Search Results - "Guenther, Stephan"

Ebola virus disease by Malvy, Denis, McElroy, Anita K, de Clerck, Hilde, Günther, Stephan, van Griensven, Johan

“…Ebolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic disease in man and great apes. Four species of ebolaviruses have been…”
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Evaluating case definitions for Ebola virus disease by Ramharter, Michael, Günther, Stephan

“…Major clinical signs and symptoms of Ebola virus disease are also observed in a wide range of infectious diseases in Africa, including malaria and typhoid…”
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Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model by Oestereich, Lisa, Lüdtke, Anja, Wurr, Stephanie, Rieger, Toni, Muñoz-Fontela, César, Günther, Stephan

“…•T-705 suppressed replication of Zaire EBOV by 4log units in cell culture.•Mice lacking the type I interferon receptor (IFNAR−/−) were used as in vivo…”
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Biochemical characterization of the Lassa virus L protein by Vogel, Dominik, Rosenthal, Maria, Gogrefe, Nadja, Reindl, Sophia, Günther, Stephan

“…The L protein of arena- and bunyaviruses is structurally and functionally related to the orthomyxovirus polymerase complex. It plays a central role in the…”
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Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis by Eberhardt, Kirsten Alexandra, Mischlinger, Johannes, Jordan, Sabine, Groger, Mirjam, Günther, Stephan, Ramharter, Michael

“…•The quality of evidence for the use of ribavirin is very low, stemming largely from a single non-randomized clinical trial with historic controls and high…”
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Code exposed: Review of five open-source frameworks for modeling renewable energy systems by Candas, Soner, Muschner, Christoph, Buchholz, Stefanie, Bramstoft, Rasmus, van Ouwerkerk, Jonas, Hainsch, Karlo, Löffler, Konstantin, Günther, Stephan, Berendes, Sarah, Nguyen, Stefanie, Justin, Aparna

“…Energy system modeling is a commonly used method to provide policy recommendations and insight to transformation pathways of energy systems. However, the low…”
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X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease by Günther, Sebastian, Reinke, Patrick Y A, Fernández-García, Yaiza, Lieske, Julia, Lane, Thomas J, Ginn, Helen M, Koua, Faisal H M, Ehrt, Christiane, Ewert, Wiebke, Oberthuer, Dominik, Yefanov, Oleksandr, Meier, Susanne, Lorenzen, Kristina, Krichel, Boris, Kopicki, Janine-Denise, Gelisio, Luca, Brehm, Wolfgang, Dunkel, Ilona, Seychell, Brandon, Gieseler, Henry, Norton-Baker, Brenna, Escudero-Pérez, Beatriz, Domaracky, Martin, Saouane, Sofiane, Tolstikova, Alexandra, White, Thomas A, Hänle, Anna, Groessler, Michael, Fleckenstein, Holger, Trost, Fabian, Galchenkova, Marina, Gevorkov, Yaroslav, Li, Chufeng, Awel, Salah, Peck, Ariana, Barthelmess, Miriam, Schlünzen, Frank, Lourdu Xavier, P, Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Falke, Sven, Srinivasan, Vasundara, França, Bruno Alves, Schwinzer, Martin, Brognaro, Hévila, Rogers, Cromarte, Melo, Diogo, Zaitseva-Doyle, Joanna J, Knoska, Juraj, Peña-Murillo, Gisel E, Mashhour, Aida Rahmani, Hennicke, Vincent, Fischer, Pontus, Hakanpää, Johanna, Meyer, Jan, Gribbon, Philip, Ellinger, Bernhard, Kuzikov, Maria, Wolf, Markus, Beccari, Andrea R, Bourenkov, Gleb, von Stetten, David, Pompidor, Guillaume, Bento, Isabel, Panneerselvam, Saravanan, Karpics, Ivars, Schneider, Thomas R, Garcia-Alai, Maria Marta, Niebling, Stephan, Günther, Christian, Schmidt, Christina, Schubert, Robin, Han, Huijong, Boger, Juliane, Monteiro, Diana C F, Zhang, Linlin, Sun, Xinyuanyuan, Pletzer-Zelgert, Jonathan, Wollenhaupt, Jan, Feiler, Christian G, Weiss, Manfred S, Schulz, Eike-Christian, Mehrabi, Pedram, Karničar, Katarina, Usenik, Aleksandra, Loboda, Jure, Tidow, Henning, Chari, Ashwin, Hilgenfeld, Rolf, Uetrecht, Charlotte, Cox, Russell, Zaliani, Andrea, Beck, Tobias, Rarey, Matthias, Günther, Stephan, Turk, Dusan, Hinrichs, Winfried, Chapman, Henry N, Pearson, Arwen R

