Search Results - "Guarente, L"

Sirtuins in aging and disease by Guarente, L

“…Sirtuin genes function as anti-aging genes in yeast, Caenorhabditis elegans, and Drosophila. The NAD requirement for sirtuin function indicates a link between…”
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SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production by Bell, E L, Emerling, B M, Ricoult, S J H, Guarente, L

“…It has become increasing clear that alterations in cellular metabolism have a key role in the generation and maintenance of cancer. Some of the metabolic…”
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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms by Kaeberlein, M, McVey, M, Guarente, L

“…The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in…”
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Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections by Ciccacci, F., De Santo, C., Mosconi, C., Orlando, S., Carestia, M., Guarente, L., Liotta, G., Palombi, L., Emberti Gialloreti, L.

“…Healthcare-associated infections (HAIs) burden healthcare globally. Amid the SARS-CoV-2 pandemic, intensified infection control measures, such as mask usage…”
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A therapeutic role for sirtuins in diseases of aging? by Westphal, C.H., Dipp, M.A., Guarente, L.

“…The sirtuins are a group of proteins linked to aging, metabolism and stress tolerance in several organisms. Among the many genes that have been shown to affect…”
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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans by Guarente, Leonard, Tissenbaum, Heidi A

“…In Caenorhabditis elegans, mutations that reduce the activity of an insulin-like receptor (daf-2) or a phosphatidylinositol-3-OH kinase (age-1) favour entry…”
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Molecular links between aging and adipose tissue by Picard, F, Guarente, L

“…White adipose tissue now emerges as a pivotal organ controlling lifespan. Calorie restriction, which so far extends lifespan in all organisms, primarily…”
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Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces Cerevisiae by Lin, Su-Ju, Defossez, Pierre-Antoine, Guarente, Leonard

“…Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may work by reducing the levels…”
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Diverse and dynamic functions of the Sir silencing complex by Guarente, L

“…The yeast Sir protein complex has been implicated in transcriptional silencing and suppression of recombination. The Sir complex creates structured chromosomal…”
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Heme binds to a short sequence that serves a regulatory function in diverse proteins by Zhang, L., Guarente, L.

“…Heme is a prosthetic group for numerous enzymes, cytochromes and globins, and it binds tightly, sometimes covalently, to these proteins. Interestingly, heme…”
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Calorie restriction and sirtuins revisited by Guarente, Leonard

“…Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient…”
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Sirtuins as potential targets for metabolic syndrome by Guarente, L

“…Metabolic syndrome threatens health gains made during the past century. Physiological processes degraded by this syndrome are often oppositely affected by…”
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Sirtuins and β-cell function by Bordone, L, Guarente, L

“…Over the past century, there have been major advances in medicine, diet and living conditions that have substantially extended the health span of people in the…”
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Sirtuins, aging, and metabolism by Guarente, Leonard

“…Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging…”
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Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer by Forsburg, S L, Guarente, L

“…The CYC1 gene of Saccharomyces cerevisiae is positively regulated by the HAP2 and HAP3 proteins, which form a heteromeric complex that binds to a CCAAT box in…”
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The Short Life Span of Saccharomyces cerevisiae sgs1 and srs2 Mutants Is a Composite of Normal Aging Processes and Mitotic Arrest Due to Defective Recombination by McVey, Mitch, Kaeberlein, Matt, Tissenbaum, Heidi A, Guarente, Leonard

“…Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which…”
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Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4 by Knaus, R, Pollock, R, Guarente, L

“…Activation of transcription in eukaryotes depends upon the interplay between transcriptional activators and general transcription factors. While direct…”
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Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding by McNabb, D S, Xing, Y, Guarente, L

“…The CCAAT-binding factor is a conserved heteromeric transcription factor that binds to CCAAT box-containing upstream activation sites (UASs) within the…”
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Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors by Marcus, G.A, Silverman, N, Berger, S.L, Horiuchi, J, Guarente, L

“…A selection for yeast mutants resistant to GAL4 - VP16-induced toxicity previously identified two genes, ADA2 and ADA3, which may function as adaptors for some…”
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SIRT1 in neurodevelopment and brain senescence by Herskovits, A Zara, Guarente, Leonard

“…Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals…”
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