Search Results - "Gudas, Jean"

Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma by Huang, Suyun, Mills, Lisa, Mian, Badar, Tellez, Carmen, McCarty, Marya, Yang, X.-D., Gudas, Jean M., Bar-Eli, Menashe

“…Interleukin-8 (IL-8) has recently been shown to contribute to human melanoma progression by functioning as a mitogenic and angiogenic factor. In the present…”
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Abstract LB-188: Sensitivity of 89Zr-labeled anti-CD8 minibody for PET imaging of infiltrating CD8+ T cells by Olafsen, Tove, Jiang, Ziyue Karen, Romero, Jason, Zamilpa, Charles, Marchioni, Filippo, Zhang, Green, Torgov, Michael, Satpayev, Daulet, Gudas, Jean M.

“…Background- The ability to monitor CD8 positive tumor infiltrating lymphocytes (TILs) in vivo is important for evaluating response to immunotherapies and…”
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Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication In vitro and growth of human tumor xenografts In vivo by CHALLITA-EID, Pia M, MORRISON, Kendall, JAKOBOVITS, Aya, ETESSAMI, Soudabeh, ZILI AN, MORRISON, Karen J, PEREZ-VILLAR, Juan J, RAITANO, Arthur B, JIA, Xiao-Chi, GUDAS, Jean M, KANNER, Steven B

“…Six-transmembrane epithelial antigen of the prostate-1 (STEAP-1) is a novel cell surface protein highly expressed in primary prostate cancer, with restricted…”
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Fully Human Anti-Interleukin 8 Antibody Inhibits Tumor Growth in Orthotopic Bladder Cancer Xenografts via Down-Regulation of Matrix Metalloproteases and Nuclear Factor-κB by MIAN, Badar M, DINNEY, Colin P. N, BERMEJO, Carlos E, SWEENEY, Paul, TELLEZ, Carmen, YANG, X. D, GUDAS, Jean M, MCCONKEY, David J, BAR-ELI, Menashe

“…Purpose: We previously demonstrated that overexpression of interleukin 8 (IL-8) in human transitional cell carcinoma (TCC) resulted in increased tumorigenicity…”
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Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma by MILLS, Lisa, TELLEZ, Carmen, SUYUN HUANG, BAKER, Cheryl, MCCARTY, Marya, GREEN, Larry, GUDAS, Jean M, FENG, X, BAR-ELI, Menashe

“…MCAM/MUC18 expression correlates with tumor thickness and metastatic potential of human melanoma cells in nude mice. Moreover, ectopic expression of MUC18 in…”
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Cyclin E2, a Novel G1 Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human Cancers by M. Gudas, Jean, Payton, Marc, Thukral, Sushil, Chen, Eddy, Bass, Michael, Robinson, Murray O., Coats, Steve

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation of the Quiescence-Induced Genes: Quiescin Q6, Decorin, and Ribosomal Protein S29 by Coppock, Donald, Kopman, Cynthia, Gudas, Jean, Cina-Poppe, Deborah A.

“…The transition from growth to quiescence is deeply deranged in cancer cells. Expression of the quiescence-induced genes, quiescin Q6, decorin, and S29, was…”
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Hormone-dependent regulation of BRCA1 in human breast cancer cells by GUDAS, J. M, HOANG NGUYEN, TAO LI, COWAN, K. H

“…BRCA1 mRNA and protein levels are regulated by the steroid hormones estrogen and progesterone in human breast cancer cells. BRCA1 mRNA and protein levels were…”
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Disruption of Cell Cycle Kinetics by Benzo[a]pyrene: Inverse Expression Patterns of BRCA-1 and p53 in MCF-7 Cells Arrested in S and G2 by Jeffy, Brandon D., Chen, Eddy J., Gudas, Jean M., Romagnolo, Donato F.

“…The effects of a ligand of the aromatic hydrocarbon receptor (AhR), benzo[a]pyrene(B[a]P), and its metabolite, BPDE…”
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Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: Requirements for metabolism of benzo[a]pyrene to 7r, 8t-dihydroxy-9t, 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene by JEFFY, Brandon D, CHIRNOMAS, Ryan B, CHEN, Eddy J, GUDAS, Jean M, ROMAGNOLO, Donato F

“…Reduction of BRCA-1 expression through nonmutational events may be a predisposing event in the onset of sporadic breast cancer. In this study, we investigated…”
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Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene ( RFC1) by Gong, Maokai, Cowan, Kenneth H., Gudas, Jean, Moscow, Jeffrey A.

