Search Results - "Guest, Ryan D."

The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity by Thistlethwaite, Fiona C., Gilham, David E., Guest, Ryan D., Rothwell, Dominic G., Pillai, Manon, Burt, Deborah J., Byatte, Andrea J., Kirillova, Natalia, Valle, Juan W., Sharma, Surinder K., Chester, Kerry A., Westwood, Nigel B., Halford, Sarah E. R., Nabarro, Stephen, Wan, Susan, Austin, Eric, Hawkins, Robert E.

“…The primary aim of this clinical trial was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5 +…”
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Clinical feasibility and treatment outcomes with nonselected autologous tumor-infiltrating lymphocyte therapy in patients with advanced cutaneous melanoma by Pillai, Manon, Jiang, Yizhou, Lorigan, Paul C, Thistlethwaite, Fiona C, Thomas, Martine, Kirillova, Natalia, Bridgeman, John S, Kueberuwa, Gray, Biswas, Sunetra, Velazquez, Peter, Chonzi, David, Guest, Ryan D, Roberts, Zachary J, Hawkins, Robert E

“…Nonselected autologous tumor-infiltrating lymphocytes (TILs) may provide advantages over other treatments for solid tumors, including checkpoint…”
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The role of extracellular spacer regions in the optimal design of chimeric immune receptors: Evaluation of four different scFvs and antigens by GUEST, Ryan D, HAWKINS, Robert E, EMBLETON, M. J, STERN, Peter L, GILHAM, David E, KIRILLOVA, Natalia, CHEADLE, Eleanor J, ARNOLD, Jennifer, O'NEILL, Allison, IRLAM, Joely, CHESTER, Kerry A, KEMSHEAD, John T, SHAW, David M

“…Human peripheral blood lymphocytes can be transduced to express antigen-dependent CD3zeta chimeric immune receptors (CIRs), which function independently of the…”
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Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial by Guest, Ryan D., Kirillova, Natalia, Mowbray, Sam, Gornall, Hannah, Rothwell, Dominic G., Cheadle, Eleanor J., Austin, Eric, Smith, Keith, Watt, Suzanne M., Kühlcke, Klaus, Westwood, Nigel, Thistlethwaite, Fiona, Hawkins, Robert E., Gilham, David E.

“…Adoptive cell therapy employing gene-modified T-cells expressing chimeric antigen receptors (CARs) has shown promising preclinical activity in a range of model…”
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177 Treatment outcomes with unselected autologous tumor infiltrating lymphocytes in patients with checkpoint inhibition–refractory advanced cutaneous melanoma by Hawkins, Robert, Jiang, Yizhou, Lorigan, Paul C, Thistlethwaite, Fiona C, Pillai, Manon, Thomas, Martine, Kirillova, Natalia, Bridgeman, John S, Kueberuwa, Gray, Guest, Ryan D, Roberts, Zachary J

“…BackgroundTumor infiltrating lymphocyte (TIL) products made from tumor digests showed a high overall response rate (ORR; 67%) and complete response (CR) rate…”
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059 Role of cryopreservation in the clinical delivery of T cell based adoptive cell therapies (ACT) by Guest, Ryan D., Rothwell, Dominic G., Kirillova, Natalia, Mowbray, Sam, Sheard, Vicky, Gibbons, Stephanie, Acton, Elizabeth, Gilham, David, Morris, G. John, Hawkins, Robert

“…The development of Adoptive Cell Therapy (ACT) based immunotherapies using either naturally-occurring or genetically engineered T cells to target tumours have…”
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Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3ζ-based chimeric immune receptors by GILHAM, David E, O'NEIL, Allison, HUGHES, Chris, GUEST, Ryan D, KIRILLOVA, Natalia, LEHANE, Margaret, HAWKINS, Robert E

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Gene therapy of patient-derived T lymphocytes to target and eradicate colorectal hepatic metastases by Sheen, Aali J, Irlam, Joely, Kirillova, Natalia, Guest, Ryan D, Sherlock, David J, Hawkins, Robert E, Gilham, David E

“…The overall aim of this study was to develop a novel treatment for colorectal cancer based on the use of gene therapy. Genetic modification of T lymphocytes…”
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Cryopreservation of T cells for adoptive T cell therapy by Sheard, Victoria, Morris, John, Guest, Ryan D., Hawkins, Robert E., Gilham, David E.

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P53 integrity in the genetically engineered mammalian cell lines AHH-1 and MCL-5 by Guest, R D, Parry, J M

“…Recently, a C to T transition mutation in exon 8 of the p53 gene has been identified in a subculture of the genetically engineered human lymphoblastoid cell…”
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Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors by Gilham, David E, O'Neil, Allison, Hughes, Chris, Guest, Ryan D, Kirillova, Natalia, Lehane, Margaret, Hawkins, Robert E

“…Antigen-specific T lymphocytes are attractive as potential anticancer agents. The generation of large numbers of antigen-specific T cells is possible through…”
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