Search Results - "Guddat, Luke"

Acetohydroxyacid synthase: a target for antimicrobial drug discovery by Pue, Nason, Guddat, Luke W

“…Acetohydroxyacid synthase (AHAS) (EC 2.2.1.6) (also known as acetolactate synthase) is the first common enzyme in the branched chain amino acid (BCAA)…”
Get more information

Structure of the RNA-dependent RNA polymerase from COVID-19 virus by Gao, Yan, Yan, Liming, Huang, Yucen, Liu, Fengjiang, Zhao, Yao, Cao, Lin, Wang, Tao, Sun, Qianqian, Ming, Zhenhua, Zhang, Lianqi, Ge, Ji, Zheng, Litao, Zhang, Ying, Wang, Haofeng, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Hua, Tian, Zhang, Bing, Yang, Xiuna, Li, Jun, Yang, Haitao, Liu, Zhijie, Xu, Wenqing, Guddat, Luke W, Wang, Quan, Lou, Zhiyong, Rao, Zihe

“…A novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] outbreak has caused a global coronavirus disease 2019 (COVID-19) pandemic,…”
Get full text

Structure of M pro from SARS-CoV-2 and discovery of its inhibitors by Jin, Zhenming, Du, Xiaoyu, Xu, Yechun, Deng, Yongqiang, Liu, Meiqin, Zhao, Yao, Zhang, Bing, Li, Xiaofeng, Zhang, Leike, Peng, Chao, Duan, Yinkai, Yu, Jing, Wang, Lin, Yang, Kailin, Liu, Fengjiang, Jiang, Rendi, Yang, Xinglou, You, Tian, Liu, Xiaoce, Yang, Xiuna, Bai, Fang, Liu, Hong, Liu, Xiang, Guddat, Luke W, Xu, Wenqing, Xiao, Gengfu, Qin, Chengfeng, Shi, Zhengli, Jiang, Hualiang, Rao, Zihe, Yang, Haitao

“…A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019-2020 viral…”
Get full text

Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase by Wang, Quan, Wu, Jiqin, Wang, Haofeng, Gao, Yan, Liu, Qiaojie, Mu, An, Ji, Wenxin, Yan, Liming, Zhu, Yan, Zhu, Chen, Fang, Xiang, Yang, Xiaobao, Huang, Yucen, Gao, Hailong, Liu, Fengjiang, Ge, Ji, Sun, Qianqian, Yang, Xiuna, Xu, Wenqing, Liu, Zhijie, Yang, Haitao, Lou, Zhiyong, Jiang, Biao, Guddat, Luke W., Gong, Peng, Rao, Zihe

“…Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19…”
Get full text

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur by Jin, Zhenming, Zhao, Yao, Sun, Yuan, Zhang, Bing, Wang, Haofeng, Wu, Yan, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Du, Xiaoyu, Duan, Yinkai, Yu, Jing, Yang, Xiaobao, Yang, Xiuna, Yang, Kailin, Liu, Xiang, Guddat, Luke W., Xiao, Gengfu, Zhang, Leike, Yang, Haitao, Rao, Zihe

“…The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (M pro ). Here, the X-ray crystal structure of M pro in complex with carmofur…”
Get full text

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis by Yan, Liming, Ge, Ji, Zheng, Litao, Zhang, Ying, Gao, Yan, Wang, Tao, Huang, Yucen, Yang, Yunxiang, Gao, Shan, Li, Mingyu, Liu, Zhenyu, Wang, Haofeng, Li, Yingjian, Chen, Yu, Guddat, Luke W., Wang, Quan, Rao, Zihe, Lou, Zhiyong

“…Transcription of SARS-CoV-2 mRNA requires sequential reactions facilitated by the replication and transcription complex (RTC). Here, we present a structural…”
Get full text

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target by Zhang, Bing, Li, Jun, Yang, Xiaolin, Wu, Lijie, Zhang, Jia, Yang, Yang, Zhao, Yao, Zhang, Lu, Yang, Xiuna, Yang, Xiaobao, Cheng, Xi, Liu, Zhijie, Jiang, Biao, Jiang, Hualiang, Guddat, Luke W., Yang, Haitao, Rao, Zihe

“…Despite intensive efforts to discover highly effective treatments to eradicate tuberculosis (TB), it remains as a major threat to global human health. For this…”
Get full text

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2 by Zhao, Yao, Zhu, Yan, Liu, Xiang, Jin, Zhenming, Duan, Yinkai, Zhang, Qi, Wu, Chengyao, Feng, Lu, Du, Xiaoyu, Zhao, Jinyi, Shao, Maolin, Zhang, Bing, Yang, Xiuna, Wu, Lijie, Ji, Xiaoyun, Guddat, Luke W, Yang, Kailin, Rao, Zihe, Yang, Haitao

“…The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key enzyme, which extensively digests CoV replicase polyproteins…”
Get full text

Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families by Garcia, Mario D., Nouwens, Amanda, Lonhienne, Thierry G., Guddat, Luke W.

“…Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which is the first enzyme in the branched-chain amino acid…”
Get full text

Crystal Structures of Arabidopsis thaliana Acetohydroxyacid Synthase in Complex with the Herbicide Triasulfuron and Two Analogues with Herbicidal Activity in Field Trials by Cheng, Yan, Wang, Yuan, Lonhienne, Thierry, Wang, Jian-Guo, Guddat, Luke W.

