Search Results - "Gudenas, Brian L."

Unified rhombic lip origins of group 3 and group 4 medulloblastoma by Smith, Kyle S., Bihannic, Laure, Gudenas, Brian L., Haldipur, Parthiv, Tao, Ran, Gao, Qingsong, Li, Yiran, Aldinger, Kimberly A., Iskusnykh, Igor Y., Chizhikov, Victor V., Scoggins, Matthew, Zhang, Silu, Edwards, Angela, Deng, Mei, Glass, Ian A., Overman, Lynne M., Millman, Jake, Sjoboen, Alexandria H., Hadley, Jennifer, Golser, Joseph, Mankad, Kshitij, Sheppard, Heather, Onar-Thomas, Arzu, Gajjar, Amar, Robinson, Giles W., Hovestadt, Volker, Orr, Brent A., Patay, Zoltán, Millen, Kathleen J., Northcott, Paul A.

“…Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach…”
Get full text

Integrative genomic analyses for identification and prioritization of long non-coding RNAs associated with autism by Gudenas, Brian L, Srivastava, Anand K, Wang, Liangjiang

“…Genetic studies have identified many risk loci for autism spectrum disorder (ASD) although causal factors in the majority of cases are still unknown…”
Get full text

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression by Schmidt, Christin, Cohen, Sarah, Gudenas, Brian L., Husain, Sarah, Carlson, Annika, Westelman, Samantha, Wang, Linyu, Phillips, Joanna J., Northcott, Paul A., Weiss, William A., Schwer, Bjoern

“…SNCAIP duplication may promote Group 4 medulloblastoma via induction of PRDM6, a poorly characterized member of the PRDF1 and RIZ1 homology domain-containing…”
Get full text

Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma by García-López, Jesus, Wallace, Kirby, Otero, Joel H., Olsen, Rachelle, Wang, Yong-dong, Finkelstein, David, Gudenas, Brian L., Rehg, Jerold E., Northcott, Paul, Davidoff, Andrew M., Freeman, Kevin W.

“…Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with…”
Get full text

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation by Kutscher, Lena M, Okonechnikov, Konstantin, Batora, Nadja V, Clark, Jessica, Silva, Patricia B G, Vouri, Mikaella, van Rijn, Sjoerd, Sieber, Laura, Statz, Britta, Gearhart, Micah D, Shiraishi, Ryo, Mack, Norman, Orr, Brent A, Korshunov, Andrey, Gudenas, Brian L, Smith, Kyle S, Mercier, Audrey L, Ayrault, Olivier, Hoshino, Mikio, Kool, Marcel, von Hoff, Katja, Graf, Norbert, Fleischhack, Gudrun, Bardwell, Vivian J, Pfister, Stefan M, Northcott, Paul A, Kawauchi, Daisuke

“…Medulloblastoma is a malignant childhood brain tumor arising from the developing cerebellum. In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant…”
Get full text

Prediction of LncRNA Subcellular Localization with Deep Learning from Sequence Features by Gudenas, Brian L., Wang, Liangjiang

“…Long non-coding RNAs are involved in biological processes throughout the cell including the nucleus, chromatin and cytosol. However, most lncRNAs remain…”
Get full text

Gene Coexpression Networks in Human Brain Developmental Transcriptomes Implicate the Association of Long Noncoding RNAs with Intellectual Disability by Gudenas, Brian L, Wang, Liangjiang

“…The advent of next-generation sequencing for genetic diagnoses of complex developmental disorders, such as intellectual disability (ID), has facilitated the…”
Get full text

Genomic data mining for functional annotation of human long noncoding RNAs by Gudenas, Brian L., Wang, Jun, Kuang, Shu-zhen, Wei, An-qi, Cogill, Steven B., Wang, Liang-jiang

“…Life may have begun in an RNA world, which is supported by increasing evidence of the vital role that RNAs perform in biological systems. In the human genome,…”
Get full text

A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor by Inoue, Akira, Janke, Laura J, Gudenas, Brian L, Jin, Hongjian, Fan, Yiping, Paré, Joshua, Clay, Michael R, Northcott, Paul A, Hirbe, Angela C, Cao, Xinwei

“…Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas. Somatic inactivation of and cooperating tumor suppressors, including , PRC2, and p53,…”
Get full text

MDB-52. MYC-DRIVEN PEDIATRIC BRAIN TUMORS SHARE A COMMON PHOTORECEPTOR IDENTITY by Zhao, Miao, Rosén, Gabriela, Sundstrom, Anders, Olsen, Thale Kristin, Furukawa, Takahisa, Gudenas, Brian L, Northcott, Paul A, Swartling, Fredrik J

“…Mouse models serve as invaluable tools for improving the understanding and treatment of pediatric brain tumors. We recently published a highly aggressive…”
Get full text