“…The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the…”
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Structure of a functional cap-binding domain in Rift Valley fever virus L protein by Gogrefe, Nadja, Reindl, Sophia, Günther, Stephan, Rosenthal, Maria

“…Rift Valley fever virus (RVFV) belongs to the family of Phenuiviridae within the order of Bunyavirales. The virus may cause fatal disease both in livestock and…”
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Lassa Fever: Epidemiology, Clinical Features, Diagnosis, Management and Prevention by Asogun, Danny A, Günther, Stephan, Akpede, George O, Ihekweazu, Chikwe, Zumla, Alimuddin

“…Lassa fever outbreaks West Africa have caused up to 10,000 deaths annually. Primary infection occurs from contact with Lassa virus-infected rodents and…”
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Emergence of Zaire Ebola Virus Disease in Guinea by Baize, Sylvain, Pannetier, Delphine, Oestereich, Lisa, Rieger, Toni, Koivogui, Lamine, Magassouba, N'Faly, Soropogui, Barrè, Sow, Mamadou Saliou, Keïta, Sakoba, De Clerck, Hilde, Tiffany, Amanda, Dominguez, Gemma, Loua, Mathieu, Traoré, Alexis, Kolié, Moussa, Malano, Emmanuel Roland, Heleze, Emmanuel, Bocquin, Anne, Mély, Stephane, Raoul, Hervé, Caro, Valérie, Cadar, Dániel, Gabriel, Martin, Pahlmann, Meike, Tappe, Dennis, Schmidt-Chanasit, Jonas, Impouma, Benido, Diallo, Abdoul Karim, Formenty, Pierre, Van Herp, Michel, Günther, Stephan

“…In March 2014, an outbreak of Ebola virus disease associated with a high fatality rate was identified in Guinea, with evidence of ongoing person-to-person…”
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Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks by Keita, Alpha Kabinet, Koundouno, Fara R., Faye, Martin, Düx, Ariane, Hinzmann, Julia, Diallo, Haby, Ayouba, Ahidjo, Le Marcis, Frederic, Soropogui, Barré, Ifono, Kékoura, Diagne, Moussa M., Sow, Mamadou S., Bore, Joseph A., Calvignac-Spencer, Sebastien, Vidal, Nicole, Camara, Jacob, Keita, Mamadou B., Renevey, Annick, Diallo, Amadou, Soumah, Abdoul K., Millimono, Saa L., Mari-Saez, Almudena, Diop, Mamadou, Doré, Ahmadou, Soumah, Fodé Y., Kourouma, Kaka, Vielle, Nathalie J., Loucoubar, Cheikh, Camara, Ibrahima, Kourouma, Karifa, Annibaldis, Giuditta, Bah, Assaïtou, Thielebein, Anke, Pahlmann, Meike, Pullan, Steven T., Carroll, Miles W., Quick, Joshua, Formenty, Pierre, Legand, Anais, Pietro, Karla, Wiley, Michael R., Tordo, Noel, Peyrefitte, Christophe, McCrone, John T., Rambaut, Andrew, Sidibé, Youssouf, Barry, Mamadou D., Kourouma, Madeleine, Saouromou, Cé D., Condé, Mamadou, Baldé, Moussa, Povogui, Moriba, Keita, Sakoba, Diakite, Mandiou, Bah, Mamadou S., Sidibe, Amadou, Diakite, Dembo, Sako, Fodé B., Traore, Fodé A., Ki-Zerbo, Georges A., Lemey, Philippe, Günther, Stephan, Kafetzopoulou, Liana E., Sall, Amadou A., Delaporte, Eric, Duraffour, Sophie, Faye, Ousmane, Leendertz, Fabian H., Peeters, Martine, Toure, Abdoulaye, Magassouba, N’. Faly

