Search Results - "Guerra, Jose Maria"
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Dynamin‐2 mutations linked to neonatal‐onset centronuclear myopathy impair exocytosis and endocytosis in adrenal chromaffin cells
Published in Journal of neurochemistry (01-09-2024)“…Dynamins are large GTPases whose primary function is not only to catalyze membrane scission during endocytosis but also to modulate other cellular processes,…”
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Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells
Published in British journal of pharmacology (01-08-2024)“…Background and Purpose ATP is highly accumulated in secretory vesicles and secreted upon exocytosis from neurons and endocrine cells. In adrenal chromaffin…”
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A centronuclear myopathy‐causing mutation in dynamin‐2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease
Published in Neuropathology and applied neurobiology (01-08-2023)“…Aims Dynamin‐2 is a large GTPase, a member of the dynamin superfamily that regulates membrane remodelling and cytoskeleton dynamics. Mutations in the dynamin‐2…”
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NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells
Published in Cells (Basel, Switzerland) (04-09-2020)“…The NOTCH family of receptors and ligands is involved in numerous cell differentiation processes, including adipogenesis. We recently showed that…”
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Non-Stationary Hydrological Regimes Due to Climate Change: The Impact of Future Precipitation in the Spillway Design of a Reservoir, Case Study: Sube y Baja Dam, in Ecuador
Published in Atmosphere (01-05-2022)“…Changes in flood loads and reservoir levels, produced by climate change (CC), represent an increasing concern for dam safety managers and downstream…”
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Dynamic capabilities in the tourist companies of the Colombian Caribbean coast: Case of Cartagena de Indias
Published in Intangible capital (01-01-2022)“…Purpose: This article aims to characterize factors of dynamic capabilities and analyze the relationship between them. The case study is particularized for the…”
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Biophysical and Lipidomic Biomarkers of Cardiac Remodeling Post-Myocardial Infarction in Humans
Published in Biomolecules (Basel, Switzerland) (22-10-2020)“…Few studies have analyzed the potential of biophysical parameters as markers of cardiac remodeling post-myocardial infarction (MI), particularly in human…”
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The association of dynamin with synaptophysin regulates quantal size and duration of exocytotic events in chromaffin cells
Published in The Journal of neuroscience (11-08-2010)“…Although synaptophysin is one of the most abundant integral proteins of synaptic vesicle membranes, its contribution to neurotransmitter release remains…”
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Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair Ca2+-Induced Exocytosis in Human Myoblasts
Published in International journal of molecular sciences (08-09-2022)“…Gain-of-function mutations of dynamin-2, a mechano-GTPase that remodels membrane and actin filaments, cause centronuclear myopathy (CNM), a congenital disease…”
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10
The Novel Gene EGFL9/Dlk2, Highly Homologous to Dlk1, Functions as a Modulator of Adipogenesis
Published in Journal of molecular biology (13-04-2007)“…The Dlk1 gene appears to function as a regulator of adipogenesis. Adult Dlk1-deficient mice are obese, but adipose tissue still develops in transgenic mice…”
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inflammatory response in the MPTP model of Parkinson's disease is mediated by brain angiotensin: relevance to progression of the disease
Published in Journal of neurochemistry (01-04-2009)“…The neurotoxin MPTP reproduces most of the biochemical and pathological hallmarks of Parkinson's disease. In addition to reactive oxygen species (ROS)…”
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12
Prognostic value of response to first-line hydroxyurea according to IPSET stratification in essential thrombocythemia
Published in Leukemia (27-09-2024)“…Hydroxyurea (HU) constitutes the first-line treatment in most patients with essential thrombocythemia (ET), but criteria for changing therapy are not clearly…”
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13
Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response
Published in Biomedicine & pharmacotherapy (01-08-2022)“…Antibodies against the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) specifically block cholesteryl ester (CE) accumulation in vascular cells. LRP1 is a…”
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Defects in G-Actin Incorporation into Filaments in Myoblasts Derived from Dysferlinopathy Patients Are Restored by Dysferlin C2 Domains
Published in International journal of molecular sciences (01-01-2020)“…Dysferlin is a transmembrane C-2 domain-containing protein involved in vesicle trafficking and membrane remodeling in skeletal muscle cells. However, the…”
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Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson’s disease
Published in AGE (01-08-2012)“…Recent studies have shown that renin–angiotensin system overactivation is involved in the aging process in several tissues as well as in longevity and…”
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16
Evolutionism and management
Published in Dimensión empresarial (01-01-2019)“…This editorial interrogates about the legitimate, the limits between the social system including individuals, its expression through culture and the economic…”
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Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells
Published in Scientific reports (04-07-2017)“…Dynamin-2 is a ubiquitously expressed GTP-ase that mediates membrane remodeling. Recent findings indicate that dynamin-2 also regulates actin dynamics…”
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Long-Term Cortical Atrophy after Excitotoxic Striatal Lesion: Effects of Intrastriatal Fetal-Striatum Grafts and Implications for Huntington Disease
Published in Journal of neuropathology and experimental neurology (01-08-2001)“…It is not currently clear whether the cortical atrophy observed in Huntington disease (HD) is entirely a direct consequence of the disease or at least…”
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NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages
Published in Scientific reports (09-09-2020)“…Macrophage activation by Toll receptors is an essential event in the development of the response against pathogens. NOTCH signaling pathway is involved in the…”
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PGE1‐induced NO reduces apoptosis by D‐galactosamine through attenuation of NF‐κB and NOS‐2 expression in rat hepatocytes
Published in Hepatology (Baltimore, Md.) (01-12-2004)“…Prostaglandin E1 (PGE1) reduces cell death in experimental and clinical liver dysfunction. We have previously shown that PGE1 preadministration protects…”
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