Search Results - "Guerrero, Justin A"

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination by Zan, Hong, Tat, Connie, Qiu, Zhifang, Taylor, Julia R., Guerrero, Justin A., Shen, Tian, Casali, Paolo

“…Antibody class-switch DNA recombination (CSR) is initiated by AID-introduced DSBs in the switch (S) regions targeted for recombination, as effected by…”
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GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency by Guerrero, Justin A., Klysz, Dorota D., Chen, Yiyun, Malipatlolla, Meena, Lone, Jameel, Fowler, Carley, Stuani, Lucille, May, Audre, Bashti, Malek, Xu, Peng, Huang, Jing, Michael, Basil, Contrepois, Kévin, Dhingra, Shaurya, Fisher, Chris, Svensson, Katrin J., Davis, Kara L., Kasowski, Maya, Feldman, Steven A., Sotillo, Elena, Mackall, Crystal L.

“…The intensive nutrient requirements needed to sustain T cell activation and proliferation, combined with competition for nutrients within the tumor…”
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Inosine induces stemness features in CAR-T cells and enhances potency by Klysz, Dorota D, Fowler, Carley, Malipatlolla, Meena, Stuani, Lucille, Freitas, Katherine A, Chen, Yiyun, Meier, Stefanie, Daniel, Bence, Sandor, Katalin, Xu, Peng, Huang, Jing, Labanieh, Louai, Keerthi, Vimal, Leruste, Amaury, Bashti, Malek, Mata-Alcazar, Janette, Gkitsas, Nikolaos, Guerrero, Justin A, Fisher, Chris, Patel, Sunny, Asano, Kyle, Patel, Shabnum, Davis, Kara L, Satpathy, Ansuman T, Feldman, Steven A, Sotillo, Elena, Mackall, Crystal L

“…Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted CD8 CAR-T cells express CD39 and CD73, which mediate proximal steps in…”
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A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells by Tieu, Victor, Sotillo, Elena, Bjelajac, Jeremy R, Chen, Crystal, Malipatlolla, Meena, Guerrero, Justin A, Xu, Peng, Quinn, Patrick J, Fisher, Chris, Klysz, Dorota, Mackall, Crystal L, Qi, Lei S

“…CRISPR technologies have begun to revolutionize T cell therapies; however, conventional CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy,…”
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275 Inosine endows CAR T cells with features of increased stemness and anti-tumor potency by Klysz, Dorota, Fowler, Carley, Malipatlolla, Meena, Stuani, Lucille, Freitas, Katherine A, Meier, Stefanie, Daniel, Bence, Sandor, Katalin, Xu, Peng, Huang, Jing, Labanieh, Louai, Leruste, Amaury, Bashti, Malek, Mata-Alcazar, Janette, Keerthi, Vimal, Gkitsas, Nikolaos, Guerrero, Justin A, Fisher, Chris, Patel, Sunny, Asano, Kyle, Patel, Shabnum, Davis, Kara L, Satpathy, Ansuman T, Feldman, Steven A, Sotillo, Elena, Mackall, Crystal L

“…BackgroundCAR T cells have been highly effective against refractory B cell malignancies but have not demonstrated sustained antitumor effects against solid…”
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