Search Results - "Guedes, Paulo M.M."

Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins by De Araújo, Jr, Raimundo F, Pessoa, Jonas B, Cruz, Luis J, Chan, Alan B, De Castro Miguel, Emílio, Cavalcante, Rômulo S, Brito, Gerly Anne C, Silva, Heloiza Fernada O, Gasparotto, Luiz H S, Guedes, Paulo M M, Araújo, Aurigena A

“…In cancers, apoptosis signaling pathways and cell survival and growth pathways responsible for resistance to conventional treatments, such as Pi3K/Akt/mTOR and…”
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The Effects of Nitric Oxide on the Immune System During Trypanosoma Cruzi Infection by Gutierrez, Fredy R.S, Mineo, Tiago W.P, Pavanelli, Wander R, Guedes, Paulo M.M, Silva, João S

“…Trypanosoma cruzi infection triggers substantial production of nitric oxide (NO), which has been shown to have protective and toxic effects on the host's…”
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Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1 by Gutierrez, Fredy R.S, Mariano, Flávia S, Oliveira, Carlo J.F, Pavanelli, Wander R, Guedes, Paulo M.M, Silva, Grace K, Campanelli, Ana P, Milanezi, Cristiane M, Azuma, Miyuki, Honjo, Tasuku, Teixeira, Mauro M, Aliberti, Julio C.S, Silva, João S

“…Trypanosoma cruzi infection causes intense myocarditis, leading to cardiomyopathy and severe cardiac dysfunction. Protective adaptive immunity depends on…”
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Development of chronic cardiomyopathy in canine Chagas disease correlates with high IFN-γ, TNF-α, and low IL-10 production during the acute infection phase by Guedes, Paulo M.M., Veloso, Vanja M., Afonso, Luis C.C., Caliari, Marcelo V., Carneiro, Cláudia M., Diniz, Lívia F., Marques-da-Silva, Eduardo A., Caldas, Ivo S., Do Valle Matta, Maria A., Souza, Sheler M., Lana, Marta, Chiari, Egler, Galvão, Lúcia M.C., Bahia, Maria T.

“…When infected with Trypanosoma cruzi, Beagle dogs develop symptoms similar to those of Chagas disease in human beings, and could be an important experimental…”
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Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in Beagle dogs by Guedes, Paulo M.M., Veloso, Vanja M., Talvani, André, Diniz, Livia F., Caldas, Ivo S., Do-Valle-Matta, Maria A., Santiago-Silva, Juliana, Chiari, Egler, Galvão, Lucia M.C., Silva, João S., Bahia, Maria T.

“…Chemokines and chemokine receptors interaction have presented important role in leukocyte migration to specific immune reaction sites. Recently, it has been…”
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IgG isotype profile is correlated with cardiomegaly in Beagle dogs infected with distinct Trypanosoma cruzi strains by Guedes, Paulo M.M., Veloso, Vanja M., Gollob, Kenneth J., Afonso, Luis C.C., Caldas, Ivo S., Vianna, Priscila, de Lana, Marta, Chiari, Egler, Bahia, Maria T., Galvão, Lúcia M.C.

“…A systematic study following infection by various strains of the protozoan parasite, Trypanosoma cruzi, and the simultaneous monitoring of the humoral immune…”
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Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino by Vanessa L. Santana, Almir P. Souza, Dayanne A.S.D. Lima, Ana L. Araújo, Soraia V. Justiniano, Raiara P. Dantas, Paulo M.M. Guedes, Márcia A. Melo

“…Objetivou-se, com este estudo, evidenciar os sinais clínicos e laboratoriais desta enfermidade para auxiliar na caracterização da doença de forma natural na…”
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‘Click chemistry’ synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase by Carvalho, Ivone, Andrade, Peterson, Campo, Vanessa L., Guedes, Paulo M.M., Sesti-Costa, Renata, Silva, João S., Schenkman, Sergio, Dedola, Simone, Hill, Lionel, Rejzek, Martin, Nepogodiev, Sergey A., Field, Robert A.

“…A 46-membered library of galactose-based triazoles was synthesized by ‘click chemistry’. These compounds proved to be weak substrate analogue inhibitors of…”
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Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection by Silva, Grace K, Gutierrez, Fredy R. S, Guedes, Paulo M. M, Horta, Catarina V, Cunha, Larissa D, Mineo, Tiago W. P, Santiago-Silva, Juliana, Kobayashi, Koichi S, Flavell, Richard A, Silva, Joao S, Zamboni, Dario S

“…An effective innate immune recognition of the intracellular protozoan parasite Trypanosoma cruzi is critical for host resistance against Chagas disease, a…”
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Current status of Chagas disease chemotherapy by Guedes, Paulo M M, Silva, Grace K, Gutierrez, Fredy R S, Silva, João S

