Search Results - "Gudjonsson, J."

Immunopathogenic mechanisms in psoriasis by GUDJONSSON, J. E., JOHNSTON, A., SIGMUNDSDOTTIR, H., VALDIMARSSON, H.

“…SUMMARY Psoriasis is a common autoimmune skin disease characterized by T cell‐mediated hyperproliferation of keratinocytes. The disease has a strong but…”
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Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation by Johnston, A., Arnadottir, S., Gudjonsson, J.E., Aphale, A., Sigmarsdottir, A.A., Gunnarsson, S.I., Steinsson, J.T., Elder, J.T., Valdimarsson, H.

“…Summary Background  Obesity is a significant risk factor for psoriasis and body mass index (BMI) correlates with disease severity. Objectives  To investigate…”
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Early tissue responses in psoriasis to the antitumour necrosis factor-α biologic etanercept suggest reduced interleukin-17 receptor expression and signalling by Johnston, A., Guzman, A.M., Swindell, W.R., Wang, F., Kang, S., Gudjonsson, J.E.

“…Summary Background Antitumour necrosis factor (anti‐TNF)‐α therapy has made a significant impact on the treatment of psoriasis. Despite these agents being…”
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Still waters run deep: latent cytokine activity in nonlesional psoriasis skin by Johnston, A., Yin, Z., Gudjonsson, J.E.

“…Linked Article: Chiricozzi, et al. Br J Dermatol 2016; 174: 136–45…”
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Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin‐homing CD8+ T cells by JOHNSTON, A., GUDJONSSON, J. E., SIGMUNDSDOTTIR, H., LOVE, T. J., VALDIMARSSON, H.

“…SUMMARY The association of psoriasis with Streptococcus pyogenes throat infections suggests a potential antigenic target for the T cells that are known to…”
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Cutaneous manifestations of hospitalized coronavirus disease 2019 patients: a report of six cases with clinicopathologic features and viral RNA in situ hybridization by Bitar, C., Chan, M.P., Harms, P.W., Fullen, D.R., Gudjonsson, J.E., Eshaq, M., Renati, S., Nikle, A.B., Allen, A., Hawkins, S.D., Huerta, T., Lowe, L., Andea, A.A.

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Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study by Gudjonsson, J.E., Thorarinsson, A.M., Sigurgeirsson, B., Kristinsson, K.G., Valdimarsson, H.

“…Summary Background  Guttate psoriasis has a well‐known association with streptococcal throat infections but the effects of these infections in patients with…”
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Small joint involvement in psoriatic arthritis is associated with onycholysis: the Reykjavik Psoriatic Arthritis Study by Love, TJ, Gudjonsson, JE, Valdimarsson, H, Gudbjornsson, B

“…Objectives: Psoriasis and psoriatic arthritis (PsA) are associated with nail changes. Recent reports suggest that nail changes may be a part of the enthesitis…”
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Transcriptome mining and B cell depletion support a role for B cells in psoriasis pathophysiology by Toussi, A., Merleev, A., Barton, V.R., Le, S.T., Marusina, A., Luxardi, G., Kirma, J., Xing, X., Adamopoulos, I.E., Fung, MA, Raychaudhuri, S.P, Shimoda, M, Gudjonsson, J.E., Maverakis, E.

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Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)‐19, IL‐20 and IL‐24 by Wang, F., Smith, N., Maier, L., Xia, W., Hammerberg, C., Chubb, H., Chen, C., Riblett, M., Johnston, A., Gudjonsson, J.E., Helfrich, Y., Kang, S., Fisher, G.J., Voorhees, J.J.

“…Summary Background  Psoriasis is a Th17/Th1‐mediated skin disease that often responds to antitumour necrosis factor (TNF)‐α therapies, such as etanercept…”
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Human Plasma‐Derived Mannose‐Binding Lectin: A Phase I Safety and Pharmacokinetic Study by Valdimarsson, H., Vikingsdottir, T., Bang, P., Saevarsdottir, S., Gudjonsson, J. E., Oskarsson, O., Christiansen, M., Blou, L., Laursen, I., Koch, C.

“…Mannose‐binding lectin (MBL) is an important component of innate immunity that can bind to certain sugar residues on the surface of many types of pathogenic…”
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Psoriasis patients who are homozygous for the HLA-Cw0602 allele have a 2.5-fold increased risk of developing psoriasis compared with Cw6 heterozygotes by GUDJONSSON, J. E, KARASON, A, ANTONSDOTTIR, A, RUNARSDOTTIR, E. H, HAUKSSON, V. B, UPMANYU, R, GULCHER, J, STEFANSSON, K, VALDIMARSSON, H

“…Psoriasis is strongly associated with certain human leucocyte-associated antigens, especially HLA-Cw*0602. Patients who are HLA-Cw*0602 positive have been…”
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Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24 by Wang, F., Smith, N., Maier, L., Xia, W., Hammerberg, C., Chubb, H., Chen, C., Riblett, M., Johnston, A., Gudjonsson, J.E., Helfrich, Y., Kang, S., Fisher, G.J., Voorhees, J.J.

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The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis by Sigmundsdottir, H., Gudjonsson, J.E., Valdimarsson, H.

“…Summary Background T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express…”
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LB1722 Ablating ATP2C1 in human keratinocytes impairs intercellular adhesion, disrupts epidermal integrity, and reveals therapeutic targets for Hailey-Hailey disease by Ayers, J.L., Tiwaa, A., Sarkar, M.K., Gudjonsson, J., Simpson, C.L.

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992 A new innovative approach combining comparative transcriptomics from three unique psoriasis models to identify predictive PsA biomarkers by Swindell, W.R., Gudjonsson, J., Ward, N.L.

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LB1703 High induction dosing of risankizumab in patients with moderate-to-severe plaque psoriasis: Interim results from the phase 2 KNOCKOUT study by Blauvelt, A., Gudjonsson, J., Matheson, R., Liu, R., Shi, L., Photowala, H., Ehst, B.

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LB1670 Activation of pro-fibrotic processes downstream of IL-31RA signaling distinguishes prurigo nodularis from atopic dermatitis by Chaskar, P.D., Ma, F., Van Delm, W., Piketty, C., Julia, V., Krishnaswamy, J., Gudjonsson, J.

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321 A human tissue model of Darier disease reveals MEK as a novel therapeutic target downstream of SERCA2 deficiency by Zaver, S.A., Sarkar, M., Tiwaa, A., Zou, J., Egolf, S., Capell, B., Gudjonsson, J., Simpson, C.L.

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373 Identification of immune cell pathways in acne vs. rosacea by single-cell RNA sequencing and single-cell spatial imaging by Do, T.H., Perrie, J., Pellegrini, M., Gudjonsson, J., Ma, F., Modlin, R.L.

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