Search Results - "Gubin, M M"

Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells by Fehlings, M., Simoni, Y., Penny, H. L., Becht, E., Loh, C. Y., Gubin, M. M., Ward, J. P., Wong, S. C., Schreiber, R. D., Newell, E. W.

“…The analysis of neoantigen-specific CD8 + T cells in tumour-bearing individuals is challenging due to the small pool of tumour antigen-specific T cells. Here…”
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Tumor neoantigens: building a framework for personalized cancer immunotherapy by Gubin, Matthew M, Artyomov, Maxim N, Mardis, Elaine R, Schreiber, Robert D

“…It is now well established that the immune system can recognize developing cancers and that therapeutic manipulation of immunity can induce tumor regression…”
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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression by Chang, Chih-Hao, Qiu, Jing, O’Sullivan, David, Buck, Michael D., Noguchi, Takuro, Curtis, Jonathan D., Chen, Qiongyu, Gindin, Mariel, Gubin, Matthew M., van der Windt, Gerritje J.W., Tonc, Elena, Schreiber, Robert D., Pearce, Edward J., Pearce, Erika L.

“…Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells…”
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TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy by Molgora, Martina, Esaulova, Ekaterina, Vermi, William, Hou, Jinchao, Chen, Yun, Luo, Jingqin, Brioschi, Simone, Bugatti, Mattia, Omodei, Andrea Salvatore, Ricci, Biancamaria, Fronick, Catrina, Panda, Santosh K., Takeuchi, Yoshiko, Gubin, Matthew M., Faccio, Roberta, Cella, Marina, Gilfillan, Susan, Unanue, Emil R., Artyomov, Maxim N., Schreiber, Robert D., Colonna, Marco

“…Checkpoint immunotherapy unleashes T cell control of tumors, but is undermined by immunosuppressive myeloid cells. TREM2 is a myeloid receptor that transmits…”
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The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer by Ward, Jeffrey P, Gubin, Matthew M, Schreiber, Robert D

“…Definitive experimental evidence from mouse cancer models and strong correlative clinical data gave rise to the Cancer Immunoediting concept that explains the…”
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High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy by Gubin, Matthew M., Esaulova, Ekaterina, Ward, Jeffrey P., Malkova, Olga N., Runci, Daniele, Wong, Pamela, Noguchi, Takuro, Arthur, Cora D., Meng, Wei, Alspach, Elise, Medrano, Ruan F.V., Fronick, Catrina, Fehlings, Michael, Newell, Evan W., Fulton, Robert S., Sheehan, Kathleen C.F., Oh, Stephen T., Schreiber, Robert D., Artyomov, Maxim N.

“…Although current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment…”
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Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape by Noguchi, Takuro, Ward, Jeffrey P, Gubin, Matthew M, Arthur, Cora D, Lee, Sang Hun, Hundal, Jasreet, Selby, Mark J, Graziano, Robert F, Mardis, Elaine R, Korman, Alan J, Schreiber, Robert D

“…Antibody blockade of programmed death-1 (PD-1) or its ligand, PD-L1, has led to unprecedented therapeutic responses in certain tumor-bearing individuals, but…”
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Author Correction: Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells by Fehlings, M., Simoni, Y., Penny, H. L., Becht, E., Loh, C. Y., Gubin, M. M., Ward, J. P., Wong, S. C., Schreiber, R. D., Newell, E. W.

“…The original version of this Article omitted a declaration from the competing interests statement, which should have included the following: ‘R.D.S. is a…”
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On the Laser Generation in Two-Dimensional Materials with Pumping by Quasitrapped Modes by Gubin, M. Yu, Shesterikov, A. V., Volkov, V. S., Prokhorov, A. V.

“…A model has been proposed to describe the laser generation of two-dimensional semiconductor films with near-field pumping by quasitrapped modes excited in…”
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Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis by Chen, Jing, Cascio, Jason, Magee, Joseph D, Techasintana, Patsharaporn, Gubin, Matthew M, Dahm, Garrett M, Calaluce, Robert, Yu, Shiguang, Atasoy, Ulus

“…IL-17 is a proinflammatory cytokine produced by activated Th17 cells and other immune cells. IL-17-producing Th17 cells are major contributors to chronic…”
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Photonic Microwave Oscillator with Reduced Phase Noise at Small Offsets from the Carrier Frequency by Shelkovnikov, A. S., Kireev, A. N., Tyurikov, D. A., Gubin, M. A.

