Search Results - "Guemouri, Sayeh"
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From genomic to LC-MS/MS evidence: Analysis of PfEMP1 in Benin malaria cases
Published in PloS one (28-06-2019)“…PfEMP1 is the major protein from parasitic origin involved in the pathophysiology of severe malaria, and PfEMP1 domain subtypes are associated with the…”
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Dynamics of Plasmodium falciparum gametocyte carriage in pregnant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Benin
Published in Malaria journal (11-10-2018)“…In sub-Saharan Africa, malaria is a major cause of morbidity and mortality, in particular in children and pregnant women. During pregnancy, Plasmodium…”
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Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: Impact on vaccine design for placental malaria
Published in Infection, genetics and evolution (01-07-2014)“…•VAR2CSA ID1-DBL2Xb is the leading candidate for the development of a vaccine against pregnancy-associated malaria.•It displays substantial sequence…”
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Epidemiology of drug‐resistant malaria in Republic of Congo: using molecular evidence for monitoring antimalarial drug resistance combined with assessment of antimalarial drug use
Published in Tropical medicine & international health (01-10-2005)“…Summary In Congo, urgent efforts are needed to help with the revision of the national antimalarial drug policy. Despite its high resistance level, chloroquine…”
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A Genotyping Study in Benin Comparing the Carriage of Plasmodium falciparum Infections Before Pregnancy and in Early Pregnancy: Story of a Persistent Infection
Published in Clinical infectious diseases (15-07-2021)“…Abstract Background Malaria infections in the first trimester of pregnancy are frequent and deleterious for both mother and child health. To investigate if…”
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Demonstration of a High Level of Parasite Population Homology by Quantification of Plasmodium falciparum Alleles in Matched Peripheral, Placental, and Umbilical Cord Blood Samples
Published in Journal of Clinical Microbiology (01-06-2005)“…Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three…”
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Transcriptome Analysis of Plasmodium falciparum Isolates From Benin Reveals Specific Gene Expression Associated With Cerebral Malaria
Published in The Journal of infectious diseases (15-06-2022)“…Abstract Cerebral malaria (CM) is the severest form of Plasmodium falciparum infection. Children under 5 years old are those most vulnerable to CM, and they…”
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Infected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria
Published in EMBO molecular medicine (15-02-2024)“…Cerebral malaria (CM), the most lethal complication of Plasmodium falciparum severe malaria (SM), remains fatal for 15–25% of affected children despite the…”
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Differential Protein Expression Profiles Between Plasmodium falciparum Parasites Isolated From Subjects Presenting With Pregnancy-Associated Malaria and Uncomplicated Malaria in Benin
Published in The Journal of infectious diseases (15-12-2013)“…Background. Plasmodium falciparum is responsible for severe malaria, including pregnancy-associated malaria (PAM). During intra-erythrocytic maturation, the…”
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PfEMP1 A-Type ICAM-1-Binding Domains Are Not Associated with Cerebral Malaria in Beninese Children
Published in mBio (17-11-2020)“…PfEMP1 is the major antigen involved in -infected erythrocyte sequestration in cerebrovascular endothelium. While some PfEMP1 domains have been associated with…”
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Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria
Published in Infectious diseases of poverty (09-02-2023)“…Cerebral malaria (CM) is a neuropathology which remains one of the deadliest forms of malaria among African children. The kinetics of the pathophysiological…”
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Non-traumatic coma in young children in Benin: are viral and bacterial infections gaining ground on cerebral malaria?
Published in Infectious diseases of poverty (14-03-2022)“…While malaria morbidity and mortality have declined since 2000, viral central nervous system infections appear to be an important, underestimated cause of coma…”
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Identification of Plasmodium falciparum and host factors associated with cerebral malaria: description of the protocol for a prospective, case-control study in Benin (NeuroCM)
Published in BMJ open (28-05-2019)“…IntroductionIn 2016, an estimated 216 million cases and 445 000 deaths of malaria occurred worldwide, in 91 countries. In Benin, malaria causes 26.8% of…”
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Plasmodium falciparum genotype population dynamics in asymptomatic children from Senegal
Published in Microbes and infection (01-06-2006)“…In areas where malaria is endemic, infected individuals generally harbor a mixture of genetically distinct Plasmodium falciparum parasite populations. For the…”
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High prevalence of Plasmodium falciparumpfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal
Published in Journal of antimicrobial chemotherapy (01-05-2005)Get full text
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High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal
Published in Journal of antimicrobial chemotherapy (01-05-2005)“…Objectives: The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite…”
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Kinetics of monocyte subpopulations during experimental cerebral malaria and its resolution in a model of late chloroquine treatment
Published in Frontiers in cellular and infection microbiology (14-10-2022)“…Cerebral malaria (CM) is one of the most severe forms of malaria and is a neuropathology that can lead to death. Monocytes have been shown to accumulate in the…”
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