Search Results - "Guehl, Nicolas"

Kinetic evaluation and assessment of longitudinal changes in reference region and extracerebral [18F]MK-6240 PET uptake by Fu, Jessie Fanglu, Lois, Cristina, Sanchez, Justin, Becker, J Alex, Rubinstein, Zoe B, Thibault, Emma, Salvatore, Andrew N, Sari, Hasan, Farrell, Michelle E, Guehl, Nicolas J, Normandin, Marc D, Fakhri, Georges El, Johnson, Keith A, Price, Julie C

“…[18F]MK-6240 meningeal/extracerebral off-target binding may impact tau quantification. We examined the kinetics and longitudinal changes of extracerebral and…”
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Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue by Aguero, Cinthya, Dhaynaut, Maeva, Normandin, Marc D, Amaral, Ana C, Guehl, Nicolas J, Neelamegam, Ramesh, Marquie, Marta, Johnson, Keith A, El Fakhri, Georges, Frosch, Matthew P, Gomez-Isla, Teresa

“…[F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the…”
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PET mapping of receptor occupancy using joint direct parametric reconstruction by Marin, Thibault, Belov, Vasily, Chemli, Yanis, Ouyang, Jinsong, Najmaoui, Yassir, Fakhri, Georges El, Duvvuri, Sridhar, Iredale, Philip, Guehl, Nicolas J., Normandin, Marc D., Petibon, Yoann

“…Receptor occupancy (RO) studies using PET neuroimaging play a critical role in the development of drugs targeting the central nervous system (CNS). The…”
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Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects by Guehl, Nicolas J., Wooten, Dustin W., Yokell, Daniel L., Moon, Sung-Hyun, Dhaynaut, Maeva, Katz, Samantha, Moody, Kirsten A., Gharagouzloo, Codi, Kas, Aurélie, Johnson, Keith A., El Fakhri, Georges, Normandin, Marc D.

“…Purpose [ 18 F]MK6240 was developed for PET imaging of tau aggregates, which are implicated in Alzheimer’s disease. The goal of this work was to evaluate the…”
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Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer's Disease: A Case Series by Dhaynaut, Maeva, Sprugnoli, Giulia, Cappon, Davide, Macone, Joanna, Sanchez, Justin S, Normandin, Marc D, Guehl, Nicolas J, Koch, Giacomo, Paciorek, Rachel, Connor, Ann, Press, Daniel, Johnson, Keith, Pascual-Leone, Alvaro, El Fakhri, Georges, Santarnecchi, Emiliano

“…Alzheimer's disease (AD) is characterized by diffuse amyloid-β (Aβ) and phosphorylated Tau (p-Tau) aggregates as well as neuroinflammation. Exogenously-induced…”
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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging by Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas J., Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., El Fakhri, Georges, Kurumbail, Ravi G., Vasdev, Neil

“…Glycogen synthase kinase‐3 (GSK‐3) regulates multiple cellular processes in diabetes, oncology, and neurology…”
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PET imaging studies to investigate functional expression of mGluR2 using [11C]mG2P001 by Yuan, Gengyang, Dhaynaut, Maeva, Guehl, Nicolas J, Neelamegam, Ramesh, Moon, Sung-Hyun, Qu, Xiying, Poutiainen, Pekka, Afshar, Sepideh, Fakhri, Georges El, Normandin, Marc D, Brownell, Anna-Liisa

“…Metabotropic glutamate receptor 2 (mGluR2) has been extensively studied for the treatment of various neurological and psychiatric disorders. Understanding of…”
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PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator by Belov, Vasily, Guehl, Nicolas J, Duvvuri, Sridhar, Iredale, Philip, Moon, Sung-Hyun, Dhaynaut, Maeva, Chakilam, Srinivas, MacDonagh, Alexander C, Rice, Peter A, Yokell, Daniel L, Renger, John J, El Fakhri, Georges, Normandin, Marc D

“…Stimulation of the M4 muscarinic acetylcholine receptor reduces striatal hyperdopaminergia, suggesting its potential as a therapeutic target for schizophrenia…”
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Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR by Petibon, Yoann, Guehl, Nicolas J, Reese, Timothy G, Ebrahimi, Behzad, Normandin, Marc D, Shoup, Timothy M, Alpert, Nathaniel M, El Fakhri, Georges, Ouyang, Jinsong

“…PET is an established modality for myocardial perfusion imaging (MPI) which enables quantification of absolute myocardial blood flow (MBF) using dynamic…”
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Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors by Zhukovsky, Peter, Ironside, Maria, Duda, Jessica M., Moser, Amelia D., Null, Kaylee E., Dhaynaut, Maeva, Normandin, Marc, Guehl, Nicolas J., El Fakhri, Georges, Alexander, Madeline, Holsen, Laura M., Misra, Madhusmita, Narendran, Rajesh, Hoye, Jocelyn M., Morris, Evan D., Esfand, Shiba M., Goldstein, Jill M., Pizzagalli, Diego A.

