Search Results - "Guerra, Fabiana Sélos"
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Benzo[ f ]indole-4,9-dione Derivatives Effectively Inhibit the Growth of Triple-Negative Breast Cancer
Published in Molecules (Basel, Switzerland) (21-07-2021)“…Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor clinical outcome, and currently no effective targeted therapies are available…”
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Synthesis of cannabidiol-based compounds as ACE2 inhibitors with potential application in the treatment of COVID-19
Published in European journal of medicinal chemistry (15-11-2023)“…Cannabis is a general name for plants of the genus Cannabis. Used as fiber, medicine, drug, for religious, therapeutic, and hedonistic purposes along the…”
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ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells
Published in Scientific reports (20-10-2017)“…Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), is an aggressive type of breast cancer and…”
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Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer
Published in Pharmaceuticals (Basel, Switzerland) (21-04-2021)“…Prostate cancer is the second most frequently diagnosed malignancy worldwide. Here, the cytotoxic and antimetastatic effects of a new HDAC6/8 inhibitor,…”
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Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2018)“…In this study, we synthesized a new congener series of N-sulphonylhydrazones designed as candidate ROCK inhibitors using the molecular hybridization of the…”
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Fasudil Action Analysis in Cell Migration of Tumour Cell Line MDA‐MB 231
Published in The FASEB journal (01-04-2017)“…Abstract only…”
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New Rock Inhibitors Action Analysis in the Cytoskeleton and Cell Migration of Tumor Cell Line MDA‐MB 231
Published in The FASEB journal (01-04-2018)“…Many patients with metastatic tumors have substantially worse survival in comparison with those patients with nonmetastatic tumors. The ability of cancer cells…”
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Membrane cholesterol depletion reduces breast tumor cell migration by a mechanism that involves non-canonical Wnt signaling and IL-10 secretion
Published in Translational medicine communications (30-08-2016)“…Background Migration and invasion are hallmarks of cancer cells that allow their dissemination to other tissues. Studying the cellular and molecular basis of…”
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