Antifungal Saponins from the Maya Medicinal Plant Cestrum schlechtendahlii G. Don (Solanaceae)

Bioassay‐guided fractionation of the crude extract (80% EtOH) of the leaves of Cestrum schlechtendahlii, a plant used by Q'eqchi' Maya healers for treatment of athlete's foot, resulted in the isolation and identification of two spirostanol saponins (1 and 2). Structure elucidation by...

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Bibliographic Details
Published in:	Phytotherapy research Vol. 30; no. 3; pp. 439 - 446
Main Authors:	Ta, Chieu Anh Kim, Guerrero‐Analco, J. Antonio, Roberts, Elizabeth, Liu, Rui, Mogg, Christopher D, Saleem, Ammar, Otárola‐Rojas, Marco, Poveda, Luis, Sanchez‐Vindas, Pablo, Cal, Victor, Caal, Federico, Subramaniam, Rajagopal, Smith, Myron L, Arnason, John T
Format:	Journal Article
Language:	English
Published:	England Heyden & Son 01-03-2016 Blackwell Publishing Ltd Wiley Subscription Services, Inc
Subjects:	antifungal Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology antifungal properties Candida albicans Candida albicans - drug effects Cestrum Cestrum - chemistry Cestrum schlechtendahlii Cryptococcus neoformans Cryptococcus neoformans - drug effects ethanol Ethnic Groups fractionation Fungi - drug effects Fusarium - drug effects Fusarium graminearum growth retardation Humans leaves Magnetic Resonance Spectroscopy medicinal plants Medicine, Traditional Microbial Sensitivity Tests minimum inhibitory concentration Molecular Structure nuclear magnetic resonance spectroscopy Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plants, Medicinal Q'eqchi' Maya Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects saponin saponins Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Solanaceae Spirostans - chemistry Spirostans - isolation & purification Spirostans - pharmacology traditional medicine antifungal Q'eqchi' Maya Solanaceae Cestrum schlechtendahlii saponin traditional medicine
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Summary:	Bioassay‐guided fractionation of the crude extract (80% EtOH) of the leaves of Cestrum schlechtendahlii, a plant used by Q'eqchi' Maya healers for treatment of athlete's foot, resulted in the isolation and identification of two spirostanol saponins (1 and 2). Structure elucidation by MS, 1D‐NMR, and 2D‐NMR spectroscopic methods identified them to be the known saponin (25R)‐1β,2α‐dihydroxy‐5α‐spirostan‐3‐β‐yl‐O‐α‐l‐rhamnopyranosyl‐(1 → 2)‐β‐d‐galactopyranoside (1) and new saponin (25R)‐1β,2α‐dihydroxy‐5α‐spirostan‐3‐β‐yl‐O‐β‐d‐galactopyranoside (2). While 2 showed little or no antifungal activity at the highest concentration tested, 1 inhibited growth of Saccharomyces cerevisiae (minimum inhibitory concentration (MIC) of 15–25 μM), Candida albicans, Cryptococcus neoformans, and Fusarium graminearum (MIC of 132–198 μM). Copyright © 2015 John Wiley & Sons, Ltd.
Bibliography:	http://dx.doi.org/10.1002/ptr.5545 Supporting info item istex:0136A767159B994890DABB3F37C240592B991B21 ark:/67375/WNG-SDF2WT7M-9 ArticleID:PTR5545 NSERC - No. 210084-170399-2001 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.5545