“…Understanding the neurobiological effects of stress is critical for addressing the etiology of major depressive disorder (MDD). Using a dimensional approach…”
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PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study by Detmer, Felicitas J., Alpert, Nathaniel M., Moon, Sung-Hyun, Dhaynaut, Maeva, Guerrero, J. Luis, Guehl, Nicolas J., Xing, Fangxu, Brugarolas, Pedro, Shoup, Timothy M., Normandin, Marc D., Pelletier-Galarneau, Matthieu, El Fakhri, Georges, Petibon, Yoann

“…Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this proof-of-principle study, we investigated whether PET mapping…”
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Measurement of Cerebral Perfusion Indices from the Early Phase of [ 18 F]MK6240 Dynamic Tau PET Imaging by Guehl, Nicolas J, Dhaynaut, Maeva, Hanseeuw, Bernard J, Moon, Sung-Hyun, Lois, Cristina, Thibault, Emma, Fu, Jessie Fanglu, Price, Julie C, Johnson, Keith A, El Fakhri, Georges, Normandin, Marc D

“…6-(fluoro- F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([ F]MK6240) has high affinity and selectivity for hyperphosphorylated tau and readily…”
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Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques by Guehl, Nicolas J, Ramos-Torres, Karla M, Linnman, Clas, Moon, Sung-Hyun, Dhaynaut, Maeva, Wilks, Moses Q, Han, Paul K, Ma, Chao, Neelamegam, Ramesh, Zhou, Yu-Peng, Popko, Brian, Correia, John A, Reich, Daniel S, Fakhri, Georges El, Herscovitch, Peter, Normandin, Marc D, Brugarolas, Pedro

“…Demyelination causes slowed or failed neuronal conduction and is a driver of disability in multiple sclerosis and other neurological diseases. Currently, the…”
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Design, Synthesis, and Characterization of [18F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2 by Yuan, Gengyang, Dhaynaut, Maeva, Guehl, Nicolas J., Afshar, Sepideh, Huynh, Dalena, Moon, Sung-Hyun, Iyengar, Suhasini M., Jain, Manish Kumar, Pickett, Julie E., Kang, Hye Jin, Ondrechen, Mary Jo, El Fakhri, Georges, Normandin, Marc D., Brownell, Anna-Liisa

“…An array of triazolopyridines based on JNJ-46356479 (6) were synthesized as potential positron emission tomography radiotracers for metabotropic glutamate…”
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Reply to: Fitting of late dynamic [18F]MK6240 PET scans for in vivo tau quantification by Guehl, Nicolas J., Wooten, Dustin W., El Fakhri, Georges, Normandin, Marc D.

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Synthesis and Characterization of 5‑(2-Fluoro-4‑[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro‑2H‑pyrano[2,3‑b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2 by Yuan, Gengyang, Dhaynaut, Maeva, Lan, Yu, Guehl, Nicolas J, Huynh, Dalena, Iyengar, Suhasini M, Afshar, Sepideh, Jain, Manish Kumar, Pickett, Julie E, Kang, Hye Jin, Wang, Hao, Moon, Sung-Hyun, Ondrechen, Mary Jo, Wang, Changning, Shoup, Timothy M, El Fakhri, Georges, Normandin, Marc D, Brownell, Anna-Liisa

“…Metabotropic glutamate receptor 2 (mGluR2) is a therapeutic target for several neuropsychiatric disorders. An mGluR2 function in etiology could be unveiled by…”
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Injectable ice slurry for reducing pericardial adipose tissue by Shuhaiber, Jeffrey, Moradi Tuchayi, Sara, Bijari, Felicitas J., Guehl, Nicolas J., Wang, Ying, Farinelli, William A., Arkun, Knarik, El Fakhri, Georges, Anderson, Richard R., Garibyan, Lilit

“…Objectives Excess pericardial adipose tissue (PAT) is associated with a higher risk of cardiovascular diseases. Currently, available methods for reducing PAT…”
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Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP by Brugarolas, Pedro, Wilks, Moses Q., Noel, Jacqueline, Kaiser, Julia-Ann, Vesper, Danielle R., Ramos-Torres, Karla M., Guehl, Nicolas J., Macdonald-Soccorso, Marina T., Sun, Yang, Rice, Peter A., Yokell, Daniel L., Lim, Ruth, Normandin, Marc D., El Fakhri, Georges

“…Purpose [ 18 F]3F4AP is a novel PET radiotracer that targets voltage-gated potassium (K + ) channels and has shown promise for imaging demyelinated lesions in…”
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Correction to: Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects by Guehl, Nicolas J., Wooten, Dustin W., Yokell, Daniel L., Moon, Sung-Hyun, Dhaynaut, Maeva, Katz, Samantha, Moody, Kirsten A., Gharagouzloo, Codi, Kas, Aurélie, Johnson, Keith A., Fakhri, Georges El, Normandin, Marc D.

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In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study by Pelletier-Galarneau, Matthieu, Petibon, Yoann, Ma, Chao, Han, Paul, Kim, Sally Ji Who, Detmer, Felicitas J., Yokell, Daniel, Guehl, Nicolas, Normandin, Marc, El Fakhri, Georges, Alpert, Nathaniel M.

“…Purpose Alteration in mitochondrial membrane potential (ΔΨ m ) is an important feature of many pathologic processes, including heart failure, cardiotoxicity,…”
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