Radioguided-surgery of early breast lesions

Radioguided-surgery of early breast lesions

Radioguided-surgery has been recently proposed in patients with clinically occult breast lesions. This study aimed to evaluate the feasibility of correctly locating and eradicating, by a single intralesional injection of a radiotracer, any breast lesion and, in the case of malignancy, to perform sim...

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Bibliographic Details
Published in:Anticancer research Vol. 21; no. 3C; p. 2091
Main Authors: Buonomo, O, Cabassi, A, Guadagni, F, Piazza, A, Felici, A, Piccirillo, R, Atzei, G P, Cipriani, C, Schiaroli, S, Mariotti, S, Guazzaroni, M N, Cossu, E, Simonetti, G, Pernazza, E, Casciani, C U, Roselli, M
Format: Journal Article
Language:English
Published: Greece 01-05-2001
Subjects:
Adult
Aged
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - surgery
Female
Humans
Injections, Intralesional
Lymph Nodes - surgery
Mastectomy, Segmental - methods
Middle Aged
Radionuclide Imaging
Radiopharmaceuticals - therapeutic use
Sentinel Lymph Node Biopsy
Technetium Tc 99m Aggregated Albumin - therapeutic use
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Summary:Radioguided-surgery has been recently proposed in patients with clinically occult breast lesions. This study aimed to evaluate the feasibility of correctly locating and eradicating, by a single intralesional injection of a radiotracer, any breast lesion and, in the case of malignancy, to perform simultaneous sentinel lymph node (SLN) biopsy procedure. Sixty-three women with early breast lesions were enrolled: 42 were invasive carcinomas, 16 in situ ductal carcinomas (DCIS) and 5 fibroadenomas. Scintigraphic images clearly identified the lesions in all patients while SLN/s were evident in 88% of them. At surgery all the breast lesions were easily radiolocalized and eradicated with minimum surgical trauma and, for those patients with invasive carcinomas, the SLN technique was performed in 86% of them. No skip metastases were found. A single intralesional administration of radiotracer is an easy and reliable procedure to simultaneously locate and remove both the non-palpable breast lesion and the SLN when primary malignancy was intraoperatively confirmed.
ISSN:0250-7005