Search Results - "Guerra, Gustavo Petri"
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Modulation of learning and memory by natural polyamines
Published in Pharmacological research (01-10-2016)“…[Display omitted] Spermine and spermidine are natural polyamines that are produced mainly via decarboxylation of l-ornithine and the sequential transfer of…”
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Bisphenol A exposure is involved in the development of Parkinson like disease in Drosophila melanogaster
Published in Food and chemical toxicology (01-03-2020)“…The pathogenesis of Parkinson's disease has not been fully clarified yet but its cause is known to be multifactorial. One of these factors is oxidative stress…”
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Nitric oxide is involved in the memory facilitation induced by spermidine in rats
Published in Psychopharmacologia (01-06-2006)“…Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D: -aspartate receptor functions, which has been reported to facilitate memory formation…”
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Evaluation of oxidative stress indicators as toxicity parameters after chronic exposure of Drosophila melanogaster to free curcumin and curcumin-loaded nanocapsules
Published in Food and chemical toxicology (01-11-2023)“…We investigated a possible toxic effect induced by chronic exposure to free curcumin and curcumin-loaded nanocapsules in Drosophila melanogaster, enabling safe…”
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TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout
Published in Free radical biology & medicine (01-07-2014)“…Acute gout attacks produce severe joint pain and inflammation associated with monosodium urate (MSU) crystals leading to oxidative stress production. The…”
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Oral administration of lutein attenuates ethanol-induced memory deficit in rats by restoration of acetylcholinesterase activity
Published in Physiology & behavior (15-05-2019)“…The excessive consumption of alcohol affects the central nervous system, resulting in memory and learning deficits. Lutein is a carotenoid known for its…”
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Neuroprotective effect of red quinoa seeds extract on scopolamine-induced declarative memory deficits in mice: The role of acetylcholinesterase and oxidative stress
Published in Journal of functional foods (01-06-2020)“…[Display omitted] •RQ-S extract prevented memory deficit induced by SCP in mice.•RQ-S extract restored the changes in AChE activity and oxidative stress…”
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Participation of transient receptor potential vanilloid 1 in paclitaxel-induced acute visceral and peripheral nociception in rodents
Published in European journal of pharmacology (05-06-2018)“…The clinical use of paclitaxel as a chemotherapeutic agent is limited by the severe acute and chronic hypersensitivity caused when it is administered via…”
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The involvement of the TRPA1 receptor in a mouse model of sympathetically maintained neuropathic pain
Published in European journal of pharmacology (15-01-2015)“…Sympathetic fibres maintain some forms of neuropathic pain, but the underlying mechanisms are poorly understood. Therefore, this study investigated the…”
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Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol‐induced seizures
Published in Epilepsia (Copenhagen) (01-11-2011)“…Summary Purpose: Statins are selective inhibitors of 3‐hydroxyl‐3‐methyl‐glutaryl coenzyme A (HMG‐CoA) reductase, the rate‐limiting enzyme of the mevalonate…”
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Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats
Published in Neurobiology of learning and memory (01-09-2011)“…► H-89 or arcaine prevented memory improvement induced by spermidine (SPD). ► SPD facilitated PKA and CREB phosphorylation 180min, after administration. ► SPD…”
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Contribution of peripheral vanilloid receptor to the nociception induced by injection of spermine in mice
Published in Pharmacology, biochemistry and behavior (01-10-2011)“…Polyamines (putrescine, spermidine and spermine) are important endogenous regulators of ion channels, such as vanilloid (TRPV1), glutamatergic (NMDA or…”
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Time-dependent modulation of inhibitory avoidance memory by spermidine in rats
Published in Neurobiology of learning and memory (2005)“…The polyamines, spermine, spermidine, and putrescine, are a group of aliphatic amines that may act as physiological modulators of N-methyl- d-aspartate (NMDA)…”
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YK11 induces oxidative stress and mitochondrial dysfunction in hippocampus: The interplay between a selective androgen receptor modulator (SARM) and exercise
Published in The Journal of steroid biochemistry and molecular biology (01-10-2023)“…Our study investigates potential neurochemical effects of (17α,20E)− 17,20-[(1-methoxyethylidene)bis(oxy)]− 3-oxo-19-norpregna-4,20-diene-21-carboxylic acid…”
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CaMKIIα mediates spermidine-induced memory enhancement in rats: A potential involvement of PKA/CREB pathway
Published in Pharmacology, biochemistry and behavior (01-07-2024)“…Memory consolidation is associated with the regulation of protein kinases, which impact synaptic functions and promote synaptogenesis. The administration of…”
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From gains to gaps? How Selective Androgen Receptor Modulator (SARM) YK11 impact hippocampal function: In silico, in vivo, and ex vivo perspectives
Published in Chemico-biological interactions (01-05-2024)“…Selective Androgen Receptor Modulators (SARMs), particularly…”
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Bisphenol F and Bisphenol S exposure during development reduce neuronal ganglia integrity and change behavioral profile of Drosophila melanogaster larvae
Published in Behavioural brain research (29-02-2024)“…The behavior and neuronal ganglia integrity of Drosophila melanogaster larvae exposed to Bisphenol F (BPF) and Bisphenol S (BPS) (0.25, 0.5 and 1 mM) was…”
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Early exposure to trans fat causes cognitive impairment by modulating the expression of proteins associated with oxidative stress and synaptic plasticity in Drosophila melanogaster
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-05-2024)“…Evidence has shown that consuming trans fatty acids (TFA) during development leads to their incorporation into the nervous tissue, resulting in neurological…”
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Safer alternatives? Bisphenol F and Bisphenol S induce oxidative stress in Drosophila melanogaster larvae and trigger developmental damage
Published in Food and chemical toxicology (01-05-2023)“…Bisphenol F (BPF) and Bisphenol S (BPS) are safe alternatives substances? Here Drosophila melanogaster were exposed during development (larval stage) to BPF…”
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p-Coumaric acid potential in restoring neuromotor function and oxidative balance through the Parkin pathway in a Parkinson disease-like model in Drosophila melanogaster
Published in Food and chemical toxicology (01-11-2024)“…p-Coumaric acid is a significant phenolic compound known for its potent antioxidant activity. Thus, this study investigated the effects of p-coumaric acid on…”
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