“…Triasulfuron is a commercial herbicide of the sulfonylurea family. This compound targets acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), the first enzyme in…”
Get full text

Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading by Yan, Liming, Yang, Yunxiang, Li, Mingyu, Zhang, Ying, Zheng, Litao, Ge, Ji, Huang, Yucen C., Liu, Zhenyu, Wang, Tao, Gao, Shan, Zhang, Ran, Huang, Yuanyun Y., Guddat, Luke W., Gao, Yan, Rao, Zihe, Lou, Zhiyong

“…The capping of mRNA and the proofreading play essential roles in SARS-CoV-2 replication and transcription. Here, we present the cryo-EM structure of the…”
Get full text

Structural insights into the mechanism of inhibition of AHAS by herbicides by Lonhienne, Thierry, Garcia, Mario D., Pierens, Gregory, Mobli, Mehdi, Nouwens, Amanda, Guddat, Luke W.

“…Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway, is present only in plants and microorganisms, and it is the…”
Get full text

Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO by Yang, Xiaolin, Hu, Tianyu, Yang, Xiuna, Xu, Wenqing, Yang, Haitao, Guddat, Luke W., Zhang, Bing, Rao, Zihe

“…Novel antitubercular agents are urgently needed to combat the emergence of global drug resistance to human tuberculosis. Mycobacterial membrane protein Large 3…”
Get full text

Structure of the human respiratory complex II by Du, Zhanqiang, Zhou, Xiaoting, Lai, Yuezheng, Xu, Jinxu, Zhang, Yuying, Zhou, Shan, Feng, Ziyan, Yu, Long, Tang, Yanting, Wang, Weiwei, Yu, Lu, Tian, Changlin, Ran, Ting, Chen, Hongming, Guddat, Luke W, Liu, Fengjiang, Gao, Yan, Rao, Zihe, Gong, Hongri

“…Human complex II is a key protein complex that links two essential energy-producing processes: the tricarboxylic acid cycle and oxidative phosphorylation…”
Get full text

Structure of the human ATP synthase by Lai, Yuezheng, Zhang, Yuying, Zhou, Shan, Xu, Jinxu, Du, Zhanqiang, Feng, Ziyan, Yu, Long, Zhao, Ziqing, Wang, Weiwei, Tang, Yanting, Yang, Xiuna, Guddat, Luke W., Liu, Fengjiang, Gao, Yan, Rao, Zihe, Gong, Hongri

“…Biological energy currency ATP is produced by F1Fo-ATP synthase. However, the molecular mechanism for human ATP synthase action remains unknown. Here, we…”
Get full text

An electron transfer path connects subunits of a mycobacterial respiratory supercomplex by Gong, Hongri, Li, Jun, Xu, Ao, Tang, Yanting, Ji, Wenxin, Gao, Ruogu, Wang, Shuhui, Yu, Lu, Tian, Changlin, Li, Jingwen, Yen, Hsin-Yung, Man Lam, Sin, Shui, Guanghou, Yang, Xiuna, Sun, Yuna, Li, Xuemei, Jia, Minze, Yang, Cheng, Jiang, Biao, Lou, Zhiyong, Robinson, Carol V, Wong, Luet-Lok, Guddat, Luke W, Sun, Fei, Wang, Quan, Rao, Zihe

“…We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from It comprises a complex III dimer flanked on…”
Get full text

Discovery and evaluation of novel Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors as therapeutic drug leads by Krishna, Vagolu Siva, Zheng, Shan, Rekha, Estharla Madhu, Guddat, Luke W., Sriram, Dharmarajan

“…Tuberculosis (TB) remains a major threat to human health. This due to the fact that current drug treatments are less than optimal and the increasing occurrence…”
Get full text

High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors by Zhao, Yao, Du, Xiaoyu, Duan, Yinkai, Pan, Xiaoyan, Sun, Yifang, You, Tian, Han, Lin, Jin, Zhenming, Shang, Weijuan, Yu, Jing, Guo, Hangtian, Liu, Qianying, Wu, Yan, Peng, Chao, Wang, Jun, Zhu, Chenghao, Yang, Xiuna, Yang, Kailin, Lei, Ying, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Sun, Lei, Zhang, Leike, Rao, Zihe, Yang, Haitao

“…A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-19 outbreak. Currently, effective treatment options remain very limited…”
Get full text

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol by Zhang, Lu, Zhao, Yao, Gao, Yan, Wu, Lijie, Gao, Ruogu, Zhang, Qi, Wang, Yinan, Wu, Chengyao, Wu, Fangyu, Gurcha, Sudagar S, Veerapen, Natacha, Batt, Sarah M, Zhao, Wei, Qin, Ling, Yang, Xiuna, Wang, Manfu, Zhu, Yan, Zhang, Bing, Bi, Lijun, Zhang, Xian'en, Yang, Haitao, Guddat, Luke W, Xu, Wenqing, Wang, Quan, Li, Jun, Besra, Gurdyal S, Rao, Zihe

“…The arabinosyltransferases EmbA, EmbB, and EmbC are involved in cell wall synthesis and are recognized as targets for the anti-tuberculosis drug ethambutol. In…”
Get full text

Crystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase by Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard, Guddat, Luke W.

“…Amidosulfuron (AS) is from the commercial sulfonylurea herbicide family. It is highly effective against dicot broad-leaf weeds. This herbicide targets…”
Get full text