Search Results - "Guenther, G."

Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study by Stopeck, Alison T, Lipton, Allan, Body, Jean-Jacques, Steger, Guenther G, Tonkin, Katia, de Boer, Richard H, Lichinitser, Mikhail, Fujiwara, Yasuhiro, Yardley, Denise A, Viniegra, María, Fan, Michelle, Jiang, Qi, Dansey, Roger, Jun, Susie, Braun, Ada

“…This randomized study compared denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor κ B (RANK) ligand, with zoledronic…”
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A chromatin landmark and transcription initiation at most promoters in human cells by Guenther, Matthew G, Levine, Stuart S, Boyer, Laurie A, Jaenisch, Rudolf, Young, Richard A

“…We describe the results of a genome-wide analysis of human cells that suggests that most protein-coding genes, including most genes thought to be…”
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Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer by Tutt, Andrew N.J, Garber, Judy E, Kaufman, Bella, Viale, Giuseppe, Fumagalli, Debora, Rastogi, Priya, Gelber, Richard D, de Azambuja, Evandro, Fielding, Anitra, Balmaña, Judith, Domchek, Susan M, Gelmon, Karen A, Hollingsworth, Simon J, Korde, Larissa A, Linderholm, Barbro, Bandos, Hanna, Senkus, Elżbieta, Suga, Jennifer M, Shao, Zhimin, Pippas, Andrew W, Nowecki, Zbigniew, Huzarski, Tomasz, Ganz, Patricia A, Lucas, Peter C, Baker, Nigel, Loibl, Sibylle, McConnell, Robin, Piccart, Martine, Schmutzler, Rita, Steger, Guenther G, Costantino, Joseph P, Arahmani, Amal, Wolmark, Norman, McFadden, Eleanor, Karantza, Vassiliki, Lakhani, Sunil R, Yothers, Greg, Campbell, Christine, Geyer, Charles E

“…Among patients who had mutations in BRCA1 or BRCA2 and were at high risk for disease progression, those who were assigned to a year of olaparib adjuvant…”
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Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome by Orlando, David A., Chen, Mei Wei, Brown, Victoria E., Solanki, Snehakumari, Choi, Yoon J., Olson, Eric R., Fritz, Christian C., Bradner, James E., Guenther, Matthew G.

“…Epigenomic profiling by chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) is a prevailing methodology used to investigate…”
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Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer by MILES, David W, CHAN, Arlene, HARBECK, Nadia, STEGER, Guenther G, SCHNEEWEISS, Andreas, WARDLEY, Andrew M, CHLISTALLA, Andreas, ROMIEU, Gilles, DIRIX, Luc Y, CORTES, Javier, PIVOT, Xavier, TOMCZAK, Piotr, DELOZIER, Thierry, JOO HYUK SOHN, PROVENCHER, Louise, PUGLISI, Fabio

“…The efficacy and safety of combining bevacizumab (7.5 and 15 mg/kg) with docetaxel as first-line therapy for human epidermal growth factor receptor 2 (HER2)…”
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Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial by Cameron, David, Prof, Brown, Julia, Prof, Dent, Rebecca, MD, Jackisch, Christian, MD, Mackey, John, Prof, Pivot, Xavier, MD, Steger, Guenther G, Prof, Suter, Thomas M, Prof, Toi, Masakazu, Prof, Parmar, Mahesh, DPhil, Laeufle, Rita, MD, Im, Young-Hyuck, MD, Romieu, Gilles, MD, Harvey, Vernon, MD, Lipatov, Oleg, MD, Pienkowski, Tadeusz, MD, Cottu, Paul, MD, Chan, Arlene, Prof, Im, Seock-Ah, Prof, Hall, Peter S, PhD, Bubuteishvili-Pacaud, Lida, MD, Henschel, Volkmar, PhD, Deurloo, Regula J, PhD, Pallaud, Celine, PhD, Bell, Richard, Prof

“…Summary Background The addition of bevacizumab to chemotherapy improves progression-free survival in metastatic breast cancer and pathological complete…”
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Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling by Mullen, Alan C., Orlando, David A., Newman, Jamie J., Lovén, Jakob, Kumar, Roshan M., Bilodeau, Steve, Reddy, Jessica, Guenther, Matthew G., DeKoter, Rodney P., Young, Richard A.

