Search Results - "Gude, Natalie A"

Enhancing myocardial repair with CardioClusters by Monsanto, Megan M., Wang, Bingyan J., Ehrenberg, Zach R., Echeagaray, Oscar, White, Kevin S., Alvarez, Roberto, Fisher, Kristina, Sengphanith, Sharon, Muliono, Alvin, Gude, Natalie A., Sussman, Mark A.

“…Cellular therapy to treat heart failure is an ongoing focus of intense research, but progress toward structural and functional recovery remains modest…”
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Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI) by Alvarez, Roberto, Wang, Bingyan J., Quijada, Pearl J., Avitabile, Daniele, Ho, Thi, Shaitrit, Maya, Chavarria, Monica, Firouzi, Fareheh, Ebeid, David, Monsanto, Megan M., Navarrete, Natalie, Moshref, Maryam, Siddiqi, Sailay, Broughton, Kathleen M., Bailey, Barbara A., Gude, Natalie A., Sussman, Mark A.

“…Understanding and manipulating the cardiomyocyte cell cycle has been the focus of decades of research, however the ultimate goal of activating mitotic activity…”
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Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase by FISCHER, Kimberlee M, COTTAGE, Christopher T, WEITAO WU, SHABANA DIN, GUDE, Natalie A, AVITABILE, Daniele, QUIJADA, Pearl, COLLINS, Brett L, FRANSIOLI, Jenna, SUSSMAN, Mark A

“…Despite numerous studies demonstrating the efficacy of cellular adoptive transfer for therapeutic myocardial regeneration, problems remain for donated cells…”
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Cardiac Stem Cell Hybrids Enhance Myocardial Repair by Quijada, Pearl, Salunga, Hazel T, Hariharan, Nirmala, Cubillo, Jonathan D, El-Sayed, Farid G, Moshref, Maryam, Bala, Kristin M, Emathinger, Jacqueline M, De La Torre, Andrea, Ormachea, Lucia, Alvarez, Roberto, Gude, Natalie A, Sussman, Mark A

“…RATIONALE:Dual cell transplantation of cardiac progenitor cells (CPCs) and mesenchymal stem cells (MSCs) after infarction improves myocardial repair and…”
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Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice by CHENGQUN HUANG, XIAOXUE ZHANG, GUSTAFSSON, Asa B, RAMIL, Jennifer M, RIKKA, Shivaji, KIM, Lucy, LEE, Youngil, GUDE, Natalie A, THISTLETHWAITE, Patricia A, SUSSMAN, Mark A, GOTTLIEB, Roberta A

“…The anthracycline doxorubicin is an effective chemotherapeutic agent used to treat pediatric cancers but is associated with cardiotoxicity that can manifest…”
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Activation of Notch-Mediated Protective Signaling in the Myocardium by Gude, Natalie A, Emmanuel, Gregory, Wu, Weitao, Cottage, Christopher T, Fischer, Kimberlee, Quijada, Pearl, Muraski, John A, Alvarez, Roberto, Rubio, Marta, Schaefer, Eric, Sussman, Mark A

“…The Notch network regulates multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and…”
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Sca-1 Knockout Impairs Myocardial and Cardiac Progenitor Cell Function by Bailey, Brandi, Fransioli, Jenna, Gude, Natalie A, Alvarez, Roberto, Zhan, Xiaoxue, Gustafsson, Åsa B, Sussman, Mark A

“…RATIONALE:Cardiac progenitor cells are important for maintenance of myocardial structure and function, but molecular mechanisms governing these progenitor…”
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Regulation of Cardiac Hypertrophic Signaling by Prolyl Isomerase Pin1 by Toko, Haruhiro, Konstandin, Mathias H, Doroudgar, Shirin, Ormachea, Lucia, Joyo, Eri, Joyo, Anya Y, Din, Shabana, Gude, Natalie A, Collins, Brett, Völkers, Mirko, Thuerauf, Donna J, Glembotski, Christopher C, Chen, Chun-Hau, Lu, Kun Ping, Müller, Oliver J, Uchida, Takafumi, Sussman, Mark A

“…RATIONALE:Cardiac hypertrophy results from the complex interplay of differentially regulated cascades based on the phosphorylation status of involved signaling…”
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Evolution of the c‐kit‐Positive Cell Response to Pathological Challenge in the Myocardium by Fransioli, Jenna, Bailey, Brandi, Gude, Natalie A., Cottage, Christopher T., Muraski, John A., Emmanuel, Gregory, Wu, Weitao, Alvarez, Roberto, Rubio, Marta, Ottolenghi, Sergio, Schaefer, Erik, Sussman, Mark A.

