Search Results - "Gudzera, Olga I"

Probing the Molecular Basis of Aminoacyl-Adenylate Affinity With Mycobacterium tuberculosis Leucyl-tRNA Synthetase Employing Molecular Dynamics, Umbrella Sampling Simulations and Site-Directed Mutagenesis by Volynets, Galyna P, Gudzera, Olga I, Usenko, Mariia O, Gorbatiuk, Oksana B, Bdzhola, Volodymyr G, Kotey, Igor M, Balanda, Anatoliy O, Prykhod'ko, Andrii O, Lukashov, Sergiy S, Chuk, Oleksiy A, Skydanovych, Oleksandra I, Yaremchuk, Ganna D, Yarmoluk, Sergiy M, Tukalo, Michael A

“…Leucyl-tRNA synthetase (LeuRS) is clinically validated molecular target for antibiotic development. Recently, we have reported several classes of…”
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Rational Design of Hit Compounds Targeting Staphylococcus aureus Threonyl-tRNA Synthetase by Rybak, Mariia Yu, Gudzera, Olga I, Gorbatiuk, Oksana B, Usenko, Mariia O, Yarmoluk, Sergiy M, Tukalo, Michael A, Volynets, Galyna P

“…Staphylococcus aureus is one of the most dangerous nosocomial pathogens which cause a wide variety of hospital-acquired infectious diseases. S. aureus is…”
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Probing interactions of aminoacyl-adenylate with Mycobacterium tuberculosis methionyl-tRNA synthetase through in silico site-directed mutagenesis and free energy calculation by Volynets, Galyna P., Gudzera, Olga I., Usenko, Mariia O., Gorbatiuk, Oksana B., Yarmoluk, Sergiy M., Tukalo, Michael A.

“…Methionyl-tRNA synthetase (MetRS) is an attractive molecular target for antibiotic discovery. Recently, we have developed several classes of small-molecular…”
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Identification of novel antistaphylococcal hit compounds by Volynets, Galyna P., Iungin, Olga S., Gudzera, Olga I., Vyshniakova, Hanna V., Rybak, Mariia Yu, Moshynets, Olena V., Balanda, Anatoliy O., Borovykov, Oleksiy V., Prykhod’ko, Andrii O., Lukashov, Sergiy S., Maiula, Taras H., Pletnova, Larysa V., Yarmoluk, Sergiy M., Tukalo, Michael A.

“…Staphylococcus aureus is one of the most common nosocomial biofilm-forming pathogens worldwide that has developed resistance mechanisms against majority of the…”
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Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase by Gudzera, Olga I., Golub, Andriy G., Bdzhola, Volodymyr G., Volynets, Galyna P., Lukashov, Sergiy S., Kovalenko, Oksana P., Kriklivyi, Ivan A., Yaremchuk, Anna D., Starosyla, Sergiy A., Yarmoluk, Sergiy M., Tukalo, Michail A.

“…[Display omitted] Tuberculosis is a serious infectious disease caused by human pathogen bacteria Mycobacterium tuberculosis. Bacterial drug resistance is a…”
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Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N -benzylidene- N '-thiazol-2-yl-hydrazines by Kovalenko, Oksana P, Volynets, Galyna P, Rybak, Mariia Yu, Starosyla, Sergiy A, Gudzera, Olga I, Lukashov, Sergiy S, Bdzhola, Volodymyr G, Yarmoluk, Sergiy M, Boshoff, Helena I, Tukalo, Michael A

“…Effective treatment of tuberculosis is challenged by the rapid development of ( ) multidrug resistance that presumably could be overcome with novel…”
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Identification of Dual-Targeted Mycobacterium Tuberculosis Aminoacyl-tRNA Synthetase Inhibitors Using Machine Learning by Volynets, Galyna P, Usenko, Mariia O, Gudzera, Olga I, Starosyla, Segiy A, Balanda, Anatoliy O, Syniugin, Anatolii R, Gorbatiuk, Oksana B, Prykhod'ko, Andrii O, Bdzhola, Volodymyr G, Yarmoluk, Sergiy M, Tukalo, Michael A

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Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one by Gudzera, Olga I, Golub, Andriy G, Bdzhola, Volodymyr G, Volynets, Galyna P, Kovalenko, Oksana P, Boyarshin, Konstantin S, Yaremchuk, Anna D, Protopopov, Mykola V, Yarmoluk, Sergiy M, Tukalo, Michail A

“…The increase of antibiotic resistance amongst Mycobacterium tuberculosis strains has become one of the most pressing problems of modern medicine. Therefore,…”
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Stereospecificity control in aminoacyl-tRNA-synthetases: new evidence of d-amino acids activation and editing by Rybak, Mariia Yu, Rayevsky, Alexey V, Gudzera, Olga I, Tukalo, Michael A

“…Abstract The homochirality of amino acids is vital for the functioning of the translation apparatus. l-Amino acids predominate in proteins and d-amino acids…”
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Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among -benzylidene-′-thiazol-2-yl-hydrazines by Kovalenko, Oksana P, Volynets, Galyna P, Rybak, Mariia Yu, Starosyla, Sergiy A, Gudzera, Olga I, Lukashov, Sergiy S, Bdzhola, Volodymyr G, Yarmoluk, Sergiy M, Boshoff, Helena I, Tukalo, Michael A

“…Effective treatment of tuberculosis is challenged by the rapid development of Mycobacterium tuberculosis ( Mtb ) multidrug resistance that presumably could be…”
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Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N′-thiazol-2-yl-hydrazines† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00347a by Kovalenko, Oksana P., Volynets, Galyna P., Rybak, Mariia Yu, Starosyla, Sergiy A., Gudzera, Olga I., Lukashov, Sergiy S., Bdzhola, Volodymyr G., Yarmoluk, Sergiy M., Boshoff, Helena I., Tukalo, Michael A.

“…A screen of 37 compounds identified four inhibitors that exhibited dual on-target activity against Mycobacterium tuberculosis aminoacyl-tRNA synthetases…”
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