“…Decreased reduced folate carrier (RFC) activity has been associated with MTX resistance in experimental models of transport-mediated MTX resistance, and has…”
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BRCA1 protein products: Antibody specificity by Wilson, Cindy A, Payton, Marc N, Pekar, Susan K, Zhang, Ke, Pacifici, Robert E, Gudas, Jean L, Thukral, Sushil, Calzone, Frank J, Reese, David M, Slamon, Dennis I

“…The recent publication of Chen et al. and Jensen et al. have generated conflicting views of BRCA1 protein kinesis that must be resolved before the functional…”
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First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy by Hamdy, Freddie C., Lamb, Alastair D., Tullis, Iain D. C., Verrill, Clare, Rombach, Ines, Rao, Srinivasa R., Colling, Richard, Barber, Paul R., Volpi, Davide, Barbera-Martin, Luis, Lopez, J Francisco, Omer, Altan, Hewitt, Aimi, Lovell, Shelagh, Niederer, Jane, Lambert, Adam, Snoeck, Joke, Thomson, Claire, Leslie, Tom, Bryant, Richard J., Mascioni, Alessandro, Jia, Fang, Torgov, Michael, Wilson, Ian, Gudas, Jean, Wu, Anna M., Olafsen, Tove, Vojnovic, Borivoj

“…Purpose Prostate-specific membrane antigen (PSMA) is increasingly used to image prostate cancer in clinical practice. We sought to develop and test a humanised…”
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P‐Glycoprotein Is Positively Correlated with p53 Protein Accumulation in Human Colorectal Cancers by Oka, Mikio, Kounoura, Kiyoshi, Narasaki, Fumihiko, Sakamoto, Akira, Fukuda, Minoru, Matsuo, Isao, Ikeda, Koki, Tsurutani, Junji, Ikuno, Nobuhiro, Omagari, Katsuhisa, Mizuta, Yohei, Soda, Hiroshi, Gudas, Jean M., Kohno, Shigeru

“…To explore the relationship between mutant p53 and Pgp expression, we have examined the levels of both proteins in human colorectal adenocarcinomas. Serial…”
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First in Human Phase I Imaging Study With 89Zr-IAB22M2C Anti CD8 Minibody in Patients with Solid Tumors by Pandit-Taskar, Neeta, Postow, Micheal, O'Donoghue, Joseph, Harding, James, Ziolkowska, Martha, Lyashchenko, Serge, Lewis, Jason, Wu, Anna, Le, William, Gudas, Jean, Korn, Ronald, Torgov, Michael, Wolchok, Jedd, Weber, Wolfgang

“…Objectives: Immune modulating agents are becoming the mainstay for treatment of a variety of malignancies, but only a subset of patients respond to…”
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Abstract 104: Preclinical microPET/CT imaging of 89Zr-Df-SGN-35 in mice bearing xenografted CD30 expressing and non-expressing tumors by Moss, Aaron, Gudas, Jean, Albertson, Tina, Whiting, Nancy, Law, Che-Leung

“…Introduction: Positron emission tomography (PET) imaging is a non-invasive tool to quantitatively describe the drug distribution in vivo. To answer the…”
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The PET-tracer 89Zr-Df-IAB22M2C enables monitoring of intratumoral CD8 T cell infiltrates in tumor-bearing humanized mice after T cell bispecific antibody treatment by Griessinger, Christoph M, Olafsen, Tove, Mascioni, Alessandro, Jiang, Ziyue Karen, Zamilpa, Charles, Jia, Fang, Torgov, Michael, Romero, Jason M, Marchioni, Filippo, Satpayev, Daulet, Lee, Chenyu, Zhang, Green, Nayak, Tapan K, Pincha, Mudita, Amann, Maria, Mohan, Preethi Latha Bhavani, Richard, Marine, Nicolini, Valeria G, Sam, Johannes, Claus, Christina, Ferrara, Claudia, Brünker, Peter, Bacac, Marina, Umana, Pablo, Rüttinger, Dominik, Wilson, Ian A, Gudas, Jean, Klein, Christian, Tessier, Jean J L

“…CD8-expressing T cells are the main effector cells in cancer immunotherapy (CIT). Treatment-induced changes in intratumoral CD8+ T cells may represent a…”
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Abstract LB-163: Development of an immunoPET tracer for imaging human CD8+ T cells by Olafsen, Tove, Ho, David, Epin, Eric, Zhang, Green, Torgov, Michael, Beigarten, Charlie, Agahi, Giti, Cabral, Edward, Wu, Anna M., Gudas, Jean M.

“…Background: Infiltration of CD8+ T cells into human tumors is associated with an increased disease-specific survival in many cancers. A better understanding of…”
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Wild Type p53 Stimulates Expression from the Human Multidrug Resistance Promoter in a p53-negative Cell Line (∗) by Goldsmith, Merrill E., Gudas, Jean M., Schneider, Erasmus, Cowan, Kenneth H.

“…The effect of human wild type and mutant p53 proteins on the human multidrug resistance (MDR1) promoter was studied in a p53-negative human cell line…”
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Minibody imaging of prostate-specific membrane antigen (PSMA): From concept to clinic by Olafsen, Tove, Bartlett, Derek, Ho, David, Zhang, Green, Torgov, Michael, Keppler, Jennifer, Behrenbruch, Christian, Wu, Anna, Pandit-Taskar, Neeta, Morris, Michael J., Lewis, Jason Stuart, Lyashchenko, Serge K., Gudas, Jean M.

“…Abstract only…”
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