“…We have developed a transportable laboratory sample of a photonic microwave oscillator (PMO) based on an optical frequency standard (He–Ne/CH 4 laser, λ = 3.39…”
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Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy by Keshari, Sunita, Shavkunov, Alexander S., Miao, Qi, Saha, Akata, Minowa, Tomoyuki, Molgora, Martina, Williams, Charmelle D., Chaib, Mehdi, Highsmith, Anna M., Pineda, Josué E., Alekseev, Sayan, Alspach, Elise, Hu, Kenneth H., Colonna, Marco, Pauken, Kristen E., Chen, Ken, Gubin, Matthew M.

“…The goal of therapeutic cancer vaccines and immune checkpoint therapy (ICT) is to promote T cells with anti-tumor capabilities. Here, we compared mutant…”
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Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells by Techasintana, Patsharaporn, Davis, J Wade, Gubin, Matthew M, Magee, Joseph D, Atasoy, Ulus

“…Due to poor correlation between steady state mRNA levels and protein product, purely transcriptomic profiling methods may miss genes posttranscriptionally…”
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Formation of Nonclassical Optical States in Spaser Systems Controlled by an External Magnetic Field by Gubin, M. Yu, Prokhorov, A. V.

“…The quantum statistical and correlation properties of photons generated in a multiparticle spaser are investigated. A model of an effective subwavelength…”
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Switching Effects in Plasmonic Circuits Based on Thin Metal Films and Nanostructures with High Photoconductivity by Gubin, M. Yu, Dzedolik, I. V., Prokhorova, T. V., Pereskokov, V. S., Leksin, A. Yu

“…Specific features of optical control of propagation of surface plasmon polaritons in plasmonic circuits based on thin metal waveguides and semiconductor…”
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Intensity Noise and Pulse Repetition Frequency Stability Measurements of a Passive Mode-Locked Cr:ZnSe Laser by Leonov, S. O., Frolov, M. P., Korostelin, Yu. V., Skasyrsky, Ya. K., Fjodorow, P. Yu, Shelkovnikov, A. S., Kozlovsky, V. I., Kireev, A. N., Gubin, M. A.

“…The results on intensity noise and repetition frequency stability measurements for a passively mode-locked Cr:ZnSe laser pumped by a thulium-doped fiber laser…”
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Elucidating immune-related gene transcriptional programs via factorization of large-scale RNA-profiles by He, Shan, Gubin, Matthew M., Rafei, Hind, Basar, Rafet, Dede, Merve, Jiang, Xianli, Liang, Qingnan, Tan, Yukun, Kim, Kunhee, Gillison, Maura L., Rezvani, Katayoun, Peng, Weiyi, Haymaker, Cara, Hernandez, Sharia, Solis, Luisa M., Mohanty, Vakul, Chen, Ken

“…Recent developments in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy (ACT), have encountered challenges such as…”
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New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape by Mittal, Deepak, Gubin, Matthew M, Schreiber, Robert D, Smyth, Mark J

“…Highlights • Genomics analyses to identify the targets of cancer immunoediting and design personalized cancer immunotherapy. • Emerging role of innate immune…”
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The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer by Calaluce, Robert, Gubin, Matthew M, Davis, J Wade, Magee, Joseph D, Chen, Jing, Kuwano, Yuki, Gorospe, Myriam, Atasoy, Ulus

“…The discordance between steady-state levels of mRNAs and protein has been attributed to posttranscriptional control mechanisms affecting mRNA stability and…”
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Cancer Immunoediting in the Era of Immuno-oncology by Gubin, Matthew M, Vesely, Matthew D

“…Basic science breakthroughs in T-cell biology and immune-tumor cell interactions ushered in a new era of cancer immunotherapy. Twenty years ago, cancer…”
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