“…Cumulative evidence indicates that myocardium responds to growth or injury by recruitment of stem and/or progenitor cells that participate in repair and…”
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Differential Regulation of Cellular Senescence and Differentiation by Prolyl Isomerase Pin1 in Cardiac Progenitor Cells by Toko, Haruhiro, Hariharan, Nirmala, Konstandin, Mathias H., Ormachea, Lucia, McGregor, Michael, Gude, Natalie A., Sundararaman, Balaji, Joyo, Eri, Joyo, Anya Y., Collins, Brett, Din, Shabana, Mohsin, Sadia, Uchida, Takafumi, Sussman, Mark A.

“…Autologous c-kit+ cardiac progenitor cells (CPCs) are currently used in the clinic to treat heart disease. CPC-based regeneration may be further augmented by…”
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PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression by Ebeid, David E, Firouzi, Fareheh, Esquer, Carolina Y, Navarrete, Julian M, Wang, Bingyan J, Gude, Natalie A, Sussman, Mark A

“…Enhancing cardiomyocyte survival is crucial to blunt deterioration of myocardial structure and function following pathological damage. PIM1 (Proviral Insertion…”
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Preservation of Myocardial Structure Is Enhanced by Pim-1 Engineering of Bone Marrow Cells by Quijada, Pearl, Toko, Haruhiro, Fischer, Kimberlee M, Bailey, Brandi, Reilly, Patrick, Hunt, Kristin D, Gude, Natalie A, Avitabile, Daniele, Sussman, Mark A

“…RATIONALE:Bone marrow–derived cells to treat myocardial injury improve cardiac function and support beneficial cardiac remodeling. However, survival of stem…”
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Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence by Gude, Natalie A., Broughton, Kathleen M., Firouzi, Fareheh, Sussman, Mark A.

“…Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular level, ageing entails decreased replicative capacity and…”
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Neural Stem Cell Depletion and CNS Developmental Defects After Enteroviral Infection by Ruller, Chelsea M, Tabor-Godwin, Jenna M, Van Deren, Donn A, Robinson, Scott M, Maciejewski, Sonia, Gluhm, Shea, Gilbert, Paul E, An, Naili, Gude, Natalie A, Sussman, Mark A, Whitton, J. Lindsay, Feuer, Ralph

“…Coxsackieviruses are significant human pathogens causing myocarditis, meningitis, and encephalitis. We previously demonstrated the ability of coxsackievirus B3…”
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Cardiac regenerative therapy: Many paths to repair by Gude, Natalie A., Sussman, Mark A.

“…Cardiovascular disease remains the primary cause of death in the United States and in most nations worldwide, despite ongoing intensive efforts to promote…”
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Chasing c-Kit through the heart: Taking a broader view by Gude, Natalie A., Sussman, Mark A.

“…[Display omitted] Stem cell mediated cardiac repair is an exciting and controversial area of cardiovascular research that holds the potential to produce novel,…”
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‘Youthful’ phenotype of c-Kit+ cardiac fibroblasts by Firouzi, Fareheh, Echeagaray, Oscar, Esquer, Carolina, Gude, Natalie A., Sussman, Mark A.

“…Cardiac fibroblast (CF) population heterogeneity and plasticity present a challenge for categorization of biological and functional properties. Distinct…”
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Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling by Ebeid, David E, Khalafalla, Farid G, Broughton, Kathleen M, Monsanto, Megan M, Esquer, Carolina Y, Sacchi, Veronica, Hariharan, Nirmala, Korski, Kelli I, Moshref, Maryam, Emathinger, Jacqueline, Cottage, Christopher T, Quijada, Pearl J, Nguyen, Jonathan H, Alvarez, Roberto, Völkers, Mirko, Konstandin, Mathias H, Wang, Bingyan J, Firouzi, Fareheh, Navarrete, Julian M, Gude, Natalie A, Goumans, Marie-Jose, Sussman, Mark A

“…Abstract Aims Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic…”
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Cardiac c-Kit Biology Revealed by Inducible Transgenesis by Gude, Natalie A, Firouzi, Fareheh, Broughton, Kathleen M, Ilves, Kelli, Nguyen, Kristine P, Payne, Christina R, Sacchi, Veronica, Monsanto, Megan M, Casillas, Alexandria R, Khalafalla, Farid G, Wang, Bingyan J, Ebeid, David E, Alvarez, Roberto, Dembitsky, Walter P, Bailey, Barbara A, van Berlo, Jop, Sussman, Mark A

“…RATIONALE:Biological significance of c-Kit as a cardiac stem cell marker and role(s) of c-Kit+ cells in myocardial development or response to pathological…”
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A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS by Tabor-Godwin, Jenna M, Ruller, Chelsea M, Bagalso, Nolan, An, Naili, Pagarigan, Robb R, Harkins, Stephanie, Gilbert, Paul E, Kiosses, William B, Gude, Natalie A, Cornell, Christopher T, Doran, Kelly S, Sussman, Mark A, Whitton, J Lindsay, Feuer, Ralph

“…Enterovirus infection in newborn infants is a significant cause of aseptic meningitis and encephalitis. Using a neonatal mouse model, we previously determined…”
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