Search Results - "Gueble, Susan E."

Mechanism-based design of agents that selectively target drug-resistant glioma by Lin, Kingson, Gueble, Susan E, Sundaram, Ranjini K, Huseman, Eric D, Bindra, Ranjit S, Herzon, Seth B

“…Approximately half of glioblastoma and more than two-thirds of grade II and III glioma tumors lack the DNA repair protein O -methylguanine methyl transferase…”
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Oncometabolites as Regulators of DNA Damage Response and Repair by Gueble, Susan E., Bindra, Ranjit S.

“…Dysregulation of DNA damage response and repair (DDR) contributes to oncogenesis, yet also generates the potential for targeted cancer therapies by exploiting…”
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The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors by Gueble, Susan E., Vasquez, Juan C., Bindra, Ranjit S.

“…Opinion statement Primary malignant central nervous (CNS) tumors are a devastating group of diseases with urgent need for improved treatment options. Surgery,…”
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Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers by Huseman, Eric D., Lo, Anna, Fedorova, Olga, Elia, James L., Gueble, Susan E., Lin, Kingson, Sundaram, Ranjini K., Oh, Joonseok, Liu, Jinchan, Menges, Fabian, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Batista, Victor S., Crawford, Jason M., Pyle, Anna M., Bindra, Ranjit S., Herzon, Seth B.

“…Aberrant DNA repair is a hallmark of cancer, and many tumors display reduced DNA repair capacities that sensitize them to genotoxins. Here, we demonstrate that…”
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