Search Results - "Guethlein, Lisbeth"

Genetics of Natural Killer Cells in Human Health, Disease, and Survival by Parham, Peter, Guethlein, Lisbeth A

“…Natural killer (NK) cells have vital functions in human immunity and reproduction. In the innate and adaptive immune responses to infection, particularly by…”
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Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles by Robinson, James, Guethlein, Lisbeth A, Cereb, Nezih, Yang, Soo Young, Norman, Paul J, Marsh, Steven G E, Parham, Peter

“…HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage lymphocyte receptors. Recently, clinical application of…”
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Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus by Pyo, Chul-Woo, Guethlein, Lisbeth A, Vu, Quyen, Wang, Ruihan, Abi-Rached, Laurent, Norman, Paul J, Marsh, Steven G E, Miller, Jeffrey S, Parham, Peter, Geraghty, Daniel E

“…The fast evolving human KIR gene family encodes variable lymphocyte receptors specific for polymorphic HLA class I determinants. Nucleotide sequences for 24…”
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Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry by Horowitz, Amir, Strauss-Albee, Dara M, Leipold, Michael, Kubo, Jessica, Nemat-Gorgani, Neda, Dogan, Ozge C, Dekker, Cornelia L, Mackey, Sally, Maecker, Holden, Swan, Gary E, Davis, Mark M, Norman, Paul J, Guethlein, Lisbeth A, Desai, Manisha, Parham, Peter, Blish, Catherine A

“…Natural killer (NK) cells play critical roles in immune defense and reproduction, yet remain the most poorly understood major lymphocyte population. Because…”
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Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules by Parham, Peter, Norman, Paul J., Abi-Rached, Laurent, Guethlein, Lisbeth A.

“…In placental mammals, natural killer (NK) cells are a population of lymphocytes that make unique contributions to immune defence and reproduction, functions…”
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Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells by Djaoud, Zakia, Guethlein, Lisbeth A, Horowitz, Amir, Azzi, Tarik, Nemat-Gorgani, Neda, Olive, Daniel, Nadal, David, Norman, Paul J, Münz, Christian, Parham, Peter

“…Most humans become infected with Epstein-Barr virus (EBV), which then persists for life. Infrequently, EBV infection causes infectious mononucleosis (IM) or…”
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CD56-negative NK cells: Frequency in peripheral blood, expansion during HIV-1 infection, functional capacity, and KIR expression by Cocker, Alexander T. H., Liu, Fuguo, Djaoud, Zakia, Guethlein, Lisbeth A., Parham, Peter

“…Human NK cells are usually defined as CD3 - CD56 + lymphocytes. However, a CD56 - CD16 + (CD56neg) lymphocyte population that displays NK-associated markers…”
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Co-evolution of MHC class I and variable NK cell receptors in placental mammals by Guethlein, Lisbeth A., Norman, Paul J., Hilton, Hugo G., Parham, Peter

“…Summary Shaping natural killer (NK) cell functions in human immunity and reproduction are diverse killer cell immunoglobulin‐like receptors (KIRs) that…”
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Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes by Hilton, Hugo G, Guethlein, Lisbeth A, Goyos, Ana, Nemat-Gorgani, Neda, Bushnell, David A, Norman, Paul J, Parham, Peter

“…The human killer cell Ig-like receptor (KIR) locus comprises two groups of KIR haplotypes, termed A and B. These are present in all human populations but with…”
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Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans by Norman, Paul J, Hollenbach, Jill A, Nemat-Gorgani, Neda, Guethlein, Lisbeth A, Hilton, Hugo G, Pando, Marcelo J, Koram, Kwadwo A, Riley, Eleanor M, Abi-Rached, Laurent, Parham, Peter

“…Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors (KIR) control natural killer cell (NK) functions in immunity and…”
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Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia by Cooley, Sarah, Weisdorf, Daniel J., Guethlein, Lisbeth A., Klein, John P., Wang, Tao, Le, Chap T., Marsh, Steven G.E., Geraghty, Daniel, Spellman, Stephen, Haagenson, Michael D., Ladner, Martha, Trachtenberg, Elizabeth, Parham, Peter, Miller, Jeffrey S.

