Search Results - "Guest, P. C"

Identification of a biological signature for schizophrenia in serum by Schwarz, E, Guest, P C, Rahmoune, H, Harris, L W, Wang, L, Leweke, F M, Rothermundt, M, Bogerts, B, Koethe, D, Kranaster, L, Ohrmann, P, Suslow, T, McAllister, G, Spain, M, Barnes, A, van Beveren, N J M, Baron-Cohen, S, Steiner, J, Torrey, F E, Yolken, R H, Bahn, S

“…Biomarkers are now used in many areas of medicine but are still lacking for psychiatric conditions such as schizophrenia (SCZ). We have used a multiplex…”
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Sex-specific serum biomarker patterns in adults with Asperger's syndrome by Schwarz, E, Guest, P C, Rahmoune, H, Wang, L, Levin, Y, Ingudomnukul, E, Ruta, L, Kent, L, Spain, M, Baron-Cohen, S, Bahn, S

“…Autism spectrum conditions have been hypothesized to be an exaggeration of normal male low-empathizing and high-systemizing behaviors. We tested this…”
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Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients by Chan, M K, Tsang, T M, Harris, L W, Guest, P C, Holmes, E, Bahn, S

“…Extensive research has been conducted on post-mortem brain tissue in schizophrenia (SCZ), particularly the dorsolateral prefrontal cortex (DLPFC). However, to…”
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Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset by Chan, M K, Krebs, M-O, Cox, D, Guest, P C, Yolken, R H, Rahmoune, H, Rothermundt, M, Steiner, J, Leweke, F M, van Beveren, N J M, Niebuhr, D W, Weber, N S, Cowan, D N, Suarez-Pinilla, P, Crespo-Facorro, B, Mam-Lam-Fook, C, Bourgin, J, Wenstrup, R J, Kaldate, R R, Cooper, J D, Bahn, S

“…Recent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We…”
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System-based proteomic and metabonomic analysis of the Df(16)A+/− mouse identifies potential miR-185 targets and molecular pathway alterations by Wesseling, H, Xu, B, Want, E J, Holmes, E, Guest, P C, Karayiorgou, M, Gogos, J A, Bahn, S

“…Deletions on chromosome 22q11.2 are a strong genetic risk factor for development of schizophrenia and cognitive dysfunction. We employed shotgun liquid…”
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Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients by Herberth, M, Koethe, D, Cheng, T M K, Krzyszton, N D, Schoeffmann, S, Guest, P C, Rahmoune, H, Harris, L W, Kranaster, L, Leweke, F M, Bahn, S

“…Little is known about the biological mechanisms underpinning the pathology of schizophrenia. We have analysed the proteome of stimulated and unstimulated…”
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Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients by Schwarz, E, Guest, P C, Steiner, J, Bogerts, B, Bahn, S

“…The current inability of psychiatric medicine to objectively select the most appropriate treatment or to predict imminent relapse are major factors…”
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Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patients by Guest, P C, Wang, L, Harris, L W, Burling, K, Levin, Y, Ernst, A, Wayland, M T, Umrania, Y, Herberth, M, Koethe, D, van Beveren, J M, Rothermundt, M, McAllister, G, Leweke, F M, Steiner, J, Bahn, S

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Expression Profiling of Fibroblasts Identifies Cell Cycle Abnormalities in Schizophrenia by Wang, L, Lockstone, H. E, Guest, P. C, Levin, Y, Palotás, A, Pietsch, S, Schwarz, E, Rahmoune, H, Harris, L. W, Ma, D, Bahn, S

“…Many previous studies have attempted to gain insight into the underlying pathophysiology of schizophrenia by studying postmortem brain tissues of schizophrenia…”
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Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia by van Beveren, N J M, Schwarz, E, Noll, R, Guest, P C, Meijer, C, de Haan, L, Bahn, S

“…Molecular abnormalities in metabolic, hormonal and immune pathways are present in peripheral body fluids of a significant subgroup of schizophrenia patients…”
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Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders by Ernst, A, Sharma, A N, Elased, K M, Guest, P C, Rahmoune, H, Bahn, S

“…The db/db mouse is a widely used preclinical model in diabetes research. Recent studies have shown that these mice also display aspects of psychosis and…”
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Identification of Early Proteomic Markers for Hepatic Steatosis by Meneses-Lorente, G, Watt, A, Salim, K, Gaskell, S. J, Muniappa, Nagaraja, Lawrence, Jeffrey, Guest, P. C

“…The identification of biomarkers for disease state, drug efficacy, and toxicity is becoming increasingly important for drug discovery and development. We have…”
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Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients by Martins-de-Souza, D, Guest, P C, Harris, L W, Vanattou-Saifoudine, N, Webster, M J, Rahmoune, H, Bahn, S

“…Major depressive disorder (MDD) is a leading cause of disability worldwide and results tragically in the loss of almost one million lives in Western societies…”
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Plasma leptin correlates with anthranilic acid in schizophrenia but not in major depressive disorder by Steiner, J., Bernstein, H.-G., Guest, P.C., Summergrad, P., Oxenkrug, G.

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Proinsulin processing in the diabetic Goto-Kakizaki rat by Guest, PC, Abdel-Halim, SM, Gross, DJ, Clark, A, Poitout, V, Amaria, R, Ostenson, CG, Hutton, JC

“…The biosynthesis and processing of proinsulin was investigated in the diabetic Goto-Kakizaki (GK) rat. Immunofluorescence microscopy comparing GK and Wistar…”
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Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family by BENNETT, D. L, BAILYES, E. M, NIELSEN, E, GUEST, P. C, RUTHERFORD, N. G, ARDEN, S. D, HUTTON, J. C

“…Enzymological studies have implicated two Ca(2+)-dependent endopeptidases in the conversion of proinsulin to insulin; a type 1 activity which cleaves on the…”
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Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells by OZANNE, S. E, GUEST, P. C, HUTTON, J. C, HALES, C. N

“…Sulphonylureas stimulate insulin secretion by binding to a receptor in the pancreatic beta-cell plasma membrane resulting in inhibition of ATP-sensitive K+…”
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The post-translational processing of chromogranin A in the pancreatic islet : involvement of the eukaryote subtilisin PC2 by ARDEN, S. D, RUTHERFORD, N. G, GUEST, P. C, CURRY, W. J, BAILYES, E. M, JOHNSTON, C. F, HUTTON, J. C

“…The post-translational processing of chromogranin A (CGA) and the nature of the enzyme(s) involved were investigated in rat pancreatic islet and insulinoma…”
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A PC12 variant lacking regulated secretory organelles : Aberrant protein targeting and evidence for a factor inhibiting neuroendocrine gene expression by PANCE, A, MORGAN, K, GUEST, P. C, BOWERS, K, DEAN, G. E, CUTLER, D. F, JACKSON, A. P

“…A variant of the PC12 pheochromocytoma cell line (termed A35C) has been isolated that lacks regulated secretory organelles and several constituent proteins…”
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Insulin secretory granule biogenesis : co-ordinate regulation of the biosynthesis of the majority of constituent proteins by GUEST, P. C, BAILYES, E. M, RUTHERFORD, N. G, HUTTON, J. C

“…Two-dimensional gel-electrophoretic analysis combined with fluorography and densitometric quantification was used to examine the effects of glucose on the…”
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