“…Transforming growth factor beta (TGF-β) signaling, mediated through the transcription factors Smad2 and Smad3 (Smad2/3), directs different responses in…”
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Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer by Gnant, Michael, Fitzal, Florian, Rinnerthaler, Gabriel, Steger, Guenther G, Greil-Ressler, Sigrun, Balic, Marija, Heck, Dietmar, Jakesz, Raimund, Thaler, Josef, Egle, Daniel, Manfreda, Diether, Bjelic-Radisic, Vesna, Wieder, Ursula, Singer, Christian F, Melbinger-Zeinitzer, Elisabeth, Haslbauer, Ferdinand, Sevelda, Paul, Trapl, Harald, Wette, Viktor, Wimmer, Kerstin, Gampenrieder, Simon P, Bartsch, Rupert, Kacerovsky-Strobl, Stephanie, Suppan, Christoph, Brunner, Christine, Deutschmann, Christine, Soelkner, Lidija, Fesl, Christian, Greil, Richard

“…Postmenopausal women with hormone-receptor–positive breast cancer who had received 5 years of adjuvant endocrine therapy were randomly assigned to an…”
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Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells by Sigova, Alla A., Mullen, Alan C., Molinie, Benoit, Gupta, Sumeet, Orlando, David A., Guenther, Matthew G., Almada, Albert E., Lin, Charles, Sharp, Phillip A., Giallourakis, Cosmas C., Young, Richard A.

“…Many long noncoding RNA (lncRNA) species have been identified in mammalian cells, but the genomic origin and regulation of these molecules in individual cell…”
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Impact of Body Mass Index on the Efficacy of Endocrine Therapy in Premenopausal Patients With Breast Cancer: An Analysis of the Prospective ABCSG-12 Trial by PFEILER, Georg, KÖNIGSBERG, Robert, TAUCHER, Susanne, SAMONIGG, Hellmut, BJELIC-RADISIC, Vesna, GREIL, Richard, MARTH, Christian, GNANT, Michael, FESL, Christian, MLINERITSCH, Brigitte, STOEGER, Herbert, SINGER, Christian F, PÖSTLBERGER, Sabine, STEGER, Guenther G, SEIFERT, Michael, DUBSKY, Peter

“…Aromatase inhibitors are effective as endocrine treatment for patients with hormone receptor-positive breast cancer. According to the hypothesis that…”
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Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03) by Gnant, Michael, Dueck, Amylou C, Frantal, Sophie, Martin, Miguel, Burstein, Hal J, Greil, Richard, Fox, Peter, Wolff, Antonio C, Chan, Arlene, Winer, Eric P, Pfeiler, Georg, Miller, Kathy D, Colleoni, Marco, Suga, Jennifer M, Rubovsky, Gabor, Bliss, Judith M, Mayer, Ingrid A, Singer, Christian F, Nowecki, Zbigniew, Hahn, Olwen, Thomson, Jacqui, Wolmark, Norman, Amillano, Kepa, Rugo, Hope S, Steger, Guenther G, Hernando Fernández de Aránguiz, Blanca, Haddad, Tufia C, Perelló, Antonia, Bellet, Meritxell, Fohler, Hannes, Metzger Filho, Otto, Jallitsch-Halper, Anita, Solomon, Kadine, Schurmans, Céline, Theall, Kathy P, Lu, Dongrui R, Tenner, Kathleen, Fesl, Christian, DeMichele, Angela, Mayer, Erica L

“…Palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor approved for advanced breast cancer. In the adjuvant setting, the potential value of adding…”
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Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells by Guenther, Matthew G., Frampton, Garrett M., Soldner, Frank, Hockemeyer, Dirk, Mitalipova, Maya, Jaenisch, Rudolf, Young, Richard A.

