Search Results - "Gubernator, K"

Refined crystal structure of β-lactamase from Citrobacter freundii indicates a mechanism for β-lactam hydrolysis by Oefner, C, D'Arcy, A, Daly, J. J, Gubernator, K, Charnas, R. L, Heinze, I, Hubschwerlen, C, Winkler, F. K

“…Beta-Lactamases (EC 3.5.2.6, 'penicillinases') are a family of enzymes that protect bacteria against the lethal effects of cell-wall synthesis of penicillins,…”
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Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes by Kansy, Manfred, Senner, Frank, Gubernator, Klaus

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Amino acid substitution (IIe194 → Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands : support for a multicentric origin by HENDERSON, H. E, MA, Y, HASSAN, M. F, MONSALVE, M. V, MARAIS, A. D, WINKLER, F, GUBERNATOR, K, PETERSON, J, BRUNZELL, J. D, HAYDEN, M. R

“…Studies on the molecular biology of lipoprotein lipase (LPL) deficiency have been facilitated by the availability of LPL gene probes and the recent…”
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Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors by Hubschwerlen, C, Pflieger, P, Specklin, J. L, Gubernator, K, Gmuender, H, Angehrn, P, Kompis, I

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The Development of Potent and Highly Selective Thrombin Inhibitors by Hilpert, Kurt, Ackermann, Jean, Banner, David W., Gast, Alain, Gubernator, Klaus, Schmid, Gérard, Tschopp, Thomas B., van de Waterbeemd, Han

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Comment on the purported photoelectron spectrum of 1,2-dimethyl-3,4-dimethylenecyclobutene dimer by Gubernator, K, Spanget-Larsen, J, Gleiter, R, Hopf, H

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Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors by Hilpert, Kurt, Ackermann, Jean, Banner, David W., Gast, Alain, Gubernator, Klaus, Hadvary, Paul, Labler, Ludvik, Mueller, Klaus, Schmid, Gerard

“…Thrombin, a serine protease, plays a central role in the initiation and propagation of thrombotic events. An extensive search for new thrombin inhibitors was…”
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Structural databases and computer modeling in pharmaceutical research by Mueller, K, Ammann, H J, Doran, D M, Gerber, P R, Gubernator, K, Schrepfer, G

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Structure-Based Design of β-Lactamase Inhibitors. 1. Synthesis and Evaluation of Bridged Monobactams by Heinze-Krauss, Ingrid, Angehrn, Peter, Charnas, Robert L, Gubernator, Klaus, Gutknecht, Eva-Maria, Hubschwerlen, Christian, Kania, Malgosia, Oefner, Christian, Page, Malcolm G. P, Sogabe, Satoshi, Specklin, Jean-Luc, Winkler, Fritz

“…Bridged monobactams are novel, potent, mechanism-based inhibitors of class C β-lactamases, designed using X-ray crystal structures of the enzymes. They…”
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6-Guanidinopyranoses: Novel Carbohydrate-Based Peptidomimetics by Wessel, Hans Peter, Banner, David, Gubernator, Klaus, Hilpert, Kurt, Müller, Klaus, Tschopp, Thomas

“…The position of the carbohydrate derivative 1 in the recognition pocket of thrombin has been determined by X‐ray structure analysis of the inhibitor/thrombin…”
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Structure-Based Design of β-Lactamase Inhibitors. 2. Synthesis and Evaluation of Bridged Sulfactams and Oxamazins by Hubschwerlen, Christian, Angehrn, Peter, Gubernator, Klaus, Page, Malcolm G. P, Specklin, Jean-Luc

“…A series of bridged monocyclic β-lactams activated by various groups on the β-lactam nitrogen (X = OCH2CO2H, OSO3H) has been synthesized and evaluated. Among…”
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Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors by Hubschwerlen, C, Pflieger, P, Specklin, J L, Gubernator, K, Gmünder, H, Angehrn, P, Kompis, I

“…Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial…”
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The construction of new proteins: V. A template-assembled synthetic protein (TASP) containing both a 4-helix bundle and beta-barrel-like structure by Mutter, M, Hersperger, R, Gubernator, K, Müller, K

“…The construction of a template-assembled synthetic protein (TASP) designed to contain both a 4-helix bundle and a beta-barrel as two folding "domains" is…”
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Refined Crystal Structure of (Beta)-Lactamase from Citrobacter Freundii Indicates a Mechanism for (Beta)-Lactam Hydrolysis by Oefner, C, D Arcy, A, Daly, J J, Gubernator, K, Charnas, R L

“…Beta-Lactamases (EC 3.5.2.6, 'penicillinases') are a family of enzymes that protect bacteria against the lethal effects of cell-wall synthesis of penicillins,…”
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Refined crystal structure of β-lactamase from Citrobacter freundiiindicates a mechanism for β-lactam hydrolysis by Oefner, C., D'Arcy, A., Daly, J. J., Gubernator, K., Charnas, R. L., Heinze, I., Hubschwerlen, C., Winkler, F. K.

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Amino acid substitution (Ile super(194) arrow right Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands: Support for a multicentric origin by Henderson, HE, Ma, Y, Hassan, M F, Monsalve, M V, Marais, AD, Winkler, F, Gubernator, K, Peterson, J, Brunzell, J D, Hayden, M R

“…Studies on the molecular biology of lipoprotein lipase (LPL) deficiency have been facilitated by the availability of LPL gene probes and the recent…”
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2,3-Bis(methylene)bicyclo[2.1.1]hexane and 3,4-bis(methylene)tricyclo[3.1.0.02,6]hexane. Interaction between a .pi. system and a cyclobutane or bicyclobutane moiety by Gleiter, Rolf, Bischof, Peter, Gubernator, Klaus, Christl, Manfred, Schwager, Luis, Vogel, Pierre

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A new generation of anticoagulants: design, synthesis and pharmacologic profile of thrombin inhibtors by Schmid, G, Ackermann, J, Banner, D, Gast, A, Gubernator, K, Hadváry, P, Hilpert, K, Labler, L, Tschopp, T

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