Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases

Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases

Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The se...

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Bibliographic Details
Published in:Indian journal of hematology & blood transfusion Vol. 32; no. Suppl 1; pp. 66 - 68
Main Authors: Bchir, M., Ayed, W., Neji, H. Ben, Kilani, O., Kefi, S., Zarrouk, M., Guermani, H., Hentati, S., Amouri, A., Meddeb, B.
Format: Journal Article
Language:English
Published: New Delhi Springer India 01-06-2016
Springer Nature B.V
Bombay: Indian Society of Hematology & Blood Transfusion
Subjects:
Blood Transfusion Medicine
Cancer therapies
Case studies
Chromosomes
Hematology
Human Genetics
Leukemia
Life Sciences
Medicine
Medicine & Public Health
Oncology
Short Communication
Klinefelter syndrome
Chronic myelogenous leukemia
Acute promyelocytic leukemia
Karyotype
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Summary:Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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PMCID: PMC4925523
ISSN:0971-4502
0974-0449
0974-0449
0971-4502
DOI:10.1007/s12288-015-0590-6