“…Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells…”
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Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells by Marson, Alexander, Levine, Stuart S., Cole, Megan F., Frampton, Garrett M., Brambrink, Tobias, Johnstone, Sarah, Guenther, Matthew G., Johnston, Wendy K., Wernig, Marius, Newman, Jamie, Calabrese, J. Mauro, Dennis, Lucas M., Volkert, Thomas L., Gupta, Sumeet, Love, Jennifer, Hannett, Nancy, Sharp, Phillip A., Bartel, David P., Jaenisch, Rudolf, Young, Richard A.

“…MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by…”
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Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial by Gnant, Michael, Prof, Pfeiler, Georg, MD, Dubsky, Peter C, MD, Hubalek, Michael, MD, Greil, Richard, Prof, Jakesz, Raimund, Prof, Wette, Viktor, MD, Balic, Marija, MD, Haslbauer, Ferdinand, MD, Melbinger, Elisabeth, MD, Bjelic-Radisic, Vesna, MD, Artner-Matuschek, Silvia, MD, Fitzal, Florian, MD, Marth, Christian, Prof, Sevelda, Paul, MD, Mlineritsch, Brigitte, MD, Steger, Günther G, MD, Manfreda, Diether, MD, Exner, Ruth, MD, Egle, Daniel, MD, Bergh, Jonas, Prof, Kainberger, Franz, MD, Talbot, Susan, MSc, Warner, Douglas, MD, Fesl, Christian, PhD, Singer, Christian F, Prof

“…Summary Background Adjuvant endocrine therapy compromises bone health in patients with breast cancer, causing osteopenia, osteoporosis, and fractures…”
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The effect of platinum on carbon corrosion behavior in polymer electrolyte fuel cells by Linse, Nicolas, Gubler, Lorenz, Scherer, Günther G., Wokaun, Alexander

“…► The catalytic effect of platinum on carbon corrosion in PEFCs was investigated. ► Platinum catalyzes the carbon corrosion reaction. ► Catalytic effect…”
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A potential vorticity-based determination of the transport barrier in the Asian summer monsoon anticyclone by Ploeger, F, Gottschling, C, Griessbach, S, Grooß, J.-U, Guenther, G, Konopka, P, Müller, R, Riese, M, Stroh, F, Tao, M, Ungermann, J, Vogel, B, von Hobe, M

“…The Asian summer monsoon provides an important pathway of tropospheric source gases and pollution into the lower stratosphere. This transport is characterized…”
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Randomized Active-Controlled Phase II Study of Denosumab Efficacy and Safety in Patients With Breast Cancer-Related Bone Metastases by LIPTON, Allan, STEGER, Guenther G, COLEMAN, Robert, PATERSON, Alexander H. G, PETERSON, Mark C, FAN, Michelle, KINSEY, Amy, JUN, Susie, FIGUEROA, Jazmin, ALVARADO, Cristina, SOLAL-CELIGNY, Philippe, BODY, Jean-Jacques, DE BOER, Richard, BERARDI, Rossana, GASCON, Pere, TONKIN, Katia S

“…Denosumab, a fully human monoclonal antibody to receptor activator of nuclear factor-kappaB ligand, suppresses bone resorption. In this study, we evaluated the…”
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Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations by Lengner, Christopher J., Gimelbrant, Alexander A., Erwin, Jennifer A., Cheng, Albert Wu, Guenther, Matthew G., Welstead, G. Grant, Alagappan, Raaji, Frampton, Garrett M., Xu, Ping, Muffat, Julien, Santagata, Sandro, Powers, Doug, Barrett, C. Brent, Young, Richard A., Lee, Jeannie T., Jaenisch, Rudolf, Mitalipova, Maisam

“…The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs…”
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Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells by Boyer, Laurie A., Lee, Tong Ihn, Cole, Megan F., Johnstone, Sarah E., Levine, Stuart S., Zucker, Jacob P., Guenther, Matthew G., Kumar, Roshan M., Murray, Heather L., Jenner, Richard G., Gifford, David K., Melton, Douglas A., Jaenisch, Rudolf, Young, Richard A.

“…The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic…”
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Pathological complete remission and long-term outcome—what do we know in 2016? by Gnant, Michael, Steger, Guenther G, Bartsch, Rupert

“…In the NSABP trial B-27,4 sequential administration of doxorubicin and cyclophosphamide followed by docetaxel doubled the proportion of patients achieving…”
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