“…Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak—between 14 February and 19 June…”
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Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days by Diallo, Boubacar, Sissoko, Daouda, Loman, Nicholas J., Bah, Hadja Aïssatou, Bah, Hawa, Worrell, Mary Claire, Conde, Iya Saidou, Sacko, Ramata, Mesfin, Samuel, Loua, Angelo, Kalonda, Jacques Katomba, Erondu, Ngozi A., Dahl, Benjamin A., Handrick, Susann, Goodfellow, Ian, Meredith, Luke W., Cotten, Matthew, Jah, Umaru, Wadoum, Raoul Emeric Guetiya, Rollin, Pierre, Magassouba, N'Faly, Malvy, Denis, Anglaret, Xavier, Carroll, Miles W., Aylward, Raymond Bruce, Djingarey, Mamoudou Harouna, Diarra, Abdoulaye, Formenty, Pierre, Keïta, Sakoba, Günther, Stephan, Rambaut, Andrew, Duraffour, Sophie

“…We report on an Ebola virus disease (EVD) survivor who showed Ebola virus in seminal fluid 531 days after onset of disease. The persisting virus was sexually…”
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Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses by Holm, Tobias, Kopicki, Janine-Denise, Busch, Carola, Olschewski, Silke, Rosenthal, Maria, Uetrecht, Charlotte, Günther, Stephan, Reindl, Sophia

“…Viruses rely on many host cell processes, including the cellular transcription machinery. Segmented negative-strand RNA viruses (sNSV) in particular cannot…”
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Imported Oropouche fever to Germany in a returning traveller from Cuba by Maier, Melissa Ann, Neurohr, Eva-Maria, Barreto-Miranda, Isabel, Gabriel, Martin, Günther, Stephan, Bélard, Sabine

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Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever by Oestereich, Lisa, Rieger, Toni, Lüdtke, Anja, Ruibal, Paula, Wurr, Stephanie, Pallasch, Elisa, Bockholt, Sabrina, Krasemann, Susanne, Muñoz-Fontela, César, Günther, Stephan

“…We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus…”
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Comparing open source power system models - A case study focusing on fundamental modeling parameters for the German energy transition by van Ouwerkerk, Jonas, Hainsch, Karlo, Candas, Soner, Muschner, Christoph, Buchholz, Stefanie, Günther, Stephan, Huyskens, Hendrik, Berendes, Sarah, Löffler, Konstantin, Bußar, Christian, Tardasti, Fateme, von Köckritz, Luja, Bramstoft, Rasmus

“…Recent European and German climate targets call for a faster power system transition towards variable renewable energy sources. With the increasing importance…”
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A Case of Severe Ebola Virus Infection Complicated by Gram-Negative Septicemia by Kreuels, Benno, Wichmann, Dominic, Emmerich, Petra, Schmidt-Chanasit, Jonas, de Heer, Geraldine, Kluge, Stefan, Sow, Abdourahmane, Renné, Thomas, Günther, Stephan, Lohse, Ansgar W, Addo, Marylyn M, Schmiedel, Stefan

“…A relief worker who became infected with the Ebola virus while working in Sierra Leone during the largest recorded Ebola epidemic was evacuated to Hamburg,…”
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Zika virus infections imported to Italy: Clinical, immunological and virological findings, and public health implications by Zammarchi, Lorenzo, Stella, Giulia, Mantella, Antonia, Bartolozzi, Dario, Tappe, Dennis, Günther, Stephan, Oestereich, Lisa, Cadar, Daniel, Muñoz-Fontela, César, Bartoloni, Alessandro, Schmidt-Chanasit, Jonas

“…Highlights • First two cases of laboratory confirmed Zika virus infections imported into Italy are reported. • Sera from both patients exhibited…”
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Acute Zika virus infection after travel to Malaysian Borneo, September 2014 by Tappe, Dennis, Nachtigall, Stephan, Kapaun, Annette, Schnitzler, Paul, Günther, Stephan, Schmidt-Chanasit, Jonas

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Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin by Ter Horst, Sebastiaan, Fernandez-Garcia, Yaiza, Bassetto, Marcella, Günther, Stephan, Brancale, Andrea, Neyts, Johan, Rocha-Pereira, Joana

“…Baloxavir acid is an endonuclease inhibitor approved for use against influenza. We evaluated whether this compound also targets the endonuclease domain of…”
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