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Retention of Configuration in the Action of Human Plasma 3‘-Exonuclease on Oligo(deoxynucleoside phosphorothioate). A New Method for Assignment of Absolute Configuration at Phosphorus in Isotopomeric Deoxyadenosine 5‘-O-[18O]Phosphorothioate by Koziołkiewicz, Maria, Owczarek, Alina, Wójcik, Marzena, Domański, Krzysztof, Guga, Piotr, Stec, Wojciech J

“…A new method of analysis has allowed the exonucleolytic cleavage by human 3‘-exonuclease to be determined. Hydrolysis by human plasma 3‘-exonuclease proceeds…”
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Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition? by Tonelli, Marco, Ulyanov, Nikolai B., Billeci, Todd M., Karwowski, Boleslaw, Guga, Piotr, Stec, Wojciech J., James, Thomas L.

“…Chemically modified DNA oligonucleotides have been crucial to the development of antisense therapeutics. High-resolution structural studies of pharmaceutically…”
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Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent by Benimetskaya, Lyuba, Tonkinson, John L., Koziolkiewicz, Maria, Karwowski, Boleslaw, Guga, Piotr, Zeltser, Ross, Stec, Wojciech, Stein, C.A.

“…Antisense oligodeoxynucleotides can selectively inhibit the expression of individual genes and thus have potential applications in anticancer and antiviral…”
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STUDIES IN ANTIMALARIALS: SOME R-AND R'- DISUBSTITUTED GUANIDINES by Gupta, P. R., Guha, P. C.

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