MDB-32. PRDM6 PROMOTES MEDULLOBLASTOMA FORMATION IN NEUROEPITHELIAL STEM CELLS AND IS A CHROMATIN REPRESSOR BY BINDING TO HISTONE H3 LYSINE 27 TRIMETHYLATION MARKS by Schmidt, Christin, Cohen, Sarah, Gudenas, Brian L, Husain, Sarah, Carlson, Annika, Westelman, Samantha, Wang, Linyu, Phillips, Joanna J, Northcott, Paul A, Weiss, William A, Schwer, Bjoern

“…A substantial fraction of Group 4 MBs are characterized by enhancer hijacking through tandem duplication of SNCAIP, resulting in high expression of PRDM6, a…”
Get full text

Germline Elongator mutations in Sonic Hedgehog medulloblastoma by Waszak, Sebastian M., Robinson, Giles W, Gudenas, Brian L., Smith, Kyle S., Forget, Antoine, Kojic, Marija, Garcia-Lopez, Jesus, Hadley, Jennifer, Hamilton, Kayla V., Indersie, Emilie, Buchhalter, Ivo, Kerssemakers, Jules, Jäger, Natalie, Sharma, Tanvi, Rausch, Tobias, Kool, Marcel, Sturm, Dominik, Jones, David T. W., Vasilyeva, Aksana, Tatevossian, Ruth G., Neale, Geoffrey, Lombard, Bérangère, Loew, Damarys, Nakitandwe, Joy, Rusch, Michael, Bowers, Daniel C., Bendel, Anne, Partap, Sonia, Chintagumpala, Murali, Crawford, John, Gottardo, Nicholas G., Smith, Amy, Dufour, Christelle, Rutkowski, Stefan, Eggen, Tone, Wesenberg, Finn, Kjaerheim, Kristina, Feychting, Maria, Lannering, Birgitta, Schüz, Joachim, Johansen, Christoffer, Andersen, Tina V., Röösli, Martin, Kuehni, Claudia E., Grotzer, Michael, Remke, Marc, Puget, Stéphanie, Pajtler, Kristian W., Milde, Till, Witt, Olaf, Ryzhova, Marina, Korshunov, Andrey, Orr, Brent A., Ellison, David W., Brugieres, Laurence, Lichter, Peter, Nichols, Kim E., Gajjar, Amar, Wainwright, Brandon J., Ayrault, Olivier, Korbel, Jan O., Northcott, Paul A., Pfister, Stefan M.

“…Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare…”
Get full text

MDB-59. INTEGRATIVE PROTEO-GENOMICS TO DECIPHER MOLECULAR MECHANISMS UNDERLYING SUBGROUP-SPECIFIC HETEROGENEITY IN MEDULLOBLASTOMA by Li, Yiran, Gudenas, Brian L, Smith, Kyle S, Lin, Hong, North, Kelsey C, Soliman, Taha, Hadley, Jennifer, Batts, Melissa, Dhanda, Sandeep K, Atkinson, Natasha, Mercer, Kimberly S, High, Anthony, Yuan, Zuo-Fei, Wang, Xusheng, Peng, Junmin, Roussel, Martine F, Robinson, Giles W, Orr, Brent A, Northcott, Paul A

Get full text

Gene Coexpression Networks in Human Brain Developmental Transcriptomes Implicate the Association of Long Noncoding RNAs with Intellectual Disability by Brian L Gudenas, Liangjiang Wang

“…The advent of next-generation sequencing for genetic diagnoses of complex developmental disorders, such as intellectual disability (ID), has facilitated the…”
Get full text

MBCL-21. GERMLINE ELONGATOR MUTATIONS IN SONIC HEDGEHOG MEDULLOBLASTOMA by Robinson, Giles W, Waszak, Sebastian M, Gudenas, Brian L, Smith, Kyle S, Forget, Antoine, Kojic, Marija, Jesus, Garcia-Lopez, Hadley, Jennifer, Hamilton, Kayla V, Indersie, Emilie, Buchhalter, Ivo, Jager, Natalie, Sharma, Tanvi, Rausch, Tobias, Kool, Marcel, Sturm, Dominic, Jones, David T W, Tatevossian, Ruth, Lombard, Berangere, Loew, Damarys, Bowers, Daniel, Bendel, Anne, Partap, Sonia, Chintagumpala, Murali, Crawford, John, Gottardo, Nicholas G, Smith, Amy, Dufour, Christelle, Rutkowski, Stefan, Grotzer, Michael, Remke, Mark, Puget, Stephanie, Pajtler, Kristian W, Milde, Till, Witt, Olaf, Ryzhova, Marina, Korshunov, Andrey, Orr, Brent A, Ellison, David W, Brugieres, Laurence, Lichter, Peter, Nichols, Kim E, Gajjar, Amar, Wainwright, Brandon J, Ayrault, Olivier, Korbel, Jan O, Northcott, Paul A, Pfister, Stefan M

“…Abstract BACKGROUND Our previous analysis of established cancer predisposition genes in medulloblastoma (MB) identified pathogenic germline variants in ~5% of…”
Get full text

Genomic Data Mining for Functional Annotation of Human Long Noncoding RNAs by Gudenas, Brian L

“…Life may have begun in an RNA world, which is supported by the increasingly vital role that RNA has been shown to perform in biological systems. To understand…”
Get full text