When the clock ticks wrong with COVID‐19

When the clock ticks wrong with COVID‐19

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of the coronavirus family that causes the novel coronavirus disease first diagnosed in 2019 (COVID‐19). Although many studies have been carried out in recent months to determine why the disease clinical presentations and outcom...

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Published in:Clinical and translational medicine Vol. 12; no. 11; pp. e949 - n/a
Main Authors: Papagerakis, Silvana, Said, Raed, Ketabat, Farinaz, Mahmood, Razi, Pundir, Meenakshi, Lobanova, Liubov, Guenther, Greg, Pannone, Giuseppe, Lavender, Kerry, McAlpin, Blake R., Moreau, Alain, Chen, Xiongbiao, Papagerakis, Petros
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-11-2022
Wiley
Subjects:
Animals
Asymptomatic
Biomarkers
Cardiovascular disease
circadian clock
Circadian Clocks
Circadian rhythm
Clinical medicine
Clinical outcomes
COVID-19
Diabetes
Enzymes
epigenetics
Fatalities
Fatigue
Health care
Hypertension
Immune system
Infections
Lifestyles
Melatonin
microRNAs
Mortality
oral and systemic precision health
personalized medicine
Physiology
SARS-CoV-2
SARS‐CoV‐2 infection
Severe acute respiratory syndrome coronavirus 2
Ticks
Viral infections
China
COVID-19
microRNAs
clinical outcomes
SARS-CoV-2 infection
oral and systemic precision health
circadian clock
epigenetics
personalized medicine
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of the coronavirus family that causes the novel coronavirus disease first diagnosed in 2019 (COVID‐19). Although many studies have been carried out in recent months to determine why the disease clinical presentations and outcomes can vary significantly from asymptomatic to severe or lethal, the underlying mechanisms are not fully understood. It is likely that unique individual characteristics can strongly influence the broad disease variability; thus, tailored diagnostic and therapeutic approaches are needed to improve clinical outcomes. The circadian clock is a critical regulatory mechanism orchestrating major physiological and pathological processes. It is generally accepted that more than half of the cell‐specific genes in any given organ are under circadian control. Although it is known that a specific role of the circadian clock is to coordinate the immune system's steady‐state function and response to infectious threats, the links between the circadian clock and SARS‐CoV‐2 infection are only now emerging. How inter‐individual variability of the circadian profile and its dysregulation may play a role in the differences noted in the COVID‐19‐related disease presentations, and outcome remains largely underinvestigated. This review summarizes the current evidence on the potential links between circadian clock dysregulation and SARS‐CoV‐2 infection susceptibility, disease presentation and progression, and clinical outcomes. Further research in this area may contribute towards novel circadian‐centred prognostic, diagnostic and therapeutic approaches for COVID‐19 in the era of precision health. SARS‐CoV‐2 entry happens through the oral and nasal cavities. Oral and/or nasal preexisting dysbiosis may affect COVID‐19 susceptibility, severity and outcomes. Bidirectional interactions between gut microbiota and the oral/nasal/lung microbiota may be involved in regulating the immune responses to SARS‐CoV‐2, which may involve the circadian clock
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ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.949