“…Killer-cell immunoglobulin-like receptor (KIR) genes form a diverse, immunogenetic system. Group A and B KIR haplotypes have distinctive centromeric (Cen) and…”
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The CD56-CD16+ NK cell subset in chronic infections by Cocker, Alexander T H, Guethlein, Lisbeth A, Parham, Peter

“…Long-term human diseases can shape the immune system, and natural killer (NK) cells have been documented to differentiate into distinct subsets specifically…”
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IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex by Maccari, Giuseppe, Robinson, James, Ballingall, Keith, Guethlein, Lisbeth A, Grimholt, Unni, Kaufman, Jim, Ho, Chak-Sum, de Groot, Natasja G, Flicek, Paul, Bontrop, Ronald E, Hammond, John A, Marsh, Steven G E

“…The IPD-MHC Database project (http://www.ebi.ac.uk/ipd/mhc/) collects and expertly curates sequences of the major histocompatibility complex from non-human…”
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Two to Tango: Co-evolution of Hominid Natural Killer Cell Receptors and MHC by Wroblewski, Emily E, Parham, Peter, Guethlein, Lisbeth A

“…Natural killer (NK) cells have diverse roles in hominid immunity and reproduction. Modulating these functions are the interactions between major…”
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Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions by Thiel, Gerald, Rubil, Sandra, Lesch, Andrea, Guethlein, Lisbeth A., Rössler, Oliver G.

“…[Display omitted] The transient receptor potential melastatin-3 (TRPM3) channel belongs to the family of transient receptor potential (TRP) cation channels…”
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Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals by Vierra-Green, Cynthia, Roe, David, Hou, Lihua, Hurley, Carolyn Katovich, Rajalingam, Raja, Reed, Elaine, Lebedeva, Tatiana, Yu, Neng, Stewart, Mary, Noreen, Harriet, Hollenbach, Jill A, Guethlein, Lisbeth A, Wang, Tao, Spellman, Stephen, Maiers, Martin

“…The immune responses of natural killer cells are regulated, in part, by killer cell immunoglobulin-like receptors (KIR). The 16 closely-related genes in the…”
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Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells by Abi-Rached, Laurent, Moesta, Achim K, Rajalingam, Raja, Guethlein, Lisbeth A, Parham, Peter

“…Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are…”
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Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population by Hilton, Hugo G, Norman, Paul J, Nemat-Gorgani, Neda, Goyos, Ana, Hollenbach, Jill A, Henn, Brenna M, Gignoux, Christopher R, Guethlein, Lisbeth A, Parham, Peter

“…Modulating natural killer cell functions in human immunity and reproduction are diverse interactions between the killer cell immunoglobulin-like receptors…”
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Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia by Cooley, Sarah, Weisdorf, Daniel J, Guethlein, Lisbeth A, Klein, John P, Wang, Tao, Marsh, Steven G E, Spellman, Stephen, Haagenson, Michael D, Saeturn, Koy, Ladner, Martha, Trachtenberg, Elizabeth, Parham, Peter, Miller, Jeffrey S

“…Killer cell Ig-like receptors (KIRs) interact with HLA class I ligands to regulate NK cell development and function. These interactions affect the outcome of…”
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Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and gamma delta T cells by Djaoud, Zakia, Guethlein, Lisbeth A, Horowitz, Amir, Azzi, Tarik, Nemat-Gorgani, Neda, Olive, Daniel, Nadal, David, Norman, Paul J, Munz, Christian, Parham, Peter

“…Djaoud et al. show that Epstein-Barr virus infection triggers two types of human innate immune response, one mediated by the combination of NK cells and gamma…”
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