Search Results - "Guerrini, Matteo M"

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation by Danks, Lynett, Komatsu, Noriko, Guerrini, Matteo M, Sawa, Shinichiro, Armaka, Marietta, Kollias, George, Nakashima, Tomoki, Takayanagi, Hiroshi

“…RANKL is mainly expressed by synovial fibroblasts and T cells within the joints of rheumatoid arthritis patients. The relative importance of RANKL expression…”
Get more information

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System by Guerrini, Matteo M., Okamoto, Kazuo, Komatsu, Noriko, Sawa, Shinichiro, Danks, Lynett, Penninger, Josef M., Nakashima, Tomoki, Takayanagi, Hiroshi

“…The central nervous system (CNS) is an immunologically privileged site protected from uncontrolled access of T cells by the blood-brain barrier (BBB), which is…”
Get full text

Infantile Malignant, Autosomal Recessive Osteopetrosis: The Rich and The Poor by Villa, Anna, Guerrini, Matteo M., Cassani, Barbara, Pangrazio, Alessandra, Sobacchi, Cristina

“…Human recessive osteopetrosis (ARO) represents a group of diseases in which, due to a defect in osteoclasts, bone resorption is prevented. The deficit could…”
Get full text

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL by Frattini, Annalisa, Sobacchi, Cristina, Guerrini, Matteo M, Abinun, Mario, Pangrazio, Alessandra, Susani, Lucia, Bredius, Robbert, Mancini, Grazia, Cant, Andrew, Bishop, Nick, Grabowski, Peter, Del Fattore, Andrea, Messina, Chiara, Errigo, Gabriella, Coxon, Fraser P, Scott, Debbie I, Teti, Anna, Rogers, Michael J, Vezzoni, Paolo, Villa, Anna, Helfrich, Miep H

“…Autosomal recessive osteopetrosis is usually associated with normal or elevated numbers of nonfunctional osteoclasts. Here we report mutations in the gene…”
Get full text

Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging by Sugiyama, Eiji, Guerrini, Matteo M., Honda, Kurara, Hattori, Yuko, Abe, Manabu, Källback, Patrik, Andrén, Per E., Tanaka, Kenji F., Setou, Mitsutoshi, Fagarasan, Sidonia, Suematsu, Makoto, Sugiura, Yuki

“…Monoamine neurotransmitters are released by specialized neurons regulating behavioral, motor, and cognitive functions. Although the localization of…”
Get full text

The immune system, bone and RANKL by Guerrini, Matteo M., Takayanagi, Hiroshi

“…•Bone and immune systems regulate each other and share many regulatory molecules.•RANKL is expressed on mesenchymal cells of the bone and activated T and B…”
Get full text

Microbiota — an amplifier of autoimmunity by Vogelzang, Alexis, Guerrini, Matteo M, Minato, Nagahiro, Fagarasan, Sidonia

“…•Commensal dysbiosis is associated with autoimmune diseases.•The gut microbial ecosystem is shaped by the host through the immune system.•The gut microbiota…”
Get full text

A Hen in the Wolf Den: A Pathobiont Tale by Guerrini, Matteo M., Vogelzang, Alexis, Fagarasan, Sidonia

“…Disruption of the gut microbiota is thought to contribute to disease onset in individuals with a genetic predisposition to autoimmunity. In a recent issue of…”
Get full text

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior by Miyajima, Michio, Zhang, Baihao, Sugiura, Yuki, Sonomura, Kazuhiro, Guerrini, Matteo M, Tsutsui, Yumi, Maruya, Mikako, Vogelzang, Alexis, Chamoto, Kenji, Honda, Kurara, Hikida, Takatoshi, Ito, Satomi, Qin, Hongyan, Sanuki, Rikako, Suzuki, Keiichiro, Furukawa, Takahisa, Ishihama, Yasushi, Matsuda, Fumihiko, Suematsu, Makoto, Honjo, Tasuku, Fagarasan, Sidonia

“…Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan…”
Get full text

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A ( RANK) Mutations by Guerrini, Matteo M., Sobacchi, Cristina, Cassani, Barbara, Abinun, Mario, Kilic, Sara S., Pangrazio, Alessandra, Moratto, Daniele, Mazzolari, Evelina, Clayton-Smith, Jill, Orchard, Paul, Coxon, Fraser P., Helfrich, Miep H., Crockett, Julie C., Mellis, David, Vellodi, Ashok, Tezcan, Ilhan, Notarangelo, Luigi D., Rogers, Michael J., Vezzoni, Paolo, Villa, Anna, Frattini, Annalisa

“…Autosomal-Recessive Osteopetrosis (ARO) comprises a heterogeneous group of bone diseases for which mutations in five genes are known as causative. Most ARO are…”
Get full text

Osteopetrosis rescue upon RANKL administration to Rankl−/− mice: A new therapy for human RANKL-dependent ARO by Lo Iacono, Nadia, Blair, Harry C, Poliani, Pietro L, Marrella, Veronica, Ficara, Francesca, Cassani, Barbara, Facchetti, Fabio, Fontana, Elena, Guerrini, Matteo M, Traggiai, Elisabetta, Schena, Francesca, Paulis, Marianna, Mantero, Stefano, Inforzato, Antonio, Valaperta, Serenella, Pangrazio, Alessandra, Crisafulli, Laura, Maina, Virginia, Kostenuik, Paul, Vezzoni, Paolo, Villa, Anna, Sobacchi, Cristina

“…In the last decades the molecular basis of monogenic diseases has been largely unraveled, although their treatment has often remained unsatisfactory. Autosomal…”
Get full text

RANK-dependent autosomal recessive osteopetrosis: Characterization of five new cases with novel mutations by Pangrazio, Alessandra, Cassani, Barbara, Guerrini, Matteo M, Crockett, Julie C, Marrella, Veronica, Zammataro, Luca, Strina, Dario, Schulz, Ansgar, Schlack, Claire, Kornak, Uwe, Mellis, David J, Duthie, Angela, Helfrich, Miep H, Durandy, Anne, Moshous, Despina, Vellodi, Ashok, Chiesa, Robert, Veys, Paul, Lo Iacono, Nadia, Vezzoni, Paolo, Fischer, Alain, Villa, Anna, Sobacchi, Cristina

“…Autosomal recessive osteopetrosis (ARO) is a genetically heterogeneous disorder attributed to reduced bone resorption by osteoclasts. Most human AROs are…”
Get full text

Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)–deficient mice and corrects their immune and metabolic defects by Mortellaro, Alessandra, Hernandez, Raisa Jofra, Guerrini, Matteo M., Carlucci, Filippo, Tabucchi, Antonella, Ponzoni, Maurilio, Sanvito, Francesca, Doglioni, Claudio, Serio, Clelia Di, Biasco, Luca, Follenzi, Antonia, Naldini, Luigi, Bordignon, Claudio, Roncarolo, Maria Grazia, Aiuti, Alessandro

“…Adenosine deaminase (ADA) deficiency is caused by a purine metabolic dysfunction, leading to severe combined immunodeficiency (SCID) and multiple organ damage…”
Get full text