Search Results - "Guettouche, Toumy"

Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study by Mestdagh, Pieter, Hartmann, Nicole, Baeriswyl, Lukas, Andreasen, Ditte, Bernard, Nathalie, Chen, Caifu, Cheo, David, D'Andrade, Petula, DeMayo, Mike, Dennis, Lucas, Derveaux, Stefaan, Feng, Yun, Fulmer-Smentek, Stephanie, Gerstmayer, Bernhard, Gouffon, Julia, Grimley, Chris, Lader, Eric, Lee, Kathy Y, Luo, Shujun, Mouritzen, Peter, Narayanan, Aishwarya, Patel, Sunali, Peiffer, Sabine, Rüberg, Silvia, Schroth, Gary, Schuster, Dave, Shaffer, Jonathan M, Shelton, Elliot J, Silveria, Scott, Ulmanella, Umberto, Veeramachaneni, Vamsi, Staedtler, Frank, Peters, Thomas, Guettouche, Toumy, Wong, Linda, Vandesompele, Jo

“…12 microRNA expression profiling platforms are compared for their reproducibility, sensitivity, accuracy and specificity, and the strengths and weaknesses of…”
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Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense by Harashima, Ai, Guettouche, Toumy, Barber, Glen N

“…Here, we describe a new mechanism of host defense that involves the nuclear factors associated with dsRNA (NFAR1 [90 kDa] and NFAR2 [110 kDa]), which…”
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Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress by Guettouche, Toumy, Boellmann, Frank, Lane, William S, Voellmy, Richard

“…Heat shock factor (HSF/HSF1) not only is the transcription factor primarily responsible for the transcriptional response of cells to physical and chemical…”
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Comparison of three targeted enrichment strategies on the SOLiD sequencing platform by Hedges, Dale J, Guettouche, Toumy, Yang, Shan, Bademci, Guney, Diaz, Ashley, Andersen, Ashley, Hulme, William F, Linker, Sara, Mehta, Arpit, Edwards, Yvonne J K, Beecham, Gary W, Martin, Eden R, Pericak-Vance, Margaret A, Zuchner, Stephan, Vance, Jeffery M, Gilbert, John R

“…Despite the ever-increasing throughput and steadily decreasing cost of next generation sequencing (NGS), whole genome sequencing of humans is still not a…”
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Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19 by Dannebaum, Richard, Suwalski, Phillip, Asgharian, Hosseinali, Du Zhipei, Gracie, Lin, Hai, Weiner, January, Holtgrewe, Manuel, Thibeault, Charlotte, Müller, Melina, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Blüher, Anja, Siemann, Sandra, Telman, Dilduz, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Skurk, Carsten, Poller, Wolfgang, Sander, Leif E, Beule, Dieter, Kurth, Florian, Guettouche, Toumy, Landmesser, Ulf, Berka, Jan, Luong, Khai, Rubelt, Florian, Heidecker, Bettina

“…Disease progression of subjects with coronavirus disease 2019 (COVID-19) varies dramatically. Understanding the various types of immune response to SARS-CoV-2…”
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Evidence for a Mechanism of Repression of Heat Shock Factor 1 Transcriptional Activity by a Multichaperone Complex by Guo, Yongle, Guettouche, Toumy, Fenna, Mary, Boellmann, Frank, Pratt, William B., Toft, David O., Smith, David F., Voellmy, Richard

“…In the absence of stress, human heat shock factor 1 (hHSF1) is in its unactivated form. hHSF1 polypeptide is in a dynamic heterocomplex with Hsp90 and is…”
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DAXX Interacts with Heat Shock Factor 1 during Stress Activation and Enhances Its Transcriptional Activity by Boellmann, Frank, Guettouche, Toumy, Guo, Yongle, Fenna, Mary, Mnayer, Laila, Voellmy, Richard, Roeder, Robert G.

“…DAXX, a modulator of apoptosis and a repressor of basal transcription, was identified in a two-hybrid screen as a protein capable of interacting with a…”
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Genome-wide mRNA and miRNA expression data analysis to screen for markers involved in sarcomagenesis in human chondrosarcoma cell lines by Issac, Biju, Galoian, Karina, Guettouche, Toumy, Navarro, Loida, Temple, H. Thomas

“…Genes and miRNAs involved in sarcomagenesis related pathways are unknown and therefore signaling events leading to mesenchymal cell transformation to sarcoma…”
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Nucleobase analogs for degenerate hybridization devised through conformational pairing analysis by Abraham, Michelle L, Albalos, Maria, Guettouche, Toumy, Friesenhahn, Michel J, Battersby, Thomas R

“…A conformational pairing analysis was used to devise nucleobase analogs capable of forming nonselective and energetically favorable base pairs opposite either…”
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MALE SEX, HLA-C04:01 AND COVID-19: A RISKY CONSTELLATION by Suwalski, Phillip, Patriki, Dimitri, Quedenau, Claudia, Borodina, Tatiana, Beer, Juerg H., Wiggli, Benedikt, Guettouche, Toumy, Landmesser, Ulf, Heidecker, Bettina

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Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples by Northcott, Paul A., Shih, David J. H., Remke, Marc, Cho, Yoon-Jae, Kool, Marcel, Hawkins, Cynthia, Eberhart, Charles G., Dubuc, Adrian, Guettouche, Toumy, Cardentey, Yoslayma, Bouffet, Eric, Pomeroy, Scott L., Marra, Marco, Malkin, David, Rutka, James T., Korshunov, Andrey, Pfister, Stefan, Taylor, Michael D.

“…The diagnosis of medulloblastoma likely encompasses several distinct entities, with recent evidence for the existence of at least four unique molecular…”
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An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection by Shaked, Abraham, Chang, Bao‐Li, Barnes, Michael R., Sayre, Peter, Li, Yun R., Asare, Smita, DesMarais, Michele, Holmes, Michael V., Guettouche, Toumy, Keating, Brendan J.

“…The ability to noninvasively diagnose acute cellular rejection (ACR) with high specificity and sensitivity would significantly advance personalized liver…”
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Improved coverage and accuracy with strand-conserving sequence enrichment by Guettouche, Toumy, Zuchner, Stephan

“…Targeted next-generation sequencing is becoming a common tool in the molecular diagnostic laboratory. However, currently available methods to enrich for…”
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Improving Specificity for Ovarian Cancer Screening Using a Novel Extracellular Vesicle–Based Blood Test by Winn-Deen, Emily S., Bortolin, Laura T., Gusenleitner, Daniel, Biette, Kelly M., Copeland, Karen, Gentry-Maharaj, Aleksandra, Apostolidou, Sophia, Couvillon, Anthony D., Salem, Daniel P., Banerjee, Sanchari, Grosha, Jonian, Zabroski, Ibukunoluwapo O., Sedlak, Christopher R., Byrne, Delaney M., Hamzeh, Bilal F., King, MacKenzie S., Cuoco, Lauren T., Duff, Peter A., Manning, Brendan J., Hawkins, Troy B., Mattoon, Dawn, Guettouche, Toumy, Skates, Steven J., Jamieson, Amy, McAlpine, Jessica N., Huntsman, David, Menon, Usha

“…The low incidence of ovarian cancer (OC) dictates that any screening strategy needs to be both highly sensitive and highly specific. This study explored the…”
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Increased risk of severe clinical course of COVID-19 in carriers of HLA-C04:01 by Weiner, January, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H., Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arjun Arkal, Rao, Fragiadakis, Gabriela K., Mick, Eran, COMET, Consortium, Calfee, Carolyn S., Erle, David J., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Langelier, Charles R., Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, Heidecker, Bettina

“…Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics…”
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Design and Implementation of the International Genetics and Translational Research in Transplantation Network

“…BACKGROUNDGenetic association studies of transplantation outcomes have been hampered by small samples and highly complex multifactorial phenotypes, hindering…”
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Colocalization of Cancer-Associated Biomarkers on Single Extracellular Vesicles for Early Detection of Cancer by Salem, Daniel P., Bortolin, Laura T., Gusenleitner, Dan, Grosha, Jonian, Zabroski, Ibukunoluwapo O., Biette, Kelly M., Banerjee, Sanchari, Sedlak, Christopher R., Byrne, Delaney M., Hamzeh, Bilal F., King, MacKenzie S., Cuoco, Lauren T., Santos-Heiman, Timothy, Barcaskey, Gabrielle N., Yang, Katherine S., Duff, Peter A., Winn-Deen, Emily S., Guettouche, Toumy, Mattoon, Dawn R., Huang, Eric K., Schekman, Randy W., Couvillon, Anthony D., Sedlak, Joseph C.

“…Detection of cancer early, when it is most treatable, remains a significant challenge because of the lack of diagnostic methods sufficiently sensitive to…”
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Chronic hepatitis B and viral genotype : the clinical significance of determining HBV genotypes by GUETTOUCHE, Toumy, HNATYSZYN, H. James

“…The global health challenge posed by the hepatitis B virus (HBV) centres around the widespread distribution and the serious complications as a result of…”
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Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma by Galoian, Karina A., Guettouche, Toumy, Issac, Biju, Qureshi, Amir, Temple, H. T.

“…Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to chemotherapy or radiation; therefore,…”
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Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1 by Zou, Jiangying, Guo, Yongle, Guettouche, Toumy, Smith, David F, Voellmy, Richard

“…Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp…”
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