“…Chagas disease affects 7.7 million people and 28 million people are at risk of acquiring the disease in 15 endemic countries of Latin America. Benznidazole and…”
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The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa , Attenuated Colon Damage in Murine Colitis Model by Lucena, Alessandra M M, Souza, Cássio R M, Jales, Jéssica T, Guedes, Paulo M M, de Miranda, George E C, de Moura, Adolpho M A, Araújo-Júnior, João X, Nascimento, George J, Scortecci, Kátia C, Santos, Barbara V O, Souto, Janeusa T

“…Caulerpin (CLP), an alkaloid from algae of the genus Caulerpa, has shown anti-inflammatory activity. Therefore, this study aimed to analyze the effect of CLP…”
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Glycoclusters presenting lactose on calix[4]arene cores display trypanocidal activity by Galante, Eva, Geraci, Corrada, Sciuto, Sebastiano, Campo, Vanessa L., Carvalho, Ivone, Sesti-Costa, Renata, Guedes, Paulo M.M., Silva, João S., Hill, Lionel, Nepogodiev, Sergey A., Field, Robert A.

“…A new series of water-soluble tetravalent glycoclusters incorporating β-lactosyl residues attached to a central calix[4]arene core was synthesised using…”
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The use of a heterogeneously controlled mouse population reveals a significant correlation of acute phase parasitemia with mortality in Chagas disease by Sanches, Tiago L M, Cunha, Larissa D, Silva, Grace K, Guedes, Paulo M M, Silva, João Santana, Zamboni, Dario S

“…Chagas disease develops upon infection with the protozoan parasite Trypanosoma cruzi and undergoes an acute phase characterized by massive parasite replication…”
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Haeme oxygenase activity protects the host against excessive cardiac inflammation during experimental Trypanosoma cruzi infection by Gutierrez, Fredy R.S., Pavanelli, Wander R., Medina, Tiago S., Silva, Grace K., Mariano, Flávia S., Guedes, Paulo M.M., Mineo, Tiago W.P., Rossi, Marcos A., Cunha, Fernando Q., Silva, João S.

“…The infection with Trypanosoma cruzi induces a robust cardiac inflammation that plays a pathogenic role in the development of Chagas heart disease. In this…”
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Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence by Santos, Ramon F, Pôssa, Marcela A S, Bastos, Matheus S, Guedes, Paulo M M, Almeida, Márcia R, Demarco, Ricardo, Verjovski-Almeida, Sergio, Bahia, Maria T, Fietto, Juliana L R

“…The protozoan Trypanosoma cruzi is the causative agent of Chagas disease. There are no vaccines or effective treatment, especially in the chronic phase when…”
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Naturally Leishmania infantum-infected dogs display an overall impairment of chemokine and chemokine receptor expression during visceral leishmaniasis by Nascimento, Manuela S.L., Albuquerque, Talyta D.R., Do-Valle-Matta, Maria A., Caldas, Ivo S., Diniz, Lívia F., Talvani, André, Bahia, Maria T., Andrade, Cléber M., Galvão, Lúcia M.C., Câmara, Antônia C.J., Guedes, Paulo M.M.

“…Dogs are the primary reservoir for Leishmania parasites. The immune response induced by Leishmania infantum infection in these animals has not been completely…”
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Protein deficiency alters CX3CL1 and endothelin‐1 in experimental Trypanosoma cruzi‐induced cardiomyopathy by Martins, Régia F., Martinelli, Patrícia M., Guedes, Paulo M. M., Cruz Pádua, Bruno, Santos, Fabiana M., Silva, Marcelo Eustáquio, Bahia, Maria T., Talvani, Andre

“…Objective Chagas heart disease is developed as a result of the infection with Trypanosoma cruzi. Protein malnutrition contributes to secondary…”
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Immunological imbalance between IFN-γ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease by D'Ávila, Daniela A, Guedes, Paulo MM, Castro, Ana M, Gontijo, Eliane D, Chiari, Egler, Galvão, Lúcia MC

“…The immune response is crucial for protection against disease; however, immunological imbalances can lead to heart and digestive tract lesions in chagasic…”
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Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino by Santana, Vanessa L., Souza, Almir P., Lima, Dayanne A.S.D., Araújo, Ana L., Justiniano, Soraia V., Dantas, Raiara P., Guedes, Paulo M.M., Melo, Márcia A.

“…Objetivou-se, com este estudo, evidenciar os sinais clínicos e laboratoriais desta enfermidade para auxiliar na caracterização da doença de forma natural na…”
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Trypanosoma cruzi : blood parasitism kinetics and their correlation with heart parasitism intensity during long-term infection of Beagle dogs by Veloso, Vanja M, Guedes, Paulo MM, Andrade, Isabel M, Caldas, Ivo S, Martins, Helen R, Carneiro, Cláudia M, Machado-Coelho, George LL, de Lana, Marta, Galvão, Lúcia MC, Bahia, Maria T, Chiari, Egler

“…The goals of the present study were to evaluate the kinetics of blood parasitism by examination of fresh blood, blood culture (BC) and